Frederick Southwick, M.D.

Frederick S Southwick, M.D.

(352) 594-2866

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Publications

Neuraxial and peripheral misconnection events leading to wrong-route medication errors: a comprehensive literature review.
Regional anesthesia and pain medicine
2021

Increasing adherence to a standardized rounding procedure in two hospital in-patient units.
Journal of applied behavior analysis
2021

In response: neuraxial and peripheral misconnection events leading to wrong-route medication errors.
Regional anesthesia and pain medicine
2021

Improving the Definition of Coronavirus Disease 2019-Related Deaths.
The Journal of infectious diseases
2021

The Loss of Social Connectedness as a Major Contributor to Physician Burnout: Applying Organizational and Teamwork Principles for Prevention and Recovery.
JAMA psychiatry
2020

No human exists in isolation or as an island: The outcomes of a multidisciplinary, global, and context-specific COVID-19 consortium.
American journal of disaster medicine
2020

Infectious diseases occurring in the context of substance use disorders: A concise review.
Journal of the Neurological Sciences
2020

Health Care Provider Factors Associated with Patient-Reported Adverse Events and Harm.
Joint Commission journal on quality and patient safety
2020

Teaching novice clinicians how to reduce diagnostic waste and errors by applying the Toyota Production System.
Diagnosis (Berlin, Germany)
2019

The Loss of a Sense of Control as a Major Contributor to Physician Burnout: A Neuropsychiatric Pathway to Prevention and Recovery.
JAMA psychiatry
2018

Learning From Patients' Experiences Related To Diagnostic Errors Is Essential For Progress In Patient Safety.
Health affairs (Project Hope)
2018

The lazy leukocyte syndrome revisited.
Blood
2016

A patient-initiated voluntary online survey of adverse medical events: the perspective of 696 injured patients and families.
BMJ quality & safety
2015

Exserohilum rostratum: characterization of a cross-kingdom pathogen of plants and humans.
PloS one
2014

Applying athletic principles to medical rounds to improve teaching and patient care.
Academic medicine : journal of the Association of American Medical Colleges
2014

Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
Cellular microbiology
2013

Perspective: a business school view of medical interprofessional rounds: transforming rounding groups into rounding teams.
Academic medicine : journal of the Association of American Medical Colleges
2012

Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.
BMC immunology
2012

Anthrax lethal and edema toxins fail to directly impair human platelet function.
The Journal of infectious diseases
2012

All'S Not Fair in Science and Publishing
Scientist
2012

The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one
2011

Commentary: IDSA guidelines for improving the teaching of preclinical medical microbiology and infectious diseases.
Academic medicine : journal of the Association of American Medical Colleges
2010

Brucella, voles, and emerging pathogens.
The Journal of infectious diseases
2010

Commentary: "Who was caring for Mary?" revisited: a call for all academic physicians caring for patients to focus on systems and quality improvement.
Academic medicine : journal of the Association of American Medical Colleges
2009

Bacillus anthracis edema toxin impairs neutrophil actin-based motility.
Infection and immunity
2009

Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field.
Infection control and hospital epidemiology
2008

Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook.
Transactions of the American Clinical and Climatological Association
2007

Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.
The EMBO journal
2007

A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
The EMBO journal
2006

Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation.
The Journal of biological chemistry
2005

Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.
Proceedings of the National Academy of Sciences of the United States of America
2005

Anthrax lethal toxin paralyzes neutrophil actin-based motility.
The Journal of infectious diseases
2005

Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
The Journal of biological chemistry
2003

CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity
2003

Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
Cell motility and the cytoskeleton
2003

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Molecular medicine (Cambridge, Mass.)
2002

Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America
2002

Actin-based phagosome motility.
Cell motility and the cytoskeleton
2002

A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
Archives of biochemistry and biophysics
2002

Who was caring for Mary? 1993.
Obstetrics and gynecology
2001

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Nature cell biology
2001

Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.
The Journal of cell biology
2001

Shigella actin-based motility in the presence of truncated vinculin.
Cell motility and the cytoskeleton
2000

Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
Proceedings of the National Academy of Sciences of the United States of America
2000

Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
The Journal of biological chemistry
1999

Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
Methods in enzymology
1999

Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular cell biology research communications : MCBRC
1999

Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular Cell Biology Research Communications
1999

Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.
Proceedings of the National Academy of Sciences of the United States of America
1998

Listeria and Shigella actin-based motility in host cells.
Transactions of the American Clinical and Climatological Association
1998

Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells.
Infection and immunity
1998

Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.
The Journal of cell biology
1997

Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility.
Biochemistry
1997

ABM-1 and ABM-2 homology sequences: consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP.
Biochemical and biophysical research communications
1997

Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.
The Journal of cell biology
1996

Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.
Biochemistry
1996

Intracellular pathogenesis of listeriosis.
The New England journal of medicine
1996

Septic thrombophlebitis of major dural venous sinuses.
Current clinical topics in infectious diseases
1995

Listeria monocytogenes intracellular migration: inhibition by profilin, vitamin D-binding protein and DNase I.
Cell motility and the cytoskeleton
1995

Inhibition of Listeria locomotion by mosquito oostatic factor, a natural oligoproline peptide uncoupler of profilin action.
Infection and immunity
1995

Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
The Journal of biological chemistry
1995

The human actin-regulatory protein cap G: gene structure and chromosome location.
Genomics
1994

Dynamic remodeling of the actin cytoskeleton: lessons learned from Listeria locomotion.
BioEssays : news and reviews in molecular, cellular and developmental biology
1994

Calcium regulation of actin filament capping and monomer binding by macrophage capping protein.
The Journal of biological chemistry
1994

Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
Proceedings of the National Academy of Sciences of the United States of America
1994

Who was caring for Mary?
Annals of internal medicine
1993

Diminished actin polymerization by neutrophils from newborn infants.
Pediatric research
1993

Acute bacterial meningitis in adults. A review of 493 episodes.
The New England journal of medicine
1993

Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
The Journal of biological chemistry
1992

Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
Infection and immunity
1992

Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4-phosphate kinase by concanavalin A and formyl-methionyl-leucyl-phenylalanine is calcium-independent. Correlation with maintenance of actin assembly.
Journal of immunology (Baltimore, Md. : 1950)
1991

Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway.
Journal of immunology (Baltimore, Md. : 1950)
1991

The actin released from profilin--actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.
The Journal of cell biology
1990

Septic cortical thrombophlebitis.
The Journal of infectious diseases
1990

Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
Proceedings of the National Academy of Sciences of the United States of America
1990

Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period.
Biochemistry
1990

The relationship between CR3 deficiency and neutrophil actin assembly.
Blood
1989

Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
The Journal of cell biology
1989

Recurrent cystitis and bladder mass in two adults with chronic granulomatous disease.
Annals of internal medicine
1988

Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members.
The Journal of clinical investigation
1988

Contractile proteins in leukocytes.
Methods in enzymology
1988

Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly.
Blood
1987

Septic thrombosis of the dural venous sinuses.
Medicine
1986

Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the "barbed" ends of actin filaments but does not sever them.
The Journal of biological chemistry
1986

Nonmuscle actin-binding proteins.
Annual review of cell biology
1985

Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin.
The Journal of biological chemistry
1985

The motor of leukocytes.
Federation proceedings
1984

Sphenoid sinusitis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
1984

An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells.
The Journal of cell biology
1984

Sphenoid sinusitis. A review of 30 cases.
The New England journal of medicine
1983

Contractile proteins in leukocyte function.
Seminars in hematology
1983

Acumentin, an actin-modulating protein of rabbit pulmonary macrophages.
Biochemistry
1982

Acumentin, a protein in macrophages which caps the "pointed" end of action filaments.
Nature
1982

Isolation of an inhibitor of actin polymerization from human polymorphonuclear leukocytes.
The Journal of biological chemistry
1981

A variant of chronic granulomatous disease: deficient oxidative metabolism due to a low-affinity NADPH oxidase.
The New England journal of medicine
1981

Hemophilus influenzae in hospitalized adults: current perspectives.
The American journal of medicine
1980

An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
The New England journal of medicine
1980

Defective leukocyte metabolism.
The New England journal of medicine
1979

Multifactorial index of cardiac risk in noncardiac surgical procedures.
The New England journal of medicine
1977