Roland Staud, M.D.

Roland Staud, M.D., F.A.C.P., - Research & Publications

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Publications

Patients With Polymyalgia Rheumatica Had a 2.6-Fold Increased Risk for Vascular Events At a Median 7.8 Years
Annals of Internal Medicine
2015

Patients With Rheumatoid Arthritis and Those With Diabetes Mellitus Had a Similar Increased Risk for Myocardial Infarction
Annals of Internal Medicine
2011

Continuous Descending Modulation of the Spinal Cord Revealed By Functional MRI
PLOS One
2016

Slow Temporal Summation of Pain for Assessment of Central Pain Sensitivity and Clinical Pain of Fibromyalgia Patients
PLOS One
2014

Pain intensity as a moderator of the association between opioid use and insomnia symptoms among adults with chronic pain.
Sleep Medicine
2018

The effects of manipulating the inter-stimulus-interval on heat-evoked temporal summation of second pan across the age span.
Pain
2018

Dynamic Daily Associations Between Insomnia Symptoms and Alcohol Use in Adults With Chronic Pain
Journal of Sleep Research
2018

Optimism and Psychological Resilience are Beneficially associated with Measures of Clinical and Experimental Pain in Adults with or at Risk for Knee Osteoarthritis.
The Clinical journal of pain
2018

Discrepancies in sleep diary and actigraphy assessments in adults with fibromyalgia: Associations with opioid dose and age.
Journal of sleep research
2018

Cerebral blood flow and heart rate variability predict fatigue severity in patients with chronic fatigue syndrome.
Brain Imaging and Behavior
2018

Task Related Cerebral Blood Flow Changes of Patients with Chronic Fatigue Syndrome: An Arterial Spin Labeling Study.
Fatigue : biomedicine, health & behavior
2018

Impact of Moving From a Widespread to Multisite Pain Definition on Other Fibromyalgia Symptoms
Arthritis Care \& Research
2017

Predictors of Osteoarthritis Pain: the Importance of Resilience
Current Rheumatology Reports
2017

Single Nucleotide Polymorphism in the Col11A2 Gene Associated With Heat Pain Sensitivity in Knee Osteoarthritis
Molecular Pain
2017

Increased Spatial Dimensions of Repetitive Heat and Cold Stimuli in Older Women
Pain
2017

Differences in Clinical Pain and Experimental Pain Sensitivity Between Asian Americans and Whites With Knee Osteoarthritis
Clinical Journal of Pain
2017

Biomarkers for Musculoskeletal Pain Conditions: Use of Brain Imaging and Machine Learning
Current Rheumatology Reports
2017

Experimental Pain Phenotyping in Community-Dwelling Individuals With Knee Osteoarthritis
Pain
2016

The Comparative Burden of Chronic Widespread Pain and Fibromyalgia in the United States
Pain Practice
2016

Cognitive-Motivational Influences on Health Behavior Change in Adults With Chronic Pain
Pain Medicine
2016

Abnormal Resting State Functional Connectivity in Patients With Chronic Fatigue Syndrome: An Arterial Spin-Labeling Fmri Study
Magnetic Resonance Imaging
2016

Enhanced Pain Sensitivity Among Individuals With Symptomatic Knee Osteoarthritis: Potential Sex Differences in Central Sensitization
Arthritis Care \& Research
2016

A Cross-Sectional Examination of Vitamin D, Obesity, and Measures of Pain and Function in Middle-Aged and Older Adults With Knee Osteoarthritis
Clinical Journal of Pain
2015

Evidence for Sensitized Fatigue Pathways in Patients With Chronic Fatigue Syndrome
Pain
2015

Placebo Use in Pain Management: the Role of Medical Context, Treatment Efficacy, and Deception in Determining Placebo Acceptability
Pain
2014

Chronic Fatigue Is Associated With Hypoperfusion of Parahippocampal Gyrus.
Arthritis \& Rheumatology
2014

Resting State Functional Connectivity Differs Between Chronic Fatigue Syndrome Patients and Healthy Controls.
Arthritis \& Rheumatology
2014

Cognitive Task Related Hypoperfusion of Frontal Gyrus in Patients With Chronic Fatigue.
Arthritis \& Rheumatology
2014

Pain Hypervigilance Is Associated With Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults With Symptomatic Knee Osteoarthritis
Annals of Behavioral Medicine
2014

Analgesic and Anti-Hyperalgesic Effects of Muscle Injections With Lidocaine Or Saline in Patients With Fibromyalgia Syndrome
European Journal of Pain
2014

Racial and Ethnic Differences in Older Adults With Knee Osteoarthritis
Arthritis \& Rheumatology
2014

Psychological Resilience as a Predictor of Pain and Stress in Symptomatic Knee Osteoarthritis
Psychosomatic Medicine
2014

Psychological Profiles and Pain Characteristics of Older Adults With Knee Osteoarthritis
Arthritis Care \& Research
2013

Perceived Racial Discrimination, But Not Mistrust of Medical Researchers, Predicts the Heat Pain Tolerance of African Americans With Symptomatic Knee Osteoarthritis
Health Psychology
2013

