Michael Clare-Salzler, M.D.

Michael J Clare-Salzler, M.D. - Research & Publications

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Publications

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Nutrients
2019

Multisite Investigation of Outcomes With Implementation of Cyp2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention
Jacc-Cardiovascular Interventions
2018

Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice.

2018

Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection.
Clinical Immunology
2018

Design and Rational for the Precision Medicine Guided Treatment for Cancer Pain Pragmatic Clinical Trial
Contemporary Clinical Trials
2018

Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway
Diabetes
2017

The Association Between Omega-3 Fatty Acid Biomarkers and Inflammatory Arthritis in An Anti-Citrullinated Protein Antibody Positive Population

2017

Omega-3 Fatty Acids Are Associated With a Lower Prevalence of Autoantibodies in Shared Epitope-Positive Subjects at Risk for Rheumatoid Arthritis
Annals of the Rheumatic Diseases
2017

Macrophage Integrins Modulate Response to Ultra-High Molecular Weight Polyethylene Particles and Direct Particle-Induced Osteolysis

2017

Institutional Profile: University of Florida Health Personalized Medicine Program
Pharmacogenomics
2017

Systemic Inflammatory Responses in Patients With Type 2 Diabetes With Chronic Periodontitis
Bmj Open Diabetes Research & Care
2016

Lower Omega-3 Fatty Acids Are Associated With the Presence of Anti-Cyclic Citrullinated Peptide Autoantibodies in a Population at Risk for Future Rheumatoid Arthritis: a Nested Case-Control Study

2016

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer From Marine Cyanobacteria

2016

A Cell-Based Microarray to Investigate Combinatorial Effects of Microparticle-Encapsulated Adjuvants on Dendritic Cell Activation
Journal of Materials Chemistry B
2016

Effect of Docosahexaenoic Acid Supplementation On Inflammatory Cytokine Levels in Infants At High Genetic Risk for Type 1 Diabetes

2015

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease
Diabetes Care
2015

A Combination Dual-Sized Microparticle System Modulates Dendritic Cells and Prevents Type 1 Diabetes in Prediabetic Nod Mice

2015

It's Time To Bring Dendritic Cell Therapy To Type 1 Diabetes

2014

Integrin-Directed Modulation of Macrophage Responses To Biomaterials

2014

Increased Ifn-Alpha-Producing Plasmacytoid Dendritic Cells (Pdcs) in Human Th1-Mediated Type 1 Diabetes: Pdcs Augment Th1 Responses Through Ifn-Alpha Production
Journal of Immunology
2014

Combinatorial Delivery of Immunosuppressive Factors To Dendritic Cells Using Dual-Sized Microspheres
Journal of Materials Chemistry B
2014

Clinical Pharmacogenetics Implementation: Approaches, Successes, and Challenges
American Journal of Medical Genetics. Part C: Seminars in Medical Genetics
2014

University of Florida and Shands Hospital Personalized Medicine Program: Clinical Implementation of Pharmacogenetics.
Pharmacogenomics
2013

Persistent Stat5 Phosphorylation and Epigenetic Dysregulation of Gm-Csf and Pgs2/Cox2 Expression in Type 1 Diabetic Human Monocytes
PLOS One
2013

Omega-3 Supplement Use Is Associated With a Reduced Risk of Anti-Cyclic Citrullinated Protein Positivity in a Population Without Rheumatoid Arthritis, But At Risk for Future Disease
Arthritis and Rheumatism
2013

Autologous Umbilical Cord Blood Infusion Followed By Oral Docosahexaenoic Acid and Vitamin D Supplementation for C-Peptide Preservation in Children With Type 1 Diabetes

2013

Anti-Lymphocyte Antibody-Based Immunotherapy in Type 1 Diabetes
Chinese Medical Journal
2013

Anti-Cd3 Antibody Treatment Induces Hypoglycemia and Super Tolerance To Glucose Challenge in Mice Through T Cell Activation
Journal of Immunology
2013

Total Synthesis of Grassystatin A, a Probe for Cathepsin E Function

2012

The Tyrphostin Agent Ag490 Prevents and Reverses Type 1 Diabetes in Nod Mice
PLOS One
2012

Pre-Transplant Myeloid Dendritic Cell Deficiency Associated With Cytomegalovirus Infection and Death After Kidney Transplantation

2012

Implementing Personalized Medicine: Development of a Cost-Effective Customized Pharmacogenetics Genotyping Array
Clinical Pharmacology & Therapeutics
2012

Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
Blood
2012

Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells in Nonobese Diabetic Mice
Bmc Immunology
2012

University of Florida Clinical and Translational Science Institute: Transformation and Translation in Personalized Medicine
Cts-Clinical and Translational Science
2011

Reduced Serum Vitamin D-Binding Protein Levels Are Associated With Type 1 Diabetes

2011

Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma
Thyroid
2011

Multifunctional Dendritic Cell-Targeting Polymeric Microparticles Engineering New Vaccines for Type 1 Diabetes
Human Vaccines
2011

