Josef Neu, M.D.

Josef Neu, M.D.

(352) 273-8985

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Publications

Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.
The Journal of pediatrics
2021

Perspectives of pregnant and breastfeeding women on longitudinal clinical studies that require non-invasive biospecimen collection - a qualitative study.
BMC pregnancy and childbirth
2021

Duration of neonatal intensive care unit exposure associated with decreased risk of atopic dermatitis.
Pediatric dermatology
2021

Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.
Scientific reports
2021

Using machine learning analysis to assist in differentiating between necrotizing enterocolitis and spontaneous intestinal perforation: A novel predictive analytic tool.
Journal of pediatric surgery
2020

Preterm neonatal immunology at the intestinal interface.
Cellular and molecular life sciences : CMLS
2020

Postnatal pediatric systemic antibiotic episodes during the first three years of life are not associated with mode of delivery.
PloS one
2020

Necrotizing Enterocolitis: The Future.
Neonatology
2020

Necrotizing Enterocolitis: A Multi-omic Approach and the Role of the Microbiome.
Digestive diseases and sciences
2020

Metabolomic Profile of Personalized Donor Human Milk.
Molecules (Basel, Switzerland)
2020

Implications of the vaginal microbiome and potential restorative strategies on maternal health: a narrative review.
Journal of perinatal medicine
2020

Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.
BMC microbiology
2020

Gut Microbiota, Host Gene Expression, and Cell Traffic via Milk.
Nestle Nutrition Institute workshop series
2020

Gut Injury and the Microbiome in Neonates.
Clinics in perinatology
2020

Effect of Aspiration and Evaluation of Gastric Residuals on Intestinal Inflammation, Bleeding, and Gastrointestinal Peptide Level.
The Journal of pediatrics
2020

Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes.
JAMA network open
2020

Antibiotics Effects on the Fecal Metabolome in Preterm Infants.
Metabolites
2020

An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants.
Neonatology
2020

A Qualitative Study of Pregnant Women's Perspectives on Antibiotic Use for Mom and Child: Implications for Developing Tailored Health Education Interventions.
Antibiotics (Basel, Switzerland)
2020

The infantile cutaneous microbiome: A review.
Pediatric dermatology
2019

Pathophysiology of Necrotizing Enterocolitis: An Update.
Current pediatric reviews
2019

Necrotizing Enterocolitis: Long Term Complications.
Current pediatric reviews
2019

Multiomics-based strategies for taming intestinal inflammation in the neonate.
Current opinion in clinical nutrition and metabolic care
2019

Mother's Own Milk: How Does It Differ from Donor Milk for the Baby.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
2019

Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Scientific reports
2019

Initial microbial community of the neonatal stomach immediately after birth.
Gut microbes
2019

Fueling the Optimal Microbiome: Interventions for Severe Acute Malnutrition.
Cell host & microbe
2019

Effect of Gastric Residual Evaluation on Enteral Intake in Extremely Preterm Infants: A Randomized Clinical Trial.
JAMA pediatrics
2019

Consumption of Mother's Own Milk by Infants Born Extremely Preterm Following Implementation of a Donor Human Milk Program: A Retrospective Cohort Study.
The Journal of pediatrics
2019

The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes.
Neonatology
2018

Necrotizing enterocolitis: The intestinal microbiome, metabolome and inflammatory mediators.
Seminars in fetal & neonatal medicine
2018

Necrotizing enterocolitis comes in different forms: Historical perspectives and defining the disease.
Seminars in fetal & neonatal medicine
2018

Maternal milk feedings reduce sepsis, necrotizing enterocolitis and improve outcomes of premature infants.
Journal of perinatology : official journal of the California Perinatal Association
2018

Gastrointestinal Development: Implications for Management of Preterm and Term Infants.
Gastroenterology clinics of North America
2018

Food Protein-Induced Enterocolitis Instead of Necrotizing Enterocolitis? A Neonatal Intensive Care Unit Case Series.
The Journal of pediatrics
2018

Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy.
Neonatology
2018

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity.
Investigative ophthalmology & visual science
2018

Electrogastrography, Near-infrared Spectroscopy, and Acoustics to Measure Gastrointestinal Development in Preterm Babies.
Journal of pediatric gastroenterology and nutrition
2018

What Are Optimal Cesarean Section Rates in the U.S. and How Do We Get There? A Review of Evidence-Based Recommendations and Interventions.
Journal of women's health (2002)
2017

Probiotics in Newborns and Children.
Pediatric clinics of North America
2017

Potential Nutrients for Preventing or Treating Bronchopulmonary Dysplasia.
Paediatric respiratory reviews
2017

Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus.
Scientific reports
2017

Personalization of the Microbiota of Donor Human Milk with Mother's Own Milk.
Frontiers in microbiology
2017

Pathogenesis of NEC: Impact of an altered intestinal microbiome.
Seminars in perinatology
2017

Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants.
The American journal of clinical nutrition
2017

Necrotizing Enterocolitis and Human Milk Feeding: A Systematic Review.
Clinics in perinatology
2017

Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development.
Frontiers in pediatrics
2017

Dysbiosis in the Neonatal Period: Role of Cesarean Section.
Nestle Nutrition Institute workshop series
2017

Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation
The Journal Of Clinical Investigation
2017

Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project.
The American journal of clinical nutrition
2016

The microbiome during pregnancy and early postnatal life.
Seminars in fetal & neonatal medicine
2016

The human gut microbiota in perinatology and neonatology.
Seminars in fetal & neonatal medicine
2016

Intestinal Microbiota Studies in Preterm Infants.
Journal of pediatric gastroenterology and nutrition
2016

The value of routine evaluation of gastric residuals in very low birth weight infants.
Journal of perinatology : official journal of the California Perinatal Association
2015

Reply--Gastric residuals, feeding intolerance, and nectrotizing enterocolitis in preterm infants.
Pediatrics and neonatology
2015

Preterm infant nutrition, gut bacteria, and necrotizing enterocolitis.
Current opinion in clinical nutrition and metabolic care
2015

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants.
Pediatric research
2015

Early factors leading to later obesity: interactions of the microbiome, epigenome, and nutrition.
Current problems in pediatric and adolescent health care
2015

Developmental aspects of maternal-fetal, and infant gut microbiota and implications for long-term health.
Maternal health, neonatology and perinatology
2015

Aspiration and evaluation of gastric residuals in the neonatal intensive care unit: state of the science.
The Journal of perinatal & neonatal nursing
2015

The time for a confirmative necrotizing enterocolitis probiotics prevention trial in the extremely low birth weight infant in North America is now!
The Journal of pediatrics
2014

The developing intestinal microbiome: probiotics and prebiotics.
World review of nutrition and dietetics
2014

The Infant Intestinal Microbiome: Friend Or Foe (Vol 86, Pg S67, 2010)
Early Human Development
2014

Probiotics and necrotizing enterocolitis.
Clinics in perinatology
2014

Packed red blood cell transfusion is not associated with increased risk of necrotizing enterocolitis in premature infants.
Journal of perinatology : official journal of the California Perinatal Association
2014

Necrotizing enterocolitis: the mystery goes on.
Neonatology
2014

Necrotizing enterocolitis.
World review of nutrition and dietetics
2014

Meconium microbiome analysis identifies bacteria correlated with premature birth.
PloS one
2014

Manipulation of the intestinal microbiome in newborn infants.
Advances in nutrition (Bethesda, Md.)
2014

Gastric residual evaluation in preterm neonates: a useful monitoring technique or a hindrance?
Pediatrics and neonatology
2014

Decoding the enigma of necrotizing enterocolitis in premature infants.
Pathophysiology : the official journal of the International Society for Pathophysiology
2014

The altered gut microbiome and necrotizing enterocolitis.
Clinics in perinatology
2013

The Microbiome and Its Impact on Disease in the Preterm Patient.
Current pediatrics reports
2013

Pilot study using proteomics to identify predictive biomarkers of necrotizing enterocolitis from buccal swabs in very low birth weight infants.
Neonatology
2013

Nutrition support of neonatal patients at risk for necrotizing enterocolitis: response to Fallon et al (2012).
JPEN. Journal of parenteral and enteral nutrition
2013

Intestinal mucosal defense system, Part 2. Probiotics and prebiotics.
The Journal of pediatrics
2013

Intestinal mucosal defense system, Part 1. Consensus recommendations for immunonutrients.
The Journal of pediatrics
2013

Intestinal microbial ecology and environmental factors affecting necrotizing enterocolitis.
PloS one
2013

Glutamine supplementation in neonates: is there a future?
Nestle Nutrition Institute workshop series
2013

Gastrointestinal function development and microbiota.
Italian journal of pediatrics
2013

Feeding the preterm infant: opportunities and challenges of bringing science to the bedside.
The Journal of pediatrics
2013

Effect of intestinal microbial ecology on the developing brain.
JAMA pediatrics
2013

Distortions in development of intestinal microbiota associated with late onset sepsis in preterm infants.
PloS one
2013

