Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor


The purpose of this research study is to test the effectiveness of Responsive Deep Brain Stimulation (R-DBS) for Essential Tremor (ET). Current DBS therapy for ET leaves the device on all of the time, even when you do not have tremor. With R-DBS, the device will only turn on when you make certain movements that lead to tremor.

Continuous DBS can lead to undesirable side effects such as stuttering, walking/balance problems. R-DBS will turn on only in response to a signal in your brain prior to and during tremor, and therefore the DBS will not be on all of the time.

The device actually has the potential to see a brain signal change associated with your tremor less than a second before the tremor occurs. We hope that R-DBS will provide the same benefit with fewer side effects. We believe that R-DBS may also prolong the battery life of your implant.


  • Healthy patients with severe, debilitating intention tremor
  • Healthy patients with recurring intention tremor despite ongoing, optimized VIM DBS therapy


18 to 65



Monetary compensation



Essential tremor, Essential Tremors

Principal Investigator

Karim Oweiss, PhD



Contact Information


352) 273-5566

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