Michael Bubb, M.D.

Michael R Bubb, M.D. - Research & Publications

(352) 265-4846

Request an Appointment

Publications

Muscarinic Type 3 Receptor Autoantibodies Are Associated With Anti-Ssa/Ro Autoantibodies in Sjogren's Syndrome
Journal of Immunological Methods
2016

Biochemical and Biophysical Properties of a Putative Hub Protein Expressed By Vaccinia Virus
Journal of Biological Chemistry
2013

Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism
2013

Potential, But Unobserved, Adverse Cardiovascular Effects From Endurance Exercise

2012

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?
Arthritis and Rheumatism
2012

Gender and Ethnicity Differences in the Prevalence of Scleroderma-Related Autoantibodies
Clinical Rheumatology
2011

Frequent Coexistence of Anti-Topoisomerase I and Anti-U1Rnp Autoantibodies in African American Patients Associated With Mild Skin Involvement: a Retrospective Clinical Study
Arthritis Research & Therapy
2011

Atypical Clinical Presentation of a Subset of Patients With Anti-Rna Polymerase III - Non-Scleroderma Cases Associated With Dominant Rna Polymerase I Reactivity and Nucleolar Staining
Arthritis Research & Therapy
2011

Identification of a Cofilin-Like Actin-Binding Site On Translationally Controlled Tumor Protein (Tctp)
FEBS Letters
2010

Changes in the Visiting Medical Student Clerkship Program At Mayo Clinic

2010

How depolymerization can promote polymerization: the case of actin and profilin.
BioEssays
2009

How Depolymerization Can Promote Polymerization: the Case of Actin and Profilin
BioEssays
2009

Genetically Elevated C-Reactive Protein and Vascular Disease.
New England Journal of Medicine
2009

Exogenous Thymosin Beta(4) Prevents Apoptosis in Human Intervertebral Annulus Cells in Vitro
Biotechnic and Histochemistry
2009

Air Pollution and Life Expectancy.
New England Journal of Medicine
2009

Upregulated Mir-146a Expression in Peripheral Blood Mononuclear Cells From Rheumatoid Arthritis Patients
Arthritis Research & Therapy
2008

Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism
2008

Effect of profilin on actin critical concentration: a theoretical analysis.
Biophysical Journal
2008

Effect of Profilin On Actin Critical Concentration: a Theoretical Analysis
Biophysical Journal
2008

Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism
2008

Thymosin beta4: actin regulation and more.
Annals of the New York Academy of Sciences
2007

Interactions between vacuolar H+-ATPases and microfilaments in osteoclasts.
Journal of Bioenergetics
2005

Regulation of endothelial nitric oxide synthase by the actin cytoskeleton.
American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2003

Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
Journal of Biological Chemistry
2003

Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
Journal of Biological Chemistry
2002

Profilin Interacts with the GPPPPP Sequences of Vasodilator- Stimulated Phosphoprotein (VASP): Implications for Actin-Based Listeria Motility

1997

Self-Assembly of the Brain MAP-2 Microtubule-Binding Region into Polymeric Structures Resembling Alzheimer Filaments
Biochemical and Biophysical Research Communications
1996

Assembly of MAP-2c and MTBR Fragments into Polymers Resembling Paired Helical Filaments
Journal of Biological Chemistry
1996

Research Interests

RESEARCH INTERESTS

Dr. Bubb's laboratory studies the regulation of actin polymerization in cell motility. We investigate the cell biology and biochemistry of actin-binding proteins specifically as they pertain to such topics as apoptosis, angiogenesis, immunology and cancer biology. We also study pharmacologic agents that affect actin polymerization. We use a variety of biophysical techniques to answer specific questions regarding mechanisms controlling cell motility, including time-dependent fluorescence spectroscopy and analytical ultracentrifugation.

Specific ongoing projects include (1) a study of the MARCKS protein as it relates to neurodevelopment, synaptic plasticity and memory, (2) a study of the structure and immunomodulatory properties of thymosin 4, and (3) the development of cancer chemotherapeutic agents that target the actin cytoskeleton, and (4) a study of predicted outcomes and response to therapy in rheumatoid arthritis based on the role of TNF-alpha in cytoskeletal dynamics.

ABAKUS or Actin Binding Activities and Kinetic solUtionS, an interactive model of actin polymerization developed by our laboratory.

ACTIVE RESEARCH STUDIES

A randomized, double-blind, placebo-controlled multicenter study of secukinumab to evaluate the safety, tolerability and efficacy up to 2 years in patients with active nonradiographic axial spondyloarthritis.

  • The purpose of this study is to determine whether the use of the study drug, secukinumab, can help treat patients who have non-radiographic ankylosing spondylitis. This study is currently actively enrolling. Further information is available at www.clinicaltrials.gov.
  • Physicians and patients are welcome to contact us for more information.
  • The principal investigator, Dr. Michael Bubb, can be reached at the rheumatology office, 352.294.8202.

Active Research Studies