James Wynn, M.D.

James L Wynn, M.D.

(352) 392-4195

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Publications

Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis
Shock
2020

Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis
Plos One
2020

Rethinking management of neonates at risk of sepsis
Lancet
2019

Prolonged early antimicrobials in ELBWs: too much for too little
Pediatric Research
2019

Early onset and hospital acquired neonatal sepsis associated with high mortality
Journal of Pediatrics
2019

A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants
Pediatric Research
2019

Validation of the Sepsis Metascore for Diagnosis of Neonatal Sepsis

2018

Progress in the management of neonatal sepsis: the importance of a consensus definition
Pediatric Research
2018

Name and Characteristics of National Institutes of Health R01-Funded Pediatric Physician-Scientists: Hope and Challenges for the Vanishing Pediatric Physician-Scientists
Jama Pediatrics
2018

Limited achievement of NIH research independence by pediatric K award recipients.
Pediatric Research
2018

Impact of Toll-Like Receptor 4 Stimulation on Human Neonatal Neutrophil Spontaneous Migration, Transcriptomics, and Cytokine Production

2018

Enteral Feeding As An Adjunct to Hypothermia in Neonates With Hypoxic-Ischemic Encephalopathy

2018

Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality.
Journal of immunology (Baltimore, Md. : 1950)
2018

Complete Genome Sequence of the Multidrug-Resistant Neonatal Meningitis Escherichia coli Serotype O75:H5:K1 Strain mcjchv-1 (NMEC-O75)
Microbiology resource announcements
2018

Chorioamnionitis, Il-17a, and Fetal Origins of Neurologic Disease
American Journal of Reproductive Immunology and Microbiology
2018

Unique Transcriptomic Response to Sepsis Is Observed Among Patients of Different Age Groups
PLOS One
2017

Timing of Multiorgan Dysfunction Among Hospitalized Infants With Fatal Fulminant Sepsis

2017

Survival, Bacterial Clearance and Thrombocytopenia Are Improved in Polymicrobial Sepsis By Targeting Nuclear Transport Shuttles
PLOS One
2017

Neutrophil Chemotaxis and Transcriptomics in Term and Preterm Neonates
Translational Research
2017

Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches
Frontiers in Pediatrics
2017

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model
Molecular Medicine
2016

Heart Rate Characteristic Index Monitoring for Bloodstream Infection in An Nicu: a 3-Year Experience

2016

Defining neonatal sepsis
Current Opinion in Pediatrics
2016

Trif-Dependent Innate Immune Activation Is Critical for Survival To Neonatal Gram-Negative Sepsis
Journal of Immunology
2015

Neonatal Cd71(+) Erythroid Cells Do Not Modify Murine Sepsis Mortality
Journal of Immunology
2015

Il-18 Increases Murine Neonatal Sepsis Mortality Via Il-17a
Shock
2015

Role of Innate Immunity in Neonatal Infection

2013

Loss of Myd88 Or Trif Does Not Impact Survival To Neonatal Polymicrobial Sepsis
Shock
2012

Critical Role for Cxc Ligand 10/Cxc Receptor 3 Signaling in the Murine Neonatal Response To Sepsis
Infection and Immunity
2011

B Cells Enhance Early Innate Immune Responses During Bacterial Sepsis
Journal of Experimental Medicine
2011

Type I Interferon Signaling in Hematopoietic Cells Is Required for Survival in Mouse Polymicrobial Sepsis By Regulating Cxcl10
Journal of Experimental Medicine
2010

The Role of Ip-10/Cxcr3 in the Neonatal Immune Response To a Septic Insult
Shock
2010

Probiotic Microbes: Do They Need To Be Alive To Be Beneficial?
Nutrition reviews
2009

Potential of Immunomodulatory Agents for Prevention and Treatment of Neonatal Sepsis
Journal of Perinatology
2009

Blockade of Ip-10 Inhibits Adjuvant-Induced Protection During Neonatal Sepsis
Shock
2009

Stromal Cell Derived Factor-1 Mediates Myeloid Derived Suppressor Cell Expansion During Polymicrobial Sepsis
Shock
2008

Polymicrobial Sepsis Activates B Cells Through a Type I Interferon Dependent But Myd88 Independent Pathway
Shock
2008

Defective Neonatal Innate Immunity Causes Poor Sepsis Outcome, But Is Overcome By Select Toll-Like Receptor Agonists
Shock
2008

Defective Innate Immunity Predisposes Murine Neonates To Poor Sepsis Outcome But Is Reversed By Tlr Agonists
Blood
2008

Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis
Shock
2007

Research Interests

The Wynn laboratory (http://wynn.research.pediatrics.med.ufl.edu) is focused on the investigation of neonatal-specific innate immune cellular function and inflammatory signaling during sepsis as well as development of novel therapeutic immunomodulatory strategies aimed at improving sepsis outcomes. Sepsis represents a significant clinical problem in the developmentally immature preterm neonate where attack rates may reach 60 percent with a 40 percent rate of death/major disability in developed countries. We employ both preclinical mechanistic investigations in association with observational human studies to improve our understanding of the neonatal-specific host response to sepsis. We use a wide variety of molecular and genetic techniques to interrogate the immune response via in vivo, ex vivo, and in vitro approaches. Applications of our work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.