Marcus Muehlbauer, M.D.

Marcus Muehlbauer, M.D., Ph.D.

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Publications

Locoregional Effects Of Microbiota In A Preclinical Model Of Colon Carcinogenesis.
Cancer Research
2017

The Innate Immune Receptor Nlrx1 Functions As a Tumor Suppressor By Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals
Cell Reports
2016

Altered Intestinal Microbiota-Host Mitochondria Crosstalk in New Onset Crohn's Disease
Nature Communications
2016

Inflammasome-Independent Role of Aim2 in Suppressing Colon Tumorigenesis Via Dna-Pk and Akt
Nature Medicine
2015

The Microbiota Protects Against Ischemia/Reperfusion-Induced Intestinal Injury Through Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (Nod2) Signaling.
The American Journal Of Pathology
2014

Microbial Genomic Analysis Reveals the Essential Role of Inflammation in Bacteria-Induced Colorectal Cancer
Nature Communications
2014

Glass Microparticulate Ingestion: An Unusual And Difficult-To-Diagnose Cause Of Chronic Abdominal Pain.
Acg Case Reports Journal
2014

Vsl\#3 Probiotic Modifies Mucosal Microbial Composition But Does Not Reduce Colitis-Associated Colorectal Cancer
Scientific Reports
2013

Stochastic Changes Over Time and Not Founder Effects Drive Cage Effects in Microbial Community Assembly in a Mouse Model
The ISME Journal
2013

Oxymatrine Prevents Nf-Κb Nuclear Translocation And Ameliorates Acute Intestinal Inflammation.
Scientific Reports
2013

Epithelial Cell-Specific Myd88 Signaling Mediates Ischemia/Reperfusion-Induced Intestinal Injury Independent Of Microbial Status.
Inflammatory Bowel Diseases
2013

Intestinal Inflammation Targets Cancer-Inducing Activity Of The Microbiota.
Science (New York, N.Y.)
2012

A Cell Permeable Peptide Inhibitor Of Nfat Inhibits Macrophage Cytokine Expression And Ameliorates Experimental Colitis.
PLoS One
2012

Microbial Colonization Induces Dynamic Temporal And Spatial Patterns Of Nf-Κb Activation In The Zebrafish Digestive Tract.
Gastroenterology
2011

Tumor Necrosis Factor And Interferon-Gamma Down-Regulate Klotho In Mice With Colitis.
Gastroenterology
2010

Reduced Expression Of Fibroblast Growth Factor Receptor 2Iiib In Hepatocellular Carcinoma Induces A More Aggressive Growth.
The American Journal Of Pathology
2010

Tomato Lycopene Extract Prevents Lipopolysaccharide-Induced Nf-Kappab Signaling But Worsens Dextran Sulfate Sodium-Induced Colitis In Nf-Kappabegfp Mice.
PLoS One
2009

Modulation Of The Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility.
PLoS One
2009

Analysis Of Monocyte Chemotactic Protein-1 Gene Polymorphism In Patients With Spontaneous Bacterial Peritonitis.
World Journal of Gastroenterology
2009

Activated Hepatic Stellate Cells Promote Tumorigenicity Of Hepatocellular Carcinoma.
Cancer Science
2009

Role Of Tlr9 In Hepatic Stellate Cells And Experimental Liver Fibrosis.
Biochemical and Biophysical Research Communications
2008

Regulation And Functional Impact Of Lipopolysaccharide Induced Nod2 Gene Expression In The Murine Epididymal Epithelial Cell Line Pc1.
Immunology
2008

Interleukin-8 Expression Is Regulated By Histone Deacetylases Through The Nuclear Factor-Kappab Pathway In Breast Cancer.
Molecular Pharmacology
2008

Impaired Bcl3 Up-Regulation Leads To Enhanced Lipopolysaccharide-Induced Interleukin (Il)-23P19 Gene Expression In Il-10(-/-) Mice.
Journal of Biological Chemistry
2008

Microbial Host Interactions In Ibd: Implications For Pathogenesis And Therapy.
Current Gastroenterology Reports
2007

