Josef Neu, M.D. - Research & Publications | UF Health, University of Florida Health
Josef Neu, M.D.

Josef Neu, M.D. - Research & Publications

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Publications

The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes.
Neonatology
2018

Nih Consensus Development Conference Statement: Inhaled Nitric-Oxide Therapy for Premature Infants
Pediatrics
2011

Nonadministration of Routine Probiotics Unethical-Really?
Pediatrics
2010

Nutritional Strategies and Gut Microbiota Composition As Risk Factors for Necrotizing Enterocolitis in Very-Preterm Infants
American Journal of Clinical Nutrition
2017

Probiotics in Newborns and Children
Pediatric Clinics of North America
2017

What Are Optimal Cesarean Section Rates in the US and How Do We Get There? a Review of Evidence-Based Recommendations and Interventions
Journal of Womens Health
2017

Epigenetic Matters: the Link Between Early Nutrition, Microbiome, and Long-Term Health Development
Frontiers in Pediatrics
2017

Intestinal Microbiota Studies in Preterm Infants
Journal of Pediatric Gastroenterology and Nutrition
2016

Factors Influencing Gastrointestinal Tract and Microbiota Immune Interaction in Preterm Infants
Pediatric Research
2015

Early Factors Leading To Later Obesity: Interactions of the Microbiome, Epigenome, and Nutrition
Current Problems in Pediatric and Adolescent Health Care
2015

Preterm Infant Nutrition, Gut Bacteria, and Necrotizing Enterocolitis
Current Opinion in Clinical Nutrition and Metabolic Care
2015

Reply - Gastric Residuals, Feeding Intolerance, and Nectrotizing Enterocolitis in Preterm Infants
Pediatrics and Neonatology
2015

Aspiration and Evaluation of Gastric Residuals in the Neonatal Intensive Care Unit State of the Science
Journal of Perinatal and Neonatal Nursing
2015

Probiotics and Necrotizing Enterocolitis
Clinics in Perinatology
2014

Gastric Residual Evaluation in Preterm Neonates: a Useful Monitoring Technique Or a Hindrance?
Pediatrics and Neonatology
2014

The Infant Intestinal Microbiome: Friend Or Foe (Vol 86, Pg S67, 2010)
Early Human Development
2014

Manipulation of the Intestinal Microbiome in Newborn Infants
Advances in Nutrition
2014

Effect of Intestinal Microbial Ecology On the Developing Brain
Jama Pediatrics
2013

Feeding the Preterm Infant: Opportunities and Challenges of Bringing Science To the Bedside
Journal of Pediatrics
2013

Intestinal Mucosal Defense System, Part 2. Probiotics and Prebiotics
Journal of Pediatrics
2013

Intestinal Mucosal Defense System, Part 1. Consensus Recommendations for Immunonutrients
Journal of Pediatrics
2013

Gastrointestinal Function Development and Microbiota
Italian Journal of Pediatrics
2013

Nutrition Support of Neonatal Patients At Risk for Necrotizing Enterocolitis: Response To Fallon Et Al (2012)
Journal of Parenteral and Enteral Nutrition
2013

Microbial Cell Components Induced Tolerance To Flagellin-Stimulated Inflammation Through Toll-Like Receptor Pathways in Intestinal Epithelial Cells
Cytokine
2012

Arginyl-Glutamine Dipeptide Or Docosahexaenoic Acid Attenuate Hyperoxia-Induced Lung Injury in Neonatal Mice
Nutrition
2012

Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions
Journal of Mammary Gland Biology and Neoplasia
2012

Arginyl-Glutamine Dipeptide Or Docosahexaenoic Acid Attenuates Hyperoxia-Induced Small Intestinal Injury in Neonatal Mice
Journal of Pediatric Gastroenterology and Nutrition
2012

Baby and Breast: a Dynamic Interaction
Pediatric Research
2012

Cesarean Versus Vaginal Delivery: Long-Term Infant Outcomes and the Hygiene Hypothesis
Clinics in Perinatology
2011

Necrotizing Enterocolitis Reply
New England Journal of Medicine
2011

Routine Probiotics for Premature Infants: Let's Be Careful!
Journal of Pediatrics
2011

The Intestinal Microbiome of Infants and the Use of Probiotics
Current Opinion in Pediatrics
2011

The Developing Intestinal Microbiome and Its Relationship To Health and Disease in the Neonate
Journal of Perinatology
2011

Inhibition of Type 1 Diabetes Correlated To a Lactobacillus Johnsonii N6.2-Mediated Th17 Bias
Journal of Immunology
2011

Early Postnatal Nutrition and Programming of the Preterm Neonate
Nutrition reviews
2011

Probiotics for Pregnant Women and Preterm Neonates
American Journal of Clinical Nutrition
2011

Long-Term Effects of Neonatal Glutamine-Enriched Nutrition in Very-Low-Birth-Weight Infants
Nutrition reviews
2011

Medical Progress: Necrotizing Enterocolitis.
New England Journal of Medicine
2011

Monitoring Technologies in the Neonatal Intensive Care Unit: Implications for the Detection of Necrotizing Enterocolitis
Journal of Perinatology
2010

Butyrate and Type 1 Diabetes Mellitus: Can We Fix the Intestinal Leak?
Journal of Pediatric Gastroenterology and Nutrition
2010

