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Anti-DNase B is a blood test to look for antibodies to a substance (protein) produced by group A streptococcus. This is the bacteria that cause strep throat.
When used together with the ASO titer test, more than 90% of past streptococcal infections can be correctly identified.
Strep throat - anti-DNase B test; Antideoxyribonuclease B titer; ADN-B test
No special preparation is necessary.
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
This test is most often done to tell if you have previously had a strep infection and if you might have rheumatic fever or kidney problems (glomerulonephritis) due to that infection.
A negative test is normal. Some people have low concentrations of antibodies, but they have not had a recent strep infection. Therefore, normal values in different age groups are:
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different specimens. Talk to your health care provider about the meaning of your specific test results.
Increased levels of DNase B levels indicate exposure to group A streptococcus.
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks:
Bryant AE, Stevens DL. Streptococcus pyogenes. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 197.
Chernecky CC, Berger BJ. Antideoxyribonuclease B antibody titer (anti-DNase B antibody, streptodornase) – serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. Philadelphia, St Louis, MO: Elsevier Saunders; 2013:145.
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