A granuloma is a clump of cells that forms when the immune system tries to fight off a harmful substance but cannot remove it from the body.
A necrotizing granuloma is an area of inflammation in which tissue has died. Necrotizing means dying or decaying.
Tuberculosis and Wegener granulomatosis are conditions that cause necrotizing granulomas.
Reginato AM, Yang NB. Granulomatosis with polyangiitis. In: Ferri FF, ed. Ferri's Clinical Advisor 2018. Philadelphia, PA: Elsevier; 2018:532-534.