Mark Segal, M.D.

Mark S Segal, M.D., Ph.D.

(352) 265-4845

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Publications

Maternal Endothelial Function, Circulating Endothelial Cells and Endothelial Progenitor Cells in Pregnancies Conceived With or Without In Vitro Fertilization
American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2020

Graft-versus-host disease of the kidney
Hematology/oncology and stem cell therapy (Print)
2019

Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation
Journal of Colloid and Interface Science
2019

Development of a Personalized Diagnostic Model for Kidney Stone Disease Tailored to Acute Care By Integrating Large Clinical, Demographics and Laboratory Data: the Diagnostic Acute Care Algorithm - Kidney Stones (Daca-Ks)
Bmc Medical Informatics and Decision Making
2018

Computational Design and Experimental Characterization of a Novel Beta-Common Receptor Inhibitory Peptide

2018

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in Immunology
2018

Activation of the Beta-Common Receptor By Erythropoietin Impairs Acetylcholine-Mediated Vasodilation in Mouse Mesenteric Arterioles

2018

Using Organizational Philosophy to Create a Self-Sustaining Compensation Plan Without Harming Academic Missions
Academic Medicine
2017

Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury
The American Journal Of Pathology
2017

Comparison of Multiple Non-Invasive Methods of Measuring Cardiac Output During Pregnancy Reveals Marked Heterogeneity in the Magnitude of Cardiac Output Change Between Women

2017

Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis
Case Reports in Nephrology and Dialysis
2017

Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients
Journal of Clinical Hypertension
2016

Effects of Long-Term Type I Interferon on the Arterial Wall and Smooth Muscle Progenitor Cells Differentiation
Arteriosclerosis Thrombosis and Vascular Biology
2016

Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery
PubMed Central
2016

A Novel Mechanism for Generating the Interferon Signature in Lupus Opsonization of Dead Cells By Complement and Igm
Arthritis & Rheumatology
2016

The Effect of the Addition of Allopurinol on Blood Pressure Control in African Americans Treated With a Thiazide-Like Diuretic
Journal of the American Society of Hypertension
2015

Renal Function and Coronary Microvascular Dysfunction in Women With Symptoms/Signs of Ischemia
PLoS One
2015

Mild Renal Dysfunction and Long-Term Adverse Outcomes in Women With Chest Pain: Results From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2015

Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease
PLoS One
2015

Higher Levels of Adiponectin in Vascular Endothelial Cells Are Associated With Greater Brachial Artery Flow-Mediated Dilation in Older Adults
Experimental Gerontology
2015

Fiber Supplementation Lowers Plasma P-Cresol in Chronic Kidney Disease Patients
Journal of Renal Nutrition
2015

Early Angiogenic Balance and Adverse Long-Term Outcomes in Sepsis
Shock
2015

Cost and Mortality Associated With Postoperative Acute Kidney Injury
Annals of Surgery
2015

Vasoreparative Dysfunction of Cd34(+) Cells in Diabetic Individuals Involves Hypoxic Desensitization and Impaired Autocrine/Paracrine Mechanisms
PLoS One
2014

Uric Acid Inhibition of Dipeptidyl Peptidase IV in Vitro Is Dependent On the Intracellular Formation of Triuret
Experimental Cell Research
2014

Evidence for Impaired Maternal Circulatory Adaptations in Pregnancies Conceived Using Donor Eggs
Reproductive Sciences
2014

The Role of Uric Acid in the Pathogenesis of Human Cardiovascular Disease

2013

Racial and Socioeconomic Disparities in the Allocation of Expanded Criteria Donor Kidneys
Clinical Journal of the American Society of Nephrology
2013

Number and Function of Bone-Marrow Derived Angiogenic Cells and Coronary Flow Reserve in Women Without Obstructive Coronary Artery Disease: a Substudy of the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
PLoS One
2013

National Surgical Quality Improvement Program Underestimates the Risk Associated With Mild and Moderate Postoperative Acute Kidney Injury
Critical Care Medicine
2013

Mineralocorticoid Receptors Modulate Vascular Endothelial Function in Human Obesity
Clinical science.
2013

Mild Renal Insufficiency Predicts Mortality and Adverse Events in Women With Cardiac Ischemia, Independent of the Underlying Obstructive Coronary Artery Disease
Circulation
2013

Mild Renal Insufficiency Is An Independent Predictor of Coronary Microvascular Dysfunction Among Women With Symptoms/Signs of Ischemia: a Report From the Women's Ischemia Syndrome Evaluation (Wise)
Circulation
2013

Lupus Nephritis and End-Stage Kidney Disease
American Journal of the Medical Sciences
2013

Long-Term Type 1 Diabetes Influences Haematopoietic Stem Cells By Reducing Vascular Repair Potential and Increasing Inflammatory Monocyte Generation in a Murine Model

2013

Long-Term Administration of Type-I Interferon Leads To Premature Atherosclerosis
Circulation
2013

Foods With Added Fiber Lower Serum Creatinine Levels in Patients With Chronic Kidney Disease
Journal of Renal Nutrition
2013

Evaluation of Stability and Sensitivity of Cell Fluorescent Labels When Used for Cell Migration
Journal of Fluorescence
2013

