Philip A Efron, M.D., FACS, FCCM - Research & Publications | UF Health, University of Florida Health
Philip Efron, M.D.

Philip A Efron, M.D., FACS, FCCM - Research & Publications

1-352-733-0111

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Publications

Persistent Injury-Associated Anemia in Aged Rats
Experimental Gerontology
2018

Successful Nonoperative Management of Uncomplicated Appendicitis: Predictors and Outcomes
Journal of Surgical Research
2018

Characterization of Hypoalbuminemia Following Temporary Abdominal Closure
Journal of Trauma and Acute Care Surgery
2017

Unique Transcriptomic Response to Sepsis Is Observed Among Patients of Different Age Groups
Plos One
2017

Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure
Shock
2017

Persistent Injury-Associated Anemia: the Role of the Bone Marrow Microenvironment
Journal of Surgical Research
2017

Early Bronchoalveolar Lavage for Intubated Trauma Patients With Tbi or Chest Trauma
Journal of Critical Care
2017

Improved Survival After Induction of Sepsis By Cecal Slurry in Pd-1 Knockout Murine Neonates
Surgery
2017

Human Myeloid-Derived Suppressor Cells Are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock
Annals of Surgery
2017

Clonidine Reduces Norepinephrine and Improves Bone Marrow Function in a Rodent Model of Lung Contusion, Hemorrhagic Shock, and Chronic Stress
Surgery
2017

Routine Surveillance Cholangiography After Percutaneous Cholecystostomy Delays Drain Removal and Cholecystectomy
Journal of Trauma and Acute Care Surgery
2017

Murine Models of Sepsis and Trauma: Can We Bridge the Gap?
ILAR Journal
2017

Sex-Based Differences in the Genomic Response, Innate Immunity, Organ Dysfunction, and Clinical Outcomes After Severe Blunt Traumatic Injury and Hemorrhagic Shock
Journal of Trauma and Acute Care Surgery
2016

Preoperative Assessment of the Risk for Multiple Complications After Surgery
Surgery
2016

Mortality and Cost of Acute and Chronic Kidney Disease After Vascular Surgery
Annals of Vascular Surgery
2016

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced By Severe Shock and Trauma in the Aged
Journal of Immunology
2015

Clostridium Difficile Infections After Blunt Trauma: a Different Patient Population?
Surgical Infections
2015

Human Myeloid Derived Suppressor Cells Induce Immune Suppression After Severe Sepsis
Shock
2015

Early Angiogenic Balance and Adverse Long-Term Outcomes in Sepsis
Shock
2015

Sphingosine-1-Phospate/S1P Receptors Modulate Hematopoietic Progenitor Cell Mobilization Following Trauma/Hemorrhagic Shock
Shock
2015

The Genomic Response After Burn Injury Predicts Organ Dysfunction and Mortality
Shock
2015

Alum as a Preventative Therapy Abolishes Mortality in Murine Neonatal Sepsis By Improving Effector Cell Function and Bacterial Clearance
Shock
2015

Cost and Mortality Associated With Postoperative Acute Kidney Injury
Annals of Surgery
2015

Sepsis Enhances Myeloid Cell Function and Immune Protection From Secondary Listeria Infection Through Tnf Alpha Signaling
Shock
2015

Blunt Trauma Releases Cell Free Nucleic Acids, But Its Prognostic Relevance Does Not Surface Until the Following Day.
Shock
2015

Patterns of Gene Expression Among Murine Models of Hemorrhagic Shock Trauma and Sepsis
Shock
2015

Improved Emergency Myelopoiesis and Survival in Neonatal Sepsis By Caspase-1/11 Ablation
Immunology
2015

Delayed Emergency Myelopoiesis Following Polymicrobial Sepsis in Neonates
Innate Immunity
2015

Advanced Age Is Associated With Worsened Outcomes and a Unique Genomic Response in Severely Injured Patients With Hemorrhagic Shock
Critical Care
2015

Trif-Dependent Innate Immune Activation Is Critical for Survival To Neonatal Gram-Negative Sepsis
Journal of Immunology
2015

The Lung Neutrophil Transcriptome After Trauma Influences the Worse Outcomes of the Old To Pneumonia
Critical Care Medicine
2014

Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Intensive Care Unit
American Surgeon
2014

Genomic Analysis of Individual Leukocyte Populations After Severe Trauma
Shock
2014

Enhanced Protective Immunity and Extramedullary Myelopoiesis in Neonatal Sepsis By Ablation of Caspase-1 Signaling
Shock
2014

Inadequate Pmn Chemokine Receptor Expression After Polymicrobial Abdominal Sepsis Contributes To Defective Pmn Chemotaxis in the Aged
Shock
2014

A Comparison of the Leukocyte Genomic Responses To Sterile Or Infectious Inflammation
Shock
2014

The Female Transcriptomic Response After Severe Trauma Is Different From That of Males
Shock
2014

Use of Alum as An Innate Immune Adjuvant in Neonatal Sepsis: What Is the Role of Caspase 1?
Shock
2014

Advanced Age Is An Independent Predictor of Complicated Outcomes and Mortality Among Severely Injured Pateints in Hemorrhagic Shock
Shock
2014

Host Responses To Sepsis Vary in Different Low-Lethality Murine Models
Plos One
2014

