Siegfried Schmidt, MD

Siegfried O Schmidt, MD, PhD

(352) 265-9475

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Publications

Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening.
Diabetes care
2021

Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype-Derived Activity Scores.
CPT: pharmacometrics & systems pharmacology
2020

Trends in prior receipt of prescription opioid or adjuvant analgesics among patients with incident opioid use disorder or opioid-related overdose from 2006 to 2016.
Drug and alcohol dependence
2019

Trends in prescription opioid use and dose trajectories before opioid use disorder or overdose in US adults from 2006 to 2016: A cross-sectional study.
PLoS medicine
2019

Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene-drug pairs across ambulatory care settings.
Genetics in medicine : official journal of the American College of Medical Genetics
2019

CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics
2019

Clinical application of pharmacogenetics in pain management.
Personalized medicine
2018

Trends in Florida's Prescription Drug Monitoring Program registration and utilization: Implications for increasing voluntary use

2017

Trends in Florida's Prescription Drug Monitoring Program registration and utilization: Implications for increasing voluntary use.
Journal of opioid management
2017

The effect of EHR-integrated patient-reported outcomes on satisfaction with chronic pain care.
The American journal of managed care
2016

Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.
Hypertension (Dallas, Tex. : 1979)
2016

Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to Beta-Blockers in Hypertensive African Americans
Hypertension
2016

Overcoming barriers to implementing patient-reported outcomes in an electronic health record: a case report.
Journal of the American Medical Informatics Association : JAMIA
2016

Toward Clinical Decision Support for Chronic Pain: Integrating Patient Reported Outcomes in An Electronic Health Record
Journal of Pain
2015

Pharmacogenetics: Using Genetic Information to Guide Drug Therapy.
American family physician
2015

PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Journal of hypertension
2015

Clinical pharmacogenetic: What the family physician need to know?

2015

Chronic pain management: pharmacotherapy for chronic pain.
FP essentials
2015

Chronic pain management: legal and licensure issues.
FP essentials
2015

Chronic pain management: evaluation of chronic pain.
FP essentials
2015

Characterizing the Changes in Drug Clearance From Neonates To Adults By Physiologically Based Pharmacokinetic Modeling Using Gastroplus.
Clinical Pharmacology & Therapeutics
2015

Predictors for glucose change in hypertensive participants following short-term treatment with atenolol or hydrochlorothiazide.
Pharmacotherapy
2014

Predictors for Glucose Change in Hypertensive Participants Following Short-term Treatment with Atenolol or Hydrochlorothiazide. Pharmacotherapy

2014

Genome-Wide Association Analysis (Gwas) of Blood Pressure Response To Atenolol-Results From the Pharmacogenomic Evaluation of Antihypertensive Responses (Pear) Study
Clinical Pharmacology & Therapeutics
2014

Characteristics of sensitization associated with chronic pain conditions.
The Clinical journal of pain
2014

A Cyp2C19 Genotype Guided Dosing Approach for Optimizing Voriconazole in Patients With Ifis.
Pharmacotherapy
2014

Systems approaches in risk assessment.
Clinical pharmacology and therapeutics
2013

Peripheral neuropathy linked to obstructive sleep apnea?
The Journal of family practice
2013

Peripheral neuropathy linked to obstructive sleep apnea? OSA may not be the first thing that comes to mind when examining a patient with peripheral neuropathy, but treating the sleep disorder can produce surprising benefits
Journal of Family Practice
2013

Antihypertensive Medication Exposure and Adverse Glycemic Effects: An Evaluation of Fasting and Stimulated Glucose
Clinical Pharmacology & Therapeutics
2012

Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation, and Sensitivity to Thermal Cutaneous Stimulation.
Pain research and treatment
2010

Extreme thermal sensitivity and pain-induced sensitization in a fibromyalgia patient.
Pain research and treatment
2010

Atenolol exposure and risk for development of adverse metabolic effects: a pilot study.
Pharmacotherapy
2010

Hydrochlorothiazide and atenolol combination antihypertensive therapy: effects of drug initiation order.
Clinical pharmacology and therapeutics
2009

Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome.
Pain
2005

Evaluation of a quality improvement intervention for diabetes management.
Journal for healthcare quality : official publication of the National Association for Healthcare Quality
2003

Research Interests

Ongoing Research Support
Co-Investigator for “Pharmacokinetic and Pharmacodynamic (PK-PD) Studies of Cardiovascular Drugs” (Source: 1U01FD005235-01) PIs: L.Cavallari and J.Johnson. PK-PD study is sponsored by the Food and Drug Administration (FDA) for a total award $ 2,332,870. University of Florida, Gainesville, Florida, September 1, 2014 through August 31, 2017
PI for “Establishing a Pain Management Program within a University based Family Medicine Residency.” (IRB Project 2014 01037), University of Florida, Gainesville, Florida, May 22, 2015 through May 22, 2020.
Completed Support
Sub-Investigator for “Implementing Genomics in Practice (IGNITE) Proof of Concept Study: Genotyping in Family Medicine Clinics.” PIs: L. Cavallari, PharmD, and J Johnson, PharmD, Genomic Medicine Implementation: The Personalized Medicine Program, University of Florida Health. University of Florida, Gainesville, Florida, March 4, 2015- September 1, 2016.
Co-Investigator for “An Integrative and Sustainable Approach to Pain Management in Primary Care” (UF Project #108663, UF Contract #89684. Sponsored by a Pfizer. 07/01/2013 thru 06/30/2015
Sub-Investigator for “Pharmacogenomic Evaluation of Antihypertensive Responses II (PEAR) grant project;
Julie A. Johnson PharmD, Principal Investigator. The PEAR grant is sponsored by the National Institutes of Health for a total award $ 2,064,000. University of Florida, Gainesville, Florida, 2010 – 2013.

Sub-Investigator for “Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study (#237-2009). PEAR Extension Study project. Julie A. Johnson PharmD, Principle Investigator, Supervisory Chair of Graduate Committee, Rhonda Cooper-DeHoff PharmD, Co-Principle Investigator, Graduate Committee Member, Mariellen J. Moore PharmD, Sub-Investigator, Graduate Student, Whit Curry MD, Sub-Investigator, Kendall Campbell MD, Sub-Investigator, John Gums PharmD, Sub-Investigator. The PEAR grant is sponsored by the National Institutes of Health. University of Florida, Gainesville, Florida, 2009 – 2012.

Sub-Investigator for “Atenolol exposure as risk for adverse metabolic responses to beta blockers”. PEAR extension study project; Julie A. Johnson PharmD, Principal Investigator. The PEAR grant is sponsored by the National Institutes of Health for a total award $205,992University of Florida, Gainesville, Florida, 2007 – 2012.
Sub-Investigator for “Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) grant project;
Julie A. Johnson PharmD, Principal Investigator. The PEAR grant is sponsored by the National Institutes of Health for a total award $ 205,992. University of Florida, Gainesville, Florida, 2005 – 2010.

Sub-Investigator for “Characteristics of Central Pain Sensitization in Chronic Pain Diseases Following Analgesic Intervention,” Principle Investigator A.P. Mauderli, University of Florida, Gainesville, Florida, 2005 – 2012.
Sub-Investigator for “Spatial and Temporal Characteristics of Central Pain Sensitization in Chronic Pain Diseases,” Principle Investigator A.P. Mauderli, funded by the BSCIRTF Research Program of the McKnight Brain Institute, University of Florida, Gainesville, Florida, 2005 – 2010.

“Helping Educators Address the Development of Appropriate Curriculum for Headache Education (HEADACHE) Project.” Curriculum Committee Member and Consulting Faculty. The HEADACHE project is sponsored by the National Headache Foundation (NHF), in cooperation with the Society of Teachers of Family Medicine (STFM), 2003 – 2006.

Sub-Investigator for “Central Pain Sensitization in Irritable Bowel Syndrome.” Principle investigators: G.N. Verne and A.P. Mauderli, sponsored by National Institute of Health HINDS and Research Service of the Veterans Administration, Gainesville, Florida, 2003 – 2004.

Principle Investigator for “Ongoing Effectiveness of a Diabetes Flow Sheet in Improving Diabetes Care in Family Practice,” Protocal 33-2003, University of Florida, Gainesville, Florida, 2003 – 2004.

Sub-Investigator for “Residency Training in Primary Care Grant,” To better teach residents end-of-life care. Principle investigator: K Hall, sponsored by HRSA, 2002 – 2005.

Sub-Investigator for “The Effect of Mild Traumatic Brain Injury on Pain Perception in Human,” Protocol 465-2002. Principle Investigator A.P. Mauderli, funded by the BSCIRTF Research Program of the McKnight Brain Institute, University of Florida, Gainesville, Florida, 2002 – 2006.

Sub-Investigator for the INVEST Sub-study, “Heart Disease Outcomes: Impact of Genetics and Pharmacogenetics,” Protocol 661-00. Principal Investigator C.J. Pepine, University of Florida, Gainesville, Florida, 2002 – 2005.

Co-Investigator for the National Institutes of Health grant “Spatial and Temporal Characteristics of Central Pain Sensitization in Chronic Pain Diseases,” Principle Investigator A. P. Mauderli; University of Florida, Gainesville, Florida, 2002 – 2012.

“ASTHMA COLLABORATIVE,” a