A Phase II Pilot Trial to Estimate Survival After a Non-total Body Irradiation (TBI) Based Conditioning Regimen in Patients Diagnosed With Acute Lymphoblastic Leukemia (ALL) Who Are Pre-allogeneic Hematopoietic Cell Transplantation (HCT) Next-generation-sequence (NGS) Minimal Residual Disease (MRD) Negative

Purpose

Evaluate the use of non-total body irradiation conditioning for Acute Lymphoblastic Leukemia  patients with low risk of relapse as defined by absence of next generation sequencing minimal residual disease before receiving a hematopoietic cell transplant. Patients diagnosed with Acute Lymphoblastic Leukemia  who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT.

Keywords

Acute lymphocytic leukemia, acute lymphoblastic leukemia, cancer, total body irradiation

Principal Investigator

Biljana Horn, M.D.

Sponsoring Group

Department of Pediatrics

Department

Department of Pediatrics

Contact Information

biljana.horn@peds.ufl.edu


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