A Pocock approach to sequential meta-analysis of clinical trials.
Research synthesis methods
2013

Systems Biology Approach in Pathway Analysis of Low Dose Flagellin Induced Tolerance To Flagellin-Stimulated Inflammation in Caco-2 Cells
The FASEB's Journal
2012

Recent developments in necrotizing enterocolitis.
JPEN. Journal of parenteral and enteral nutrition
2012

Microbial cell components induced tolerance to flagellin-stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells.
Cytokine
2012

Lactation and neonatal nutrition: defining and refining the critical questions.
Journal of mammary gland biology and neoplasia
2012

Gut microbiota correlates with energy gain from dietary fibre and appears to be associated with acute and chronic intestinal diseases.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2012

Buccal Swab Il-1Ra in Necrotizing Enterocolitis: a Predictive Biomarker
The FASEB's Journal
2012

Baby and breast: a dynamic interaction.
Pediatric research
2012

Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice.
Journal of pediatric gastroenterology and nutrition
2012

Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice.
Nutrition (Burbank, Los Angeles County, Calif.)
2012

Toward defining the autoimmune microbiome for type 1 diabetes.
The ISME journal
2011

The intestinal microbiome of infants and the use of probiotics.
Current opinion in pediatrics
2011

The developing intestinal microbiome and its relationship to health and disease in the neonate.
Journal of perinatology : official journal of the California Perinatal Association
2011

Routine probiotics for premature infants: let's be careful!
The Journal of pediatrics
2011

Probiotics for pregnant women and preterm neonates.
The American journal of clinical nutrition
2011

Necrotizing enterocolitis.
The New England journal of medicine
2011

NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants.
Pediatrics
2011

Medical Progress: Necrotizing Enterocolitis.
New England Journal of Medicine
2011

Long-term effects of neonatal glutamine-enriched nutrition in very-low-birth-weight infants.
Nutrition reviews
2011

Ischemia-reperfusion and neonatal intestinal injury.
The Journal of pediatrics
2011

Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.
Journal of immunology (Baltimore, Md. : 1950)
2011

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
PloS one
2011

Fecal microbiota in premature infants prior to necrotizing enterocolitis.
PloS one
2011

Early postnatal nutrition and programming of the preterm neonate.
Nutrition reviews
2011

Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis.
Clinics in perinatology
2011

The intestinal microbiome: relationship to type 1 diabetes.
Endocrinology and metabolism clinics of North America
2010

The infant intestinal microbiome: friend or foe?
Early human development
2010

Nonadministration of routine probiotics unethical--really?
Pediatrics
2010

NIH consensus development conference: Inhaled nitric oxide therapy for premature infants.
NIH consensus and state-of-the-science statements
2010

Monitoring technologies in the neonatal intensive care unit: implications for the detection of necrotizing enterocolitis.
Journal of perinatology : official journal of the California Perinatal Association
2010

Molecular modulation of intestinal epithelial barrier: contribution of microbiota.
Journal of biomedicine & biotechnology
2010

Maternal Separation in the Neonatal Period Decreases Adipose Gr and 11 Beta Hsd Mrna in the Adult Rat
Journal of Investigative Medicine
2010

Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one
2010

Intestinal microbial ecology in premature infants assessed with non-culture-based techniques.
The Journal of pediatrics
2010

Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee On Nutrition
Journal of Pediatric Gastroenterology and Nutrition
2010

Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition
2010

Use of nutrition to prevent stress-induced immunosuppression in the pediatric intensive care unit: a clinical trials minefield.
JPEN. Journal of parenteral and enteral nutrition
2009

Resident duty hour restrictions: is less really more?
The Journal of pediatrics
2009

Probiotics and prevention of necrotizing enterocolitis.
Early human development
2009

Probiotic microbes: do they need to be alive to be beneficial?
Nutrition reviews
2009

Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008.
The Journal of pediatrics
2009

Potential of Immunomodulatory Agents for Prevention and Treatment of Neonatal Sepsis
Journal of Perinatology
2009

Metabolic effects of different protein intakes after short term undernutrition in artificially reared infant rats.
Early human development
2009

Live and heat-killed Lactobacillus rhamnosus GG: effects on proinflammatory and anti-inflammatory cytokines/chemokines in gastrostomy-fed infant rats.
Pediatric research
2009

Is It Time To Stop Starving Premature Infants?
Journal of Perinatology
2009

Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal
2009

Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells.
The Journal of nutrition
2009

Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal
2009

Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention?
Pediatric research
2009