Relaxin Increases Human Endothelial Progenitor Cell No and Migration and Vasculogenesis in Mice
Blood
2012

Effects of High-Fructose Corn Syrup and Sucrose On the Pharmacokinetics of Fructose and Acute Metabolic and Hemodynamic Responses in Healthy Subjects
Metabolism-Clinical and Experimental
2012

Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine
2012

Creatinine Clearance Predicts Poor Outcome in Emergency Department Presentation of Pediatric Sepsis
Critical Care Medicine
2012

Apolipoprotein L1 Risk Variants Underlie Racial Disparities in Lupus Nephritis-Induced End-Stage Renal Disease
Arthritis and Rheumatism
2012

Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries Via Pi3 Kinase and Nitric Oxide
Endocrinology
2011

Frequent Coexistence of Anti-Topoisomerase I and Anti-U1Rnp Autoantibodies in African American Patients Associated With Mild Skin Involvement: a Retrospective Clinical Study
Arthritis Research & Therapy
2011

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism
2011

Monocyte Surface Expression of Fc Gamma Receptor Ri (Cd64), a Biomarker Reflecting Type-I Interferon Levels in Systemic Lupus Erythematosus
Arthritis Research & Therapy
2010

Endothelial Progenitor Cells and Endothelial Vesicles - What Is the Significance for Patients With Chronic Kidney Disease?
Blood Purification
2010

Endogenous Type-I Interferon Activity Is Not Associated With Depression Or Fatigue in Systemic Lupus Erythematosus
Journal of Neuroimmunology
2010

Cryoglobulinemic Mpgn in a Patient With Scleroderma and Sjogren's Syndrome

2010

Urinary CD80 excretion increases in idiopathic minimal-change disease.
Journal of the American Society of Nephrology
2009

The Erythropoietin Heterodimeric Beta Common Receptor Is in a Complex With and Requires Vegfr2 for Downstream Signaling
Circulation
2009

Simultaneous Determination of Uric Acid Metabolites Allantoin, 6-Aminouracil, and Triuret in Human Urine Using Liquid Chromatography-Mass Spectrometry
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
2009

Role of Relaxin in Maternal Systemic and Renal Vascular Adaptations During Gestation

2009

Mechanisms of Relaxin-Induced Rapid Arterial Relaxation.
Reproductive Sciences
2009

Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, But Not Tubulointerstitial Injury, in Diabetic Enos Knockout Mice
The American Journal Of Pathology
2009

Long-Term Risk of Mortality and Acute Kidney Injury During Hospitalization After Major Surgery
Annals of Surgery
2009

Lambda Chops: Creation of Site-Directed Mutants in Insertable Fragments Utilizing Gateway(a (R)) Technology
Molecular Biotechnology
2009

Increased Expression of Fc Gamma Ri/Cd64 On Circulating Monocytes Parallels Ongoing Inflammation and Nephritis in Lupus
Arthritis Research & Therapy
2009

Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Endocrine Reviews
2009

Diabetic Retinopathy Is Associated With Bone Marrow Neuropathy and a Depressed Peripheral Clock
Journal of Experimental Medicine
2009

Citrulline Dependence of Anti-Cyclic Citrullinated Peptide Antibodies in Systemic Lupus Erythematosus as a Marker of Deforming/Erosive Arthritis

2009

Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients

2009

Acute Kidney Injury Is Associated With Increased Long-Term Mortality After Cardiothoracic Surgery
Circulation
2009

Tacrolimus Rescue Therapy in Resistant Or Relapsing Cases of Primary Glomerulonephritis
Journal of Nephrology
2008

No Unique Role for Fructose Sweeteners in Obesity Or Cardiorenal Disease - Reply
American Journal of Clinical Nutrition
2008

Long-Term Engraftmetn of Bone Marrow-Derived Cells in the Intimal Hyperplasia Lesion of Autologous Vein Grafts
The American Journal Of Pathology
2008

How Safe Is Fructose for Persons With Or Without Diabetes?
American Journal of Clinical Nutrition
2008

Carbon Monoxide and Nitric Oxide Mediate Cytoskeletal Reorganization in Microvascular Cells Via Vasodilator-Stimulated Phosphoprotein Phosphorylation - Evidence for Blunted Responsiveness in Diabetes
Diabetes
2008

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
American Journal of Clinical Nutrition
2007

Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
European Journal of Nutrition
2007

A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
Nephrology Dialysis Transplantation
2007

Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease.
Kidney International
2006

Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
Diabetes
2006

Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
Journal of the American Society of Nephrology
2005

Intimal exuberance: veins in jeopardy.
The American Journal Of Pathology
2003

Circulating endothelial cells: tea leaves for renal disease.
American Journal of Physiology-Renal Physiology
2002

Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity.
American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2001

Research Interests

Dr. Segal's research focuses on the mechanisms of the increased cardiovascular disease in patients with diabetes, chronic kidney disease, systemic lupus erythematosus (SLE), and women who have preeclampsia or preterm delivery. His hypothesis is that a key determinate of whether an individual will develop chronic kidney disease or atherosclerosis is the ability of the individual's endothelium to tolerate their level of blood pressure, glycemia, or other stressors to the endothelium.