The Intestinal Microbiome: Relationship To Type 1 Diabetes
Endocrinology and Metabolism Clinics of North America
2010

The Infant Intestinal Microbiome: Friend Or Foe?
Early Human Development
2010

Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee On Nutrition
Journal of Pediatric Gastroenterology and Nutrition
2010

The intestinal microbiome: relationship to type 1 diabetes.
Endocrinology and Metabolism Clinics of North America
2010

Intestinal Microbial Ecology in Premature Infants Assessed With Non-Culture-Based Techniques
Journal of Pediatrics
2010

Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota
Journal of Biomedicine & Biotechnology
2010

Maternal Separation in the Neonatal Period Decreases Adipose Gr and 11 Beta Hsd Mrna in the Adult Rat
Journal of Investigative Medicine
2010

Potential Roles and Clinical Utility of Prebiotics in Newborns, Infants, and Children: Proceedings From a Global Prebiotic Summit Meeting, New York City, June 27-28, 2008
Journal of Pediatrics
2009

Probiotics and Prevention of Necrotizing Enterocolitis
Early Human Development
2009

Probiotic Microbes: Do They Need To Be Alive To Be Beneficial?
Nutrition reviews
2009

Live and Heat-Killed Lactobacillus Rhamnosus Gg: Effects On Proinflammatory and Anti-Inflammatory Cytokines/Chemokines in Gastrostomy-Fed Infant Rats
Pediatric Research
2009

Use of Nutrition To Prevent Stress-Induced Immunosuppression in the Pediatric Intensive Care Unit: a Clinical Trials Minefield
Journal of Parenteral and Enteral Nutrition
2009

Is It Time To Stop Starving Premature Infants?
Journal of Perinatology
2009

50 Years Ago in the Journal of Pediatrics Lactic Acid Milk in the Feeding of Premature Infants
Journal of Pediatrics
2009

Biomarkers for Infants At Risk for Necrotizing Enterocolitis: Clues To Prevention?
Pediatric Research
2009

Glutamine Deprivation Alters Intestinal Tight Junctions Via a Pi3-K/Akt Mediated Pathway in Caco-2 Cells
Journal of Nutrition
2009

Potential of Immunomodulatory Agents for Prevention and Treatment of Neonatal Sepsis
Journal of Perinatology
2009

Metabolic Effects of Different Protein Intakes After Short Term Undernutrition in Artificially Reared Infant Rats
Early Human Development
2009

Live and Ultraviolet-Inactivated Lactobacillus Rhamnosus Gg Decrease Flagellin-Induced Interleukin-8 Production in Caco-2 Cells
Journal of Nutrition
2008

Intestinal Microbiota Development in the Premature Neonate: Establishment of a Lasting Commensal Relationship?
Nutrition reviews
2008

Neonatal Formula Feeding Leads To Immunological Alterations in An Animal Model of Type 1 Diabetes
Pediatric Research
2008

A roadmap for understanding and preventing necrotizing enterocolitis.
Current Gastroenterology Reports
2008

Microbes and the developing gastrointestinal tract.
Nutrition in Clinical Practice
2007

Postnatal nutrition and adult health programming.
Seminars in Fetal \& Neonatal Medicine
2007

Pathophysiology of glutamine and glutamate metabolism in premature infants.
Current Opinion in Clinical Nutrition and Metabolic Care
2007

Gastrointestinal maturation and implications for infant feeding.
Early Human Development
2007

Perinatal and neonatal manipulation of the intestinal microbiome: a note of caution.
Nutrition reviews
2007

Arginine supplementation for neonatal necrotizing enterocolitis: are we ready?
British Journal of Nutrition
2007

Gastrointestinal development and meeting the nutritional needs of premature infants.
American Journal of Clinical Nutrition
2007

NICHD: AAP workshop on neonatology research and training areas of research in neonatal gastroenterology.
Journal of Perinatology
2006

Gastrointestinal maturation and feeding.
Seminars in Perinatology
2006

Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of Pediatric Gastroenterology and Nutrition
2005

The 'myth' of asphyxia and hypoxia-ischemia as primary causes of necrotizing enterocolitis.
Biology of the Neonate Foetal and Neonatal Research
2005

Artificial rearing of mouse pups: development of a mouse pup in a cup model.
Pediatric Research
2004

Glutamine: clinical applications and mechanisms of action.
Current Opinion in Clinical Nutrition and Metabolic Care
2002

Glutamine in the fetus and critically ill low birth weight neonate: metabolism and mechanism of action.
Journal of Nutrition
2001

Gastrointestinal Priming Prior to Full Enteral Nutrition in Very Low Birthweight Infants
Journal of Pediatric Gastroenterology and Nutrition
1992

Research Interests

Nutrition and the GI environment in the neonate have major effects not only during infancy, but for the entire lifetime of the individual, and this can even span generations due to epigenetic effects. Our lab has several ongoing projects that involve the requirements for certain amino acids such as glutamine and arginine in very low birthweight infants, the effect of various nutrients on subsequent development of Type 1 and Type 2 diabetes, the effect of the intestinal commnensal microflora and probiotics on intestinal development, and the effects of novel nutritional agents on retinal diseases such as retinopathy of prematurity. Our work spans from evaluation of basic mechanisms of nutrients in cell cultures, studies in animal models and translation of these to and from studies in human infants.