Erythrocyte Membrane Omega-3 Fatty Acid Levels and Omega-3 Fatty Acid Intake Are Not Associated With Conversion To Type 1 Diabetes in Children With Islet Autoimmunity: the Diabetes Autoimmunity Study in the Young (Daisy)

2011

Adhesive Substrates Modulate the Activation and Stimulatory Capacity of Non-Obese Diabetic Mouse-Derived Dendritic Cells
Acta Biomaterialia
2011

The Modulation of Dendritic Cell Integrin Binding and Activation By Rgd-Peptide Density Gradient Substrates

2010

Hyper-Responsive Phenotype in Localized Aggressive Periodontitis

2010

Experimental Extracorporeal Photopheresis Therapy Significantly Delays the Development of Diabetes in Non-Obese Diabetic Mice

2010

Erythrocyte Membrane Fatty Acid Content in Infants Consuming Formulas Supplemented With Docosahexaenoic Acid (Dha) and Arachidonic Acid (Ara): An Observational Study
Maternal and Child Nutrition
2010

Dendritic Cell Deficiency Associated With Development of Bk Viremia and Nephropathy in Renal Transplant Recipients

2010

Rabbit Polyclonal Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses
Journal of Immunology
2009

Extracorporeal Photopheresis-Induced Immune Tolerance: a Focus On Modulation of Antigen-Presenting Cells and Induction of Regulatory T Cells By Apoptotic Cells
Current Opinion in Organ Transplantation
2009

Dendritic Cell Therapy for Prevention of Type 1 Diabetes: Role of Peptide Presentation On Immune Modulation

2009

Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation
2009

A High-Throughput Microparticle Microarray Platform for Dendritic Cell-Targeting Vaccines

2009

Murine Antithymocyte Globulin Therapy Alters Disease Progression in Nod Mice By a Time-Dependent Induction of Immunoregulation

2008

Infusion of UVB-treated splenic stromal cells induces suppression of beta cell antigen-specific T cell responses in NOD mice.
Journal of Autoimmunity
2008

Comparison Between Omega-3 and Omega-6 Polyunsaturated Fatty Acid Intakes as Assessed By a Food Frequency Questionnaire and Erythrocyte Membrane Fatty Acid Composition in Young Children
European Journal of Clinical Nutrition
2008

Apoptotic Non-Beta Cells Suppress Beta Cell Antigen-Reactive T Cells and Induce Beta Cell Antigen-Specific Regulatory T Cells Transfusion of Apoptotic Splenic Stromal Cells Prevents Type 1 Diabetes

2008

Adhesive Substrate-Modulation of Adaptive Immune Responses

2008

Truncated pStat5B is associated with the Idd4 locus in NOD mice.
Biochemical and Biophysical Research Communications
2007

Transfusion of apoptotic beta-cells induces immune tolerance to beta-cell antigens and prevents type 1 diabetes in NOD mice.

2007

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
Diabetes
2007

Dendritic cells post-maturation are reprogrammed with heightened IFN-gamma and IL-10.
Biochemical and Biophysical Research Communications
2007

Eicosanoid imbalance in the NOD mouse is related to a dysregulation in soluble epoxide hydrolase and 15-PGDH expression.
Annals of the New York Academy of Sciences
2006

The effects of renal transplantation on peripheral blood dendritic cells.
Clinical Transplantation
2005

Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages.
Journal of Autoimmunity
2005

Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of Immunology
2005

In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases.
Scandinavian Journal of Immunology
2005

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
Diabetes
2005

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus--a new surrogate measure of non-progression?

2004

IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes.
Journal of Autoimmunity
2004

Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes.
Annals of the New York Academy of Sciences
2002

Systemic infection of mice by wild-type but not Spv- Salmonella typhimurium is enhanced by neutralization of gamma interferon and tumor necrosis factor alpha.
Infection and Immunity
1997

Research Interests

  • Dr. Clare-Salzler's research focus is to establish the cellular, molecular, and genetic basis for the immunpathogenesis of Juvenile or Type I diabetes and other autoimmune endocrine diseases. He and his team have concentrated their efforts on the role of antigens such as glutamate decarboxylase (GAD) and the biology of antigen presenting cells as it relates to the generation of protective and pathogenic immune responses in an animal model of Type I diabetes, the non-obese diabetic mouse (NOD) as well as in humans with an established high risk for this disease.
  • Recent work has lead to the identification of a number of immunophenotypes in NOD mice and human subjects with a high risk for Type I diabetes. These immunophenotypes involve the regulation of prostaglandin metabolism in macrophages/monocytes and dysregulation of pathways involved in activation induced cell death in lymphocytes. Utilizing congenic mice we have identified chromosomal intervals that contribute to these phenotypes. They are currently evaluating candidate genes in these intervals and are also determining the role of TNF in the development of organ dysfunction, particularly liver injury, in a murine model of sepsis and inflammation. The team has defined that NOD mice are highly resistant to this form of liver injury in comparison to other standard strains of mice. They are currently dissecting the genetic contributions to this resistance using a congenic mouse approach.