Gnotobiotic Il-10-/-;Nf-Kappa B(Egfp) Mice Reveal The Critical Role Of Tlr/Nf-Kappa B Signaling In Commensal Bacteria-Induced Colitis.
Journal of immunology (Baltimore, Md. : 1950)
2007

Repression Of Cytochrome P450 Activity In Human Hepatocytes In Vitro By A Novel Hepatotrophic Factor, Augmenter Of Liver Regeneration.
The Journal of pharmacology and experimental therapeutics
2006

Promoter-Hypermethylation Is Causing Functional Relevant Downregulation Of Methylthioadenosine Phosphorylase (Mtap) Expression In Hepatocellular Carcinoma.
Molecular Carcinogenesis
2006

Pd-L1 Is Induced In Hepatocytes By Viral Infection And By Interferon-Alpha And -Gamma And Mediates T Cell Apoptosis.
Journal Of Hepatology
2006

Zinc Finger Protein 267 Is Up-Regulated During The Activation Process Of Human Hepatic Stellate Cells And Functions As A Negative Transcriptional Regulator Of Mmp-10.
Biochemical and Biophysical Research Communications
2005

Strong Expression Of Methylthioadenosine Phosphorylase (Mtap) In Human Colon Carcinoma Cells Is Regulated By Tcf1/[Beta]-Catenin.
Laboratory Investigation; A Journal Of Technical Methods And Pathology
2005

Lack Of Association Between The Functional Cx3Cr1 Polymorphism V249I And Hepatocellular Carcinoma.
Oncology Reports
2005

In Situ Expression Patterns Of Melanoma Inhibitory Activity 2 In Healthy And Diseased Livers.
Liver International : Official Journal Of The International Association For The Study Of The Liver
2005

Different Effects Of A Cd14 Gene Polymorphism On Disease Outcome In Patients With Alcoholic Liver Disease And Chronic Hepatitis C Infection.
World Journal of Gastroenterology
2005

Characterization Of The Human Zinc Finger Protein 267 Promoter: Essential Role Of Nuclear Factor Y.
Biochimica Et Biophysica Acta-Molecular Basis of Disease
2005

Lps-Mediated Nfkappab Activation Varies Between Activated Human Hepatic Stellate Cells From Different Donors.
Biochemical and Biophysical Research Communications
2004

Differential Effects Of Deoxycholic Acid And Taurodeoxycholic Acid On Nf-Kappa B Signal Transduction And Il-8 Gene Expression In Colonic Epithelial Cells.
American Journal of Physiology-Gastrointestinal and Liver Physiology
2004

Activated Hepatic Stellate Cells Express Keratinocyte Growth Factor In Chronic Liver Disease.
American Journal of Pathology
2004

Polymorphism Of Monocyte Chemoattractant Protein 1 In Crohn'S Disease.
International Journal of Colorectal Disease
2003

A Novel Mcp-1 Gene Polymorphism Is Associated With Hepatic Mcp-1 Expression And Severity Of Hcv-Related Liver Disease.
Gastroenterology
2003

Detection Of Melanoma Cells In The Blood Of Melanoma Patients By Melanoma-Inhibitory Activity (Mia) Reverse Transcription-Pcr.
Clinical Cancer Research
1999

Research Interests

Dr. Mühlbauer’s overarching goal is to provide the best care available for patients suffering from inflammatory bowel disease (Crohn’s disease and ulcerative colitis), or IBD. Besides commercially available treatment options, the University of Florida participates in a variety of new and exciting clinical trials our patients can participate in. Dr. Mühlbauer also works very closely with UF’s cutting edge research labs to find a cure for IBD. Patients can support the development of potentially new treatments by allowing us to collect information from them in a clinical setting and provide extremely small tissue samples during their normally scheduled clinical procedures.
Dr. Mühlbauer believes improving the education of physicians in training is of the utmost importance. At UF, we take pride in educating the next generation of IBD physicians so that they can provide the best care to patients suffering from Crohn’s disease or ulcerative colitis in the future.