Dr. Cogle's research focus is on human hematopoietic stem cells and cancer initiating cells. Specifically, his laboratory is focused on the following projects:
- Defining the Hemangioblast Activity of the Human Hematopoietic Stem Cell (HSC)
- This project aims to define the ability of the human hematopoietic stem cell in repairing injured blood vessels. To test this hypothesis we track blood vessel repair in immunocompromised mice transplanted with human HSC enriched from umbilical cord blood, bone marrow and mobilized peripheral blood. Additionally, we study new blood vessel growth in patients and try to determine to what extent the bone marrow is the origin.
- Defining the Pathologic Hemangioblast Activity of the Hematopoietic Stem Cell in Cancer Blood Vessel Development
- This project seeks to define the ability of the hematopoietic stem cell and bone marrow in contributing to the pathologic growth of blood vessels within cancer. To test this hypothesis we analyze blood vessels growing within cancers asking to what extent they are of bone marrow origin. We have developed anti-cancer treatments based on this research.
- Bone Marrow Cell Injections for Heart Disease
- This project tests the ability of bone marrow cells to repair hearts after heart attacks. The Cogle laboratory is a core laboratory for the NIH Cardiovascular Cell Therapy Research Network, testing the functional capacity of bone marrow and blood in patients who receive bone marrow injections in their hearts. In addition, new technologies are being developed to enhance the function of bone marrow cells to repair the injured hearts better.
- Defining the Hemangioblast Activity of Leukemia Stem Cells
- This project aims to define how leukemias exhibit hemangioblast activity, producing not only malignant leukemic cells but also malignant endothelial cells. The significance of this project is that if leukemia demonstrates hemangioblast activity, the generated malignant endothelia may serve as a sanctuary for later relapse. This begs for an alternative approach to leukemia treatment.