(ACTION) Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas
Purpose
It is believed that the body's immune system protects the body by attacking and killing tumor cells. T-lymphocytes (T-cells) are part of the immune system and can attack when they recognize special proteins on the surface of tumors. In most patients with advanced cancer, T-cells are not stimulated enough to kill the tumor.
In this research study, we will use a patient's tumor to make a vaccine which we hope will stimulate T-cells to kill tumor cells and leave normal cells alone.
Eligibility
- 3 - 21 years old
- Patients with histologically confirmed WHO Grade III or IV malignant glioma
- Scheduled for definitive surgical resection of suspected HGG (biopsy only subjects are not eligible for this study)
- 352.273.6971
- marcia.hodik@neurosurgery.ufl.edu
Procedures
- Drug: Temozolomide
- Drug type: Chemotherapy
Full details regarding study procedures can be explained by the study coordinator Marcia Hodik:
- 352.273.6971
- marcia.hodik@neurosurgery.ufl.edu
Age
Gender
Can be done from home
Keywords
Brain Tumors, Pediatric Brain Tumors, Brain Tumor, Brain tumor - children, GliomaPrincipal Investigator
Elias Sayour, MD, PhDDepartment
Contact Information
marcia.hodik@neurosurgery.ufl.edu
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