A Study to Assess the Safety and Effectiveness of FLX-787 in Subjects With Charcot-Marie-Tooth Disease Experiencing Muscle Cramps (COMMIT)


The purpose of this study is to determine how well an investigational product works to prevent, relieve, and reduce muscle cramps in patients with Charcot-Marie-Tooth (CMT) disease. The investigational product is a chemical naturally found in the ginger plant.


  • Approximately 3 clinic visits over 3 months
  • You will be asked to take two study products (one is a treatment that has not been approved as a marketed product and the other is a placebo)
  • Visits will include electrocardiogram (ECG), blood and urine tests 


  • Diagnosis of Charcot-Marie-Tooth disease
  • Cramps 5 or more times per week
  • Normal oral cavity exam

Study Information Flyer


18 to 65
65 and over



Monetary compensation


Can be done from home



Charcot-Marie-Tooth disease, Numbness and tingling, Muscle cramps, Muscle atrophy

Principal Investigator

James Wymer, MD, PhD

Sponsoring Group

Department of Neurology

Contact Information


(352) 294-8948

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