Computer Versus Paper System for Recognition and Management of Sepsis in Surgical Intensive Care
Journal of Trauma and Acute Care Surgery
2014

National Surgical Quality Improvement Program Underestimates the Risk Associated With Mild and Moderate Postoperative Acute Kidney Injury
Critical Care Medicine
2013

Candida Albicans Necrotizing Soft Tissue Infection a Case Report and Literature Review of Fungal Necrotizing Soft Tissue Infections
Annals of Plastic Surgery
2013

Is There Value in Plasma Cytokine Measurements in Patients With Severe Trauma and Sepsis?
Methods
2013

Development of a Genomic Metric That Can Be Rapidly Used To Predict Clinical Outcome in Severely Injured Trauma Patients
Critical Care Medicine
2013

Acute Kidney Injury Is Associated With Early Cytokine Changes After Trauma
Journal of Trauma and Acute Care Surgery
2013

Soybean Oil: a Potentially New Intravascular Perfusate
Perfusion-Uk
2013

A Genomic Analysis of Clostridium Difficile Infections in Blunt Trauma Patients
Journal of Trauma and Acute Care Surgery
2013

Successful Implementation of a Packed Red Blood Cell and Fresh Frozen Plasma Transfusion Protocol in the Surgical Intensive Care Unit
Critical Care Medicine
2012

Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine
2012

Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Icu
Critical Care Medicine
2012

Incidence and Timing of Space Respiratory Isolates in Patients Admitted To a Trauma-Orthopedics-Vascular Intensive Care Unit
Critical Care Medicine
2012

The Acute Immunological Response To Blood Transfusion Is Influenced By Polymicrobial Sepsis
Shock
2012

Persistent Inflammation and Immunosuppression: a Common Syndrome and New Horizon for Surgical Intensive Care
Journal of Trauma and Acute Care Surgery
2012

Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures
Annals of Surgery
2012

Obese Patients Show a Depressed Cytokine Profile Following Severe Blunt Injury
Shock
2012

A Regionalised Strategy for Improving Motor Vehicle-Related Highway Driver Deaths Using a Weighted Averages Method
Injury Prevention
2012

Hypdxia-Induced Angiogenic Factors, Progenitor Endothelial Cells and Urinary Hypdxic Markers as Early Markers of Endothelial Injury in Hemorrhagic Shock (Hypper)
Shock
2012

Identification and Description of a Novel Murine Model for Polytrauma and Shock
Shock
2012

A Novel Role for Tumor-Induced Expansion of Myeloid Derived Cells in Host Resistance and Cancer Cachexia
Shock
2012

Loss of Myd88 Or Trif Does Not Impact Survival To Neonatal Polymicrobial Sepsis
Shock
2012

Microfluidics-Based Capture of Human Neutrophils for Expression Analysis in Blood and Bronchoalveolar Lavage
Modern Pathology
2011

A Pilot Study On the Randomization of Inferior Vena Cava Filter Placement for Venous Thromboembolism Prophylaxis in High-Risk Trauma Patients
Journal of Trauma
2011

B Cells Enhance Early Innate Immune Responses During Bacterial Sepsis
Journal of Experimental Medicine
2011

Critical Role for Cxc Ligand 10/Cxc Receptor 3 Signaling in the Murine Neonatal Response To Sepsis
Infection and Immunity
2011

Neutrophil Mobilization From the Bone Marrow During Polymicrobial Sepsis Is Dependent On Cxcl12 Signaling
Journal of Immunology
2011

Mopeds and Scooters: Crash Outcomes in a High Traffic State
Journal of Trauma
2011

Murine Blood Transfusion Induces Immune Dysregulation During Sepsis
Shock
2011

The Potential Influence of Common Viral Infections Diagnosed During Hospitalization Among Critically Ill Patients in the United States
Plos One
2011

A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma
Molecular Medicine
2011

Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality To Secondary Infection
Journal of Immunology
2011

American College of Surgeons National Surgical Quality Improvement Program Underestimates the Risk Associated With Mild and Moderate Postoperative Aki
Critical Care Medicine
2010

The Role of Ip-10/Cxcr3 in the Neonatal Immune Response To a Septic Insult
Shock
2010

Alternative Modes of Transportation and Their Crash Oucomes
Shock
2010

Transfusion-Induced Immunosuppression Varies With Blood Age
Shock
2010

Major Hepatectomy Induces Phenotypic Changes in Circulating Dendritic Cells and Monocytes
Journal of Clinical Immunology
2009

Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes.
Journal of Clinical Immunology
2009

Polymicrobial Sepsis Activates Th1 and Protects Against Listeria Infection
Shock
2009

Pseudomonas Eradication After Sepsis Depends On Adequate Neutrophil Function
Shock
2009

Myeloid-Derived Suppressor Cell Expansion Requires Cxcl12-Induced Progenitor Cell Development and Is Necessary for Survival
Shock
2009

Mesenteric Lipoblastoma: a Rare Location in Children
Journal of Pediatric Surgery
2008

Pediatric Basal Cell Carcinoma: Case Reports and Literature Review
Journal of Pediatric Surgery
2008

Role of Toll-Like Receptors in the Development of Sepsis
Shock
2008

The effects of renal transplantation on peripheral blood dendritic cells.
Clinical Transplantation
2005

Research Interests

Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation. He is currently one of the principal investigators for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients.