Eric Sobel, M.D.

Eric S Sobel, M.D., Ph.D.

(352) 265-4846

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Publications

The utility of trough mycophenolic acid levels for the management of lupus nephritis
Nephrology Dialysis Transplantation
2019

A case of isolated renal involvement of polyarteritis nodosa successfully treated with steroid monotherapy
BMJ Case Reports
2016

A Novel Mechanism for Generating the Interferon Signature in Lupus Opsonization of Dead Cells By Complement and Igm
Arthritis & Rheumatology
2016

The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes Cd4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus.
Arthritis & Rheumatology
2014

Reduced Levels of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients Under Treatment With Prednisone, Mycophenolate Mofetil, Or Hydroxychloroquine, Except in a High Stat1 Subset
Arthritis Research & Therapy
2014

Positive Correlation of Stat1 and Mir-146a With Anemia in Patients With Systemic Lupus Erythematosus
Journal of Clinical Immunology
2014

Osteoarthritis and Psoriatic Arthritis: Findings in Three-Dimensional Biophotonics Imaging
Bio-Medical Materials and Engineering
2014

Increased Ifn-Alpha-Producing Plasmacytoid Dendritic Cells (Pdcs) in Human Th1-Mediated Type 1 Diabetes: Pdcs Augment Th1 Responses Through Ifn-Alpha Production
Journal of Immunology
2014

Elevated Signal Transducers and Activators of Transcription 1 Correlates With Increased C-C Motif Chemokine Ligand 2 and C-X-C Motif Chemokine 10 Levels in Peripheral Blood of Patients With Systemic Lupus Erythematosus
Arthritis Research & Therapy
2014

Noninvasive Imaging of Hemoglobin Concentration and Oxygen Saturation for Detection of Osteoarthritis in the Finger Joints Using Multispectral Three-Dimensional Quantitative Photoacoustic Tomography
Journal of Optics
2013

Maintenance of Anti-Sm/Rnp Autoantibody Production By Plasma Cells Residing in Ectopic Lymphoid Tissue and Bone Marrow Memory B Cells
Journal of Immunology
2013

Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology
2013

Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism
2013

Pre-B Cell Leukemia Homeobox 1 Is Associated With Lupus Susceptibility in Mice and Humans
Journal of Immunology
2012

Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Arthritis and Rheumatism
2012

Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Coexistence of Anti-Rna Polymerase Iii and Anti-U1Rnp Antibodies in Patients With Systemic Lupus Erythematosus: Two Cases Without Features of Scleroderma
Lupus
2012

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?
Arthritis and Rheumatism
2012

Autoantibodies To Transcription Intermediary Factor (Tif)1 Beta Associated With Dermatomyositis
Arthritis Research & Therapy
2012

Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism
2012

A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
Arthritis and Rheumatism
2012

Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis and Rheumatism
2011

Pathogenic Role of B Cells in the Development of Diffuse Alveolar Hemorrhage Induced By Pristane
Modern Pathology
2011

Il-1 Alpha Modulates Neutrophil Recruitment in Chronic Inflammation Induced By Hydrocarbon Oil
Journal of Immunology
2011

Gender and Ethnicity Differences in the Prevalence of Scleroderma-Related Autoantibodies
Clinical Rheumatology
2011

Frequent Coexistence of Anti-Topoisomerase I and Anti-U1Rnp Autoantibodies in African American Patients Associated With Mild Skin Involvement: a Retrospective Clinical Study
Arthritis Research & Therapy
2011

First Assessment of Three-Dimensional Quantitative Photoacoustic Tomography for in Vivo Detection of Osteoarthritis in the Finger Joints

2011

Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism
2011

Defective Response of Cd4(+) T Cells To Retinoic Acid and Tgf Beta in Systemic Lupus Erythematosus
Arthritis Research & Therapy
2011

Computer-Aided Classification of Optical Images for Diagnosis of Osteoarthritis in the Finger Joints
Journal of X-Ray Science and Technology
2011

Autoantibodies To Survival of Motor Neuron Complex in Patients With Polymyositis: Immunoprecipitation of D, E, F, and G Proteins Without Other Components of Small Nuclear Ribonucleoproteins
Arthritis and Rheumatism
2011