50 Years Ago in the Journal of Pediatrics Lactic Acid Milk in the Feeding of Premature Infants
Journal of Pediatrics
2009

The Intestinal Microbiome: Friend Or Foe?
Neonatology
2008

The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.
Diabetes
2008

Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research
2008

Live and ultraviolet-inactivated Lactobacillus rhamnosus GG decrease flagellin-induced interleukin-8 production in Caco-2 cells.
The Journal of nutrition
2008

Intestinal microbiota development in the premature neonate: establishment of a lasting commensal relationship?
Nutrition reviews
2008

A roadmap for understanding and preventing necrotizing enterocolitis.
Current gastroenterology reports
2008

Postnatal nutrition and adult health programming.
Seminars in fetal & neonatal medicine
2007

Perinatal and neonatal manipulation of the intestinal microbiome: a note of caution.
Nutrition reviews
2007

Pathophysiology of glutamine and glutamate metabolism in premature infants.
Current opinion in clinical nutrition and metabolic care
2007

Microbes and the developing gastrointestinal tract.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2007

Gastrointestinal maturation and implications for infant feeding.
Early human development
2007

Gastrointestinal development and meeting the nutritional needs of premature infants.
The American journal of clinical nutrition
2007

Arginine supplementation for neonatal necrotizing enterocolitis: are we ready?
The British journal of nutrition
2007

The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy.
Investigative ophthalmology & visual science
2006

NICHD: AAP workshop on neonatology research and training areas of research in neonatal gastroenterology.
Journal of perinatology : official journal of the California Perinatal Association
2006

Lactobacillus rhamnosus GG decreases lipopolysaccharide-induced systemic inflammation in a gastrostomy-fed infant rat model.
Journal of pediatric gastroenterology and nutrition
2006

Gastrointestinal maturation and feeding.
Seminars in perinatology
2006

The developing intestinal ecosystem: implications for the neonate.
Pediatric research
2005

The 'myth' of asphyxia and hypoxia-ischemia as primary causes of necrotizing enterocolitis.
Biology of the neonate
2005

Probiotics: protecting the intestinal ecosystem?
The Journal of pediatrics
2005

Neonatal necrotizing enterocolitis: an update.
Acta paediatrica (Oslo, Norway : 1992). Supplement
2005

Intestinal innate immunity: how does it relate to the pathogenesis of necrotizing enterocolitis.
Seminars in pediatric surgery
2005

Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium.
The Journal of nutrition
2005

Feeding intolerance in very-low-birthweight infants: what is it and what can we do about it?
Acta paediatrica (Oslo, Norway : 1992). Supplement
2005

Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of pediatric gastroenterology and nutrition
2005

Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor-alpha-induced interleukin-8 production in Caco-2 cells.
The Journal of nutrition
2005

Substitutes for glutamine in proliferation of rat intestinal epithelial cells.
Nutrition (Burbank, Los Angeles County, Calif.)
2004

Mechanism of glutamine-mediated amelioration of lipopolysaccharide-induced IL-8 production in Caco-2 cells.
Cytokine
2004

Glutamine regulates Caco-2 cell tight junction proteins.
American journal of physiology. Gastrointestinal and liver physiology
2004

Glutamine decreases lipopolysaccharide-induced intestinal inflammation in infant rats.
American journal of physiology. Gastrointestinal and liver physiology
2004

Effects of protein deprivation on growth and small intestine morphology are not improved by glutamine or glutamate in gastrostomy-fed rat pups.
Journal of pediatric gastroenterology and nutrition
2004

Artificial rearing of mouse pups: development of a mouse pup in a cup model.
Pediatric research
2004

Nutrition of premature and critically ill neonates.
Nestle Nutrition workshop series. Clinical & performance programme
2003

Nutrition in the neonatal intensive care unit: how do we reduce the incidence of extrauterine growth restriction?
Journal of perinatology : official journal of the California Perinatal Association
2003

Immunonutrients and neonates.
European journal of pediatrics
2003

Glutamine supports recovery from loss of transepithelial resistance and increase of permeability induced by media change in Caco-2 cells.
The Journal of nutritional biochemistry
2003

Glutamine supplements in premature infants: why and how.
Journal of pediatric gastroenterology and nutrition
2003

Glutamine decreases lipopolysaccharide-induced IL-8 production in Caco-2 cells through a non-NF-kappaB p50 mechanism.
Cytokine
2003

Glutamine and barrier function in cultured Caco-2 epithelial cell monolayers.
The Journal of nutrition
2003

Enteral glutamine supplementation and morbidity in low birth weight infants.
The Journal of pediatrics
2003

