A Phase II Pilot Trial to Estimate Survival After a Non-total Body Irradiation (TBI) Based Conditioning Regimen in Patients Diagnosed With Acute Lymphoblastic Leukemia (ALL) Who Are Pre-allogeneic Hematopoietic Cell Transplantation (HCT) Next-generation-sequence (NGS) Minimal Residual Disease (MRD) Negative
Evaluate the use of non-total body irradiation conditioning for Acute Lymphoblastic Leukemia patients with low risk of relapse as defined by absence of next generation sequencing minimal residual disease before receiving a hematopoietic cell transplant. Patients diagnosed with Acute Lymphoblastic Leukemia who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT.
KeywordsAcute lymphocytic leukemia, acute lymphoblastic leukemia, cancer, total body irradiation
Principal InvestigatorBiljana Horn, M.D.
Sponsoring GroupDepartment of Pediatrics
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