Atypical Clinical Presentation of a Subset of Patients With Anti-Rna Polymerase III - Non-Scleroderma Cases Associated With Dominant Rna Polymerase I Reactivity and Nucleolar Staining
Arthritis Research & Therapy
2011

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism
2011

Quantitative Two-Dimensional Photoacoustic Tomography of Osteoarthritis in the Finger Joints
Optics Express
2010

Murine Lupus Susceptibility Locus Sle1a Requires the Expression of Two Sub-Loci To Induce Inflammatory T Cells
Genes and Immunity
2010

Monocyte Surface Expression of Fc Gamma Receptor Ri (Cd64), a Biomarker Reflecting Type-I Interferon Levels in Systemic Lupus Erythematosus
Arthritis Research & Therapy
2010

High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: morphological and functional assessments.

2010

Endogenous Type-I Interferon Activity Is Not Associated With Depression Or Fatigue in Systemic Lupus Erythematosus
Journal of Neuroimmunology
2010

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation
American Journal of Pathology
2009

Quantitative Three-Dimensional Photoacoustic Tomography of the Finger Joints: An in Vivo Study
Journal of Biomedical Optics
2009

Increased Expression of Fc Gamma Ri/Cd64 On Circulating Monocytes Parallels Ongoing Inflammation and Nephritis in Lupus
Arthritis Research & Therapy
2009

Defective Retinoic Acid Expansion of Foxp3+Regulatory T Cells in Lupus

2009

Comparison of Diffusion Approximation and Higher Order Diffusion Equations for Optical Tomography of Osteoarthritis
Journal of Biomedical Optics
2009

Citrulline Dependence of Anti-Cyclic Citrullinated Peptide Antibodies in Systemic Lupus Erythematosus as a Marker of Deforming/Erosive Arthritis

2009

Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients

2009

Tomographic X-Ray-Guided Three-Dimensional Diffuse Optical Tomography of Osteoarthritis in the Finger Joints
Journal of Biomedical Optics
2008

Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism
2008

Patients With Pulmonary Tuberculosis Are Frequently Positive for Anti-Cyclic Citrullinated Peptide Antibodies, But Their Sera Also React With Unmodified Arginine-Containing Peptide
Arthritis and Rheumatism
2008

Intrafollicular Location of Marginal Zone/Cd1D(Hi) B Cells Is Associated With Autoimmune Pathology in a Mouse Model of Lupus
Modern Pathology
2008

High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism
2008

Defective B-Cell Response To T-Dependent Immunization in Lupus-Prone Mice
European Journal of Immunology
2008

Comparison of Chlordecone and Estradiol Effects On Splenic T-Cells in (Nzb X Nzw)F-1 Mice
Toxicology letters
2008

Colocalization of Antigen-Specific B and T Cells Within Ectopic Lymphoid Tissue Following Immunization With Exogenous Antigen
Journal of Immunology
2008

Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism
2008

Deficiency of the type I interferon receptor protects mice from experimental lupus
Arthritis and Rheumatism
2007

Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert Review of Clinical Immunology
2007

Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)
American Journal of Pathology
2006

Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p
Arthritis and Rheumatism
2006

Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice.
Toxicology
2006

Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus
Clinical Immunology
2005

Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice.
Environmental Health Perspectives
2005

Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.
Journal of Immunology
2002

Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells.
Journal of Immunology
1999

Research Interests

Our laboratory is interested in murine models of autoimmune disease, both spontaneous and induced. We have two major projects. The first uses mercury chloride to induce an anti-nucleolar response in certain strains of mice. This response is directed to fibrillarin, a ribosomal RNA processing protein and is a specificity most commonly found in systemic sclerosis (scleroderma). We are examining the cellular interactions leading to this response.

In the second major project, we are collaborating with Dr. Edward Wakeland and Dr. Laurence Morel in the complex genetic inheritance of lupus in the NZM/2410 mice, which were derived from the classic (NZBxNZW)F1 model. Genetic intervals have been identified and individually backcrossed onto non-autoimmune strains of mice. Through bone marrow transplant experiments, we are exploring how these genes are expressed and delineating the immunological pathways they affect. The overall goal is to identify genes leading to a break in tolerance to self-antigen.