Update on host defense and immunonutrients.
Clinics in perinatology
2002

Indomethacin, dexamethasone, and intestinal damage in infant rats.
Journal of pediatric gastroenterology and nutrition
2002

Glutamine: clinical applications and mechanisms of action.
Current opinion in clinical nutrition and metabolic care
2002

Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology.
Pediatric research
2002

Glutamine metabolism in the fetus and critically ill low birth weight neonate.
Advances in pediatrics
2002

Arginine supplementation and the prevention of necrotizing enterocolitis in very low birth weight infants.
The Journal of pediatrics
2002

Glutamine in the fetus and critically ill low birth weight neonate: metabolism and mechanism of action.
The Journal of nutrition
2001

Necrotizing enterocolitis: pathophysiology and prevention.
JPEN. Journal of parenteral and enteral nutrition
1999

Inhibition of glutamine synthetase decreases proliferation of cultured rat intestinal epithelial cells.
The Journal of nutrition
1999

Glutamine synthetase: a key enzyme for intestinal epithelial differentiation?
JPEN. Journal of parenteral and enteral nutrition
1999

Glutamine supplementation in low-birth-weight infants: mechanisms of action.
JPEN. Journal of parenteral and enteral nutrition
1999

Enteral glutamine supplementation for very-low-birth-weight infants decreases hospital costs.
JPEN. Journal of parenteral and enteral nutrition
1998

Glutamine metabolism in very low birth weight infants.
Pediatric research
1997

Characterization of glutamine synthetase transcript, protein, and enzyme activity in the human placenta.
Placenta
1997

Ontogeny of glutamine synthetase in rat small intestine.
Pediatric research
1996

Nutrient absorption in the preterm neonate.
Clinics in perinatology
1996

Necrotizing enterocolitis: the search for a unifying pathogenic theory leading to prevention.
Pediatric clinics of North America
1996

Glutamine nutrition and metabolism: where do we go from here ?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
1996

Enteral glutamine supplementation for the very low birthweight infant: plasma amino acid concentrations.
The Journal of nutrition
1996

Characterization of glutaminase in the developing rat small intestine.
The Journal of nutrition
1996

Localization of rat small intestine glutamine synthetase using immunofluorescence and in situ hybridization.
JPEN. Journal of parenteral and enteral nutrition
1995

Ontogeny of small intestinal glutaminase and glutamine synthetase in the rat: response to dexamethasone.
Biology of the neonate
1993

Meconium passage in very-low-birth-weight infants.
JPEN. Journal of parenteral and enteral nutrition
1993

The role of dietary cholesterol in infants.
Comprehensive therapy
1992

Gastrointestinal priming prior to full enteral nutrition in very low birth weight infants.
Journal of pediatric gastroenterology and nutrition
1992

Effect of cholesterol deprivation on piglet small intestine and serum lipids.
Journal of pediatric gastroenterology and nutrition
1991

Scientifically-based strategies for nutrition of the high-risk low birth weight infant.
European journal of pediatrics
1990

Ontogeny of prostaglandin E1 receptor binding in rat small intestine.
Prostaglandins, leukotrienes, and essential fatty acids
1990

Localization and characterization of prostaglandin E1 receptors in rat small intestine.
Prostaglandins, leukotrienes, and essential fatty acids
1989

Functional development of the fetal gastrointestinal tract.
Seminars in perinatology
1989

Factors associated with age of onset of necrotizing enterocolitis.
American journal of perinatology
1989

Determination of extracellular fluid volume using impedance measurements.
Critical care medicine
1989

Changes in phospholipid and cholesterol concentrations of the rat microvillus membrane during maturation.
Journal of pediatric gastroenterology and nutrition
1989

Prostaglandin concentrations in human milk.
The American journal of clinical nutrition
1988

Alterations in piglet small intestine after cholesterol deprivation.
Pediatric research
1987

Research Interests

Nutrition and the GI environment in the neonate have major effects not only during infancy, but for the entire lifetime of the individual, and this can even span generations due to epigenetic effects. Our lab has several ongoing projects that involve the requirements for certain amino acids such as glutamine and arginine in very low birthweight infants, the effect of various nutrients on subsequent development of Type 1 and Type 2 diabetes, the effect of the intestinal commnensal microflora and probiotics on intestinal development, and the effects of novel nutritional agents on retinal diseases such as retinopathy of prematurity. Our work spans from evaluation of basic mechanisms of nutrients in cell cultures, studies in animal models and translation of these to and from studies in human infants.