Guangbin Xia, M.D.

Guangbin Xia, M.D., Ph.D.

(352) 273-5550

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Publications

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2021

The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3.
Parkinsonism & related disorders
2020

Dysphagia in spinocerebellar ataxias type 1, 2, 3 and 6.
Journal of the neurological sciences
2020

A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1.
Frontiers in genetics
2020

Tremor in the Degenerative Cerebellum: Towards the Understanding of Brain Circuitry for Tremor.
Cerebellum (London, England)
2019

Abnormal nuclear aggregation and myotube degeneration in myotonic dystrophy type 1.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2019

Therapeutic Genome Editing for Myotonic Dystrophy Type 1 Using CRISPR/Cas9.
Molecular therapy : the journal of the American Society of Gene Therapy
2018

Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies.
Current stem cell reports
2018

Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple Mechanisms.
ACS chemical biology
2018

Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients.
The American journal of pathology
2018

C9orf72 repeat expansions as genetic modifiers for depression in spinocerebellar ataxias.
Movement disorders : official journal of the Movement Disorder Society
2018

The Initial Symptom and Motor Progression in Spinocerebellar Ataxias.
Cerebellum (London, England)
2017

RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.
Neuron
2017

Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias.
Tremor and other hyperkinetic movements (New York, N.Y.)
2017

In Situ Printing-then-Mixing for Biological Structure Fabrication Using Intersecting Jets.
ACS biomaterials science & engineering
2017

Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9.
Molecular cell
2017

Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.
Cell
2017

Dystonia and ataxia progression in spinocerebellar ataxias.
Parkinsonism & related disorders
2017

A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.
Human molecular genetics
2017

Genome Therapy of Myotonic Dystrophy Type 1 iPS Cells for Development of Autologous Stem Cell Therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
2016

Depression and clinical progression in spinocerebellar ataxias.
Parkinsonism & related disorders
2016

Ataxia.
Continuum (Minneapolis, Minn.)
2016

ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis.
Annals of neurology
2016

Vascular risk factors and clinical progression in spinocerebellar ataxias.
Tremor and other hyperkinetic movements (New York, N.Y.)
2015

Spinocerebellar ataxia type 10 in Chinese Han.
Neurology. Genetics
2015

Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.
Stem cells (Dayton, Ohio)
2015

Dynamic changes of nuclear RNA foci in proliferating DM1 cells.
Histochemistry and cell biology
2015

Coenzyme Q10 and spinocerebellar ataxias.
Movement disorders : official journal of the Movement Disorder Society
2015

Clinical evaluation of eye movements in spinocerebellar ataxias: a prospective multicenter study.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
2015

A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.
Human molecular genetics
2015

Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10.
Journal of neurology, neurosurgery, and psychiatry
2013

Generation of neural cells from DM1 induced pluripotent stem cells as cellular model for the study of central nervous system neuropathogenesis.
Cellular reprogramming
2013

Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro.
Journal of molecular neuroscience : MN
2013

Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; a prospective observational study.
Orphanet journal of rare diseases
2013

Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: a toxic RNA gain-of-function model.
Journal of neuroscience research
2012

Neuropathologic Findings in Myotonic Dystrophy Type 2
Journal of Neuropathology and Experimental Neurology
2012

Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy.
Neuron
2012

Clinical Characteristics of Spinocerebellar Ataxias 1, 2, 3 and 6

2012

Characterization of Sequence Interruptions in Attct Repeat Expansions in Sca10

2012

Receptor tyrosine kinase EphB4 is a survival factor in breast cancer.
The American journal of pathology
2006

Up-regulation of EphB4 in mesothelioma and its biological significance.
Clinical cancer research : an official journal of the American Association for Cancer Research
2005

Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium.
Blood
2005