Heart failure: Research Studies

16 Related Result(s)

  1. Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

    This randomized phase IIb trial studies how well low-dose carvedilol works in preventing heart failure in cancer survivors exposed to high dose...

  2. CardiAMP™ Heart Failure Trial

    The purpose of this study is to examine if an investigational procedure can correct the parts of the heart muscle that are not working properly due to a...

  3. A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (VICTORIA)

    The purpose of this research study is to determine the safety and effectiveness of an experimental study drug (MK-1242) for the treatment of heart failure. ...

  4. Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure (PREVENT-HF): A Phase 2b Randomized Placebo-Controlled (Carvedilol) Trial

    To determine the impact of a two-year course of low-dose carvedilol on surrogate echocardiographic indices of heart failure (HF) risk, including:1. Left...

  5. Cardiac Stem Cells as Regenerative Therapy for Heart Failure (CONCERT)

    The purpose of this study is to determine whether giving MSCs (mesenchymal stem cells) and/or CSCs (C-kit+ Cardiac stem cells) to patients with heart muscle...

  6. Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

    The purpose of this study is to look at the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer...

  7. Phase 1/2 Study of Liposomal Annamycin for the Treatment of Subjects with Acute Myeloid Leukemia (AML) that is Refractory to or Relapsed after Standard Induction Therapy

    This is a multi-center, open-label, dose escalation study that will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of...

  8. A Clinical Study to Demonstrate Safety and Efficacy of E7777 (Denileukin Diftitox) in Persistent or Recurrent Cutaneous T-Cell Lymphoma

    The purpose of this trial is to assess the efficacy and safety of E7777 (improved purity ONTAK [denileukin diftitox]) in patients with persistent and...

  9. Phase 1a/1b Dose Escalation and Expansion Study of SBP-101 in Combination with Nab-Paclitaxel and Gemcitabine in Subjects with Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma

    The primary objective of the Phase 1a dose-escalation study is to determine the RD and DLTs of SBP-101 when administered in combination with standard dose...

  10. A Phase 3 Randomized, Open-Label Study Comparing Pexa-Vec (Vaccinia GM-CSF/Thymidine Kinase-Deactivated Virus) Followed by Sorafenib Versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma (HCC) Without Prior Systemic Therapy

    The primary objective is to determine and compare the overall survival of patients with advanced Hepatocellular Carcinoma or liver cancer, without prior...

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