Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease (AIH in ALS)


Participants will complete a single, 45 minute session of acute intermittent hypoxia (low oxygen air) and a single, 45 minute session of sham acute intermittent hypoxia (normal, room air). Each participant will have the choice to participate in a third, optional visit that combines acute intermittent hypoxia (AIH) with consumption of a low dose of caffeine. Breathing function, muscle activity, and heart activity will be monitored before, during, and after all procedures for all visits.

Healthy controls and ALS patients will complete the AIH and sham AIH sessions and both will have the option to participate in the third, AIH + caffeine visit

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  • Participants will complete a single 45 minute session of acute intermittent hypoxia (AIH), as well as, the 45 minute sham AIH session, consisting of breathing air with normal oxygen levels. Breathing, muscle activity and heart activity will be monitored before, during and after both procedures.
  • Both health control volunteers and ALS patients will complete the procedure above

For more details about study procedures, please contact Jessica Ehrbar:


  • For adults ages 21 - 75 years old
  • A healthy adult OR clinical diagnosis of ALS
  • Baseline FVC >60% predicted for age, sex, and height

Additional eligibility criteria apply, please contact Jessica Ehrbar:



Can be done from home



Physical Therapy, ALS, ALS - resources, Amyotrophic lateral sclerosis

Principal Investigator

Barbara Smith, PT, PhD



Contact Information


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