A Population-Based Survey and Physician Assessment of the Characteristics and Prevalence of Fibromyalgia
Arthritis and Rheumatism
2013

Comparative Burden of Chronic Widespread Pain and Fibromyalgia in the Us Population.
Arthritis and Rheumatism
2013

Is the Pain-Reducing Effect of Opioid Medication Reliable? a Psychophysical Study of Morphine and Pentazocine Analgesia
Pain
2013

Temporal Summation of Second Pain: Variability in Responses To a Fixed Protocol
European Journal of Pain
2013

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases
Current Rheumatology Reports
2012

Vitamin D, Race, and Experimental Pain Sensitivity in Older Adults With Knee Osteoarthritis
Arthritis and Rheumatism
2012

How Should We Use the Visual Analogue Scale (Vas) in Rehabilitation Outcomes? Ii: Visual Analogue Scales as Ratio Scales: An Alternative To the View of Kersten Et Al.
Journal of Rehabilitation Medicine
2012

Affect Balance Style, Experimental Pain Sensitivity, and Pain-Related Responses
Clinical Journal of Pain
2012

Abnormal Endogenous Pain Modulation Is a Shared Characteristic of Many Chronic Pain Conditions
Expert Review of Neurotherapeutics
2012

Chronic Pain, Perceived Stress, and Cellular Aging: An Exploratory Study
Molecular Pain
2012

Sleep Predicts Resting Brain Activity in Fibromyalgia Participants With Insomnia
Sleep
2012

Brain Imaging in Fibromyalgia Syndrome
Clinical and Experimental Rheumatology
2011

Attenuation of Experimental Pain By Vibro-Tactile Stimulation in Patients With Chronic Local Or Widespread Musculoskeletal Pain
European Journal of Pain
2011

Sodium Oxybate for the Treatment of Fibromyalgia
Expert Opinion on Pharmacotherapy
2011

Intraindividual Variability in Daily Sleep and Pain Ratings Among Chronic Pain Patients: Bidirectional Association and the Role of Negative Mood
Clinical Journal of Pain
2011

Peripheral Pain Mechanisms in Chronic Widespread Pain
Best Practice \& Research in Clinical Rheumatology
2011

Evaluation of Menstrual Cycle Effects On Morphine and Pentazocine Analgesia
Pain
2011

Two Novel Mutations of Scn9a (Nav1.7) Are Associated With Partial Congenital Insensitivity To Pain
European Journal of Pain
2011

Effectiveness of Cam Therapy: Understanding the Evidence
Rheumatic Disease Clinics of North America
2011

Individual Differences in Morphine and Butorphanol Analgesia: a Laboratory Pain Study
Pain Medicine
2011

The Provisional Diagnostic Criteria for Fibromyalgia: One Step Forward, Two Steps Back: Comment On the Article By Wolfe Et Al
Arthritis Care \& Research
2010

Negative Mood Mediates the Effect of Poor Sleep On Pain Among Chronic Pain Patients
Clinical Journal of Pain
2010

Is it all central sensitization? Role of peripheral tissue nociception in chronic musculoskeletal pain.
Current Rheumatology Reports
2010

Cognitive-affective and somatic side effects of morphine and pentazocine: side-effect profiles in healthy adults.
Pain Medicine
2010

Cognitive-Affective and Somatic Side Effects of Morphine and Pentazocine: Side-Effect Profiles in Healthy Adults
Pain Medicine
2010

Characterization of Sleep Among Older Good Sleepers, Older Adults With Insomnia, and Fibromyalgia Patients With Insomnia
Sleep
2010

Patient-Centered Perspective On Treatment Outcomes in Chronic Pain
Pain Medicine
2010

Mechanisms of Fibromyalgia Pain
CNS Spectrums
2009

Enhanced Central Pain Processing of Fibromyalgia Patients Is Maintained By Muscle Afferent Input: a Randomized, Double-Blind, Placebo-Controlled Study
Pain
2009

Modeling Genetic Imprinting Effects of Dna Sequences With Multilocus Polymorphism Data
Algorithms for Molecular Biology
2009

Abnormal Pain Modulation in Patients With Spatially Distributed Chronic Pain: Fibromyalgia
Rheumatic Disease Clinics of North America
2009

Expansion of the human mu-opioid receptor gene architecture: novel functional variants
Human Molecular Genetics
2009

Patient-Centered Outcome Criteria for Successful Treatment of Facial Pain and Fibromyalgia
Journal of Orofacial Pain
2009

Intra-Individual Variability in Daily Sleep and Pain Ratings Among Chronic Pain Patients
Sleep
2009

Temporal Summation of Heat Pain in Temporomandibular Disorder Patients
Journal of Orofacial Pain
2009

Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia.
Rheumatic Disease Clinics of North America
2009

Chronic widespread pain and fibromyalgia: two sides of the same coin?
Current Rheumatology Reports
2009

Patient-centered outcome criteria for successful treatment of facial pain and fibromyalgia.
Journal of Orofacial Pain
2009

Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data.
Algorithms for Molecular Biology
2009

Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study.
Pain
2009

The overestimation of disease activity in patients with rheumatoid arthritis and concomitant fibromyalgia.
Current Rheumatology Reports
2009

Characteristics of Electronic Visual Analogue and Numerical Scales for Ratings of Experimental Pain in Healthy Subjects and Fibromyalgia Patients
Pain
2008

Genetic Contributions To Pain: a Review of Findings in Humans
Oral Diseases
2008

Brain Activity Associated With Slow Temporal Summation of C-Fiber Evoked Pain in Fibromyalgia Patients and Healthy Controls
European Journal of Pain
2008

Role of Placebo Factors in Clinical Trials With Special Focus On Enrichment Designs
Pain
2008

Cutaneous C-Fiber Pain Abnormalities of Fibromyalgia Patients Are Specifically Related To Temporal Summation
Pain
2008

Importance of Measuring Placebo Factors in Complex Clinical Trials
Pain
2008

Long-Term Trials of Pregabalin and Duloxetine for Fibromyalgia Symptoms: How Study Designs Can Affect Placebo Factors
Pain
2008

A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity
Molecular Pain
2008

A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity
Molecular Pain
2008

Psychophysical and Neurochemical Abnormalities of Pain Processing in Fibromyalgia
CNS Spectrums
2008

Are cannabinoids a new treatment option for pain in patients with fibromyalgia?
Nature Clinical Practice. Rheumatology
2008

A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.
Molecular Pain
2008

The Role of Peripheral Input for Chronic Pain Syndromes Like Fibromyalgia Syndrome
Journal of Musculoskeletal Pain
2008

Autonomic dysfunction in fibromyalgia syndrome: postural orthostatic tachycardia.
Current Rheumatology Reports
2008

Genetic contributions to pain: a review of findings in humans.
Oral Diseases
2008

Psychophysical and neurochemical abnormalities of pain processing in fibromyalgia.
CNS Spectrums
2008

Negative Mood Mediates the Relationship Between Poor Sleep and Increased Pain in Chronic Pain Patients
Sleep
2008

Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls.
European Journal of Pain
2008

Cutaneous C-fiber pain abnormalities of fibromyalgia patients are specifically related to temporal summation.
Pain
2008

Spatial summation of mechanically evoked muscle pain and painful aftersensations in normal subjects and fibromyalgia patients.
Pain
2007

Treatment of fibromyalgia and its symptoms.
Expert Opinion on Pharmacotherapy
2007

Brain activity related to temporal summation of C-fiber evoked pain.
Pain
2007

Mechanisms of acupuncture analgesia: effective therapy for musculoskeletal pain?
Current Rheumatology Reports
2007

Future perspectives: pathogenesis of chronic muscle pain.
Best Practice \& Research in Clinical Rheumatology
2007

Are patients with systemic lupus erythematosus at increased risk for fibromyalgia?
Current Rheumatology Reports
2006

Mechanisms of disease: pain in fibromyalgia syndrome.
Nature Clinical Practice. Rheumatology
2006

Mechanisms of acupuncture analgesia for clinical and experimental pain.
Expert Review of Neurotherapeutics
2006

Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome.
Arthritis Research \& Therapy
2006

Are tender point injections beneficial: the role of tonic nociception in fibromyalgia.
Current Pharmaceutical Design
2006

Predictors of clinical pain intensity in patients with fibromyalgia syndrome.
Current Pain and Headache Reports
2005

Cluster analysis of multiple experimental pain modalities.
Pain
2005

Vitamin D: more than just affecting calcium and bone.
Current Rheumatology Reports
2005

Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine.
Biological Psychology
2005

Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls.
Pain
2005

Predictors of clinical pain intensity in patients with fibromyalgia syndrome.
Current Rheumatology Reports
2004

Fibromyalgia pain: do we know the source?
Current Opinion in Rheumatology
2004

Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects.
Pain
2004

Experimental pain models reveal no sex differences in pentazocine analgesia in humans.
Anesthesiology
2004

Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls.
Pain
2004

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
Proceedings of the National Academy of Sciences
2003

Ratings of experimental pain and pain-related negative affect predict clinical pain in patients with fibromyalgia syndrome.
Pain
2003

Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients.
Pain
2003

Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome.
Pain
2003

Peripheral and central sensitization in fibromyalgia: pathogenetic role.
Current Pain and Headache Reports
2002

Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients.
Pain
2002

Evidence of involvement of central neural mechanisms in generating fibromyalgia pain.
Current Rheumatology Reports
2002

Influenza A-associated bronchiolitis obliterans organizing pneumonia mimicking Wegener's granulomatosis.
Rheumatology international
2001

Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome.
Pain
2001

Evidence for abnormal pain processing in fibromyalgia syndrome.
Pain Medicine
2001

Research Interests

  • Sensory testing in patients with fibromyalgia
  • Double-Blind randomized controlled pilot study of topical ibuprofen gel in osteoarthritis
  • T-cell reactivity in patients with Wegener's Granulomatosis and panartertitis nodosa
  • Anti-neutrophilic cytoplasmic antibodies in patients with cystic fibrosis

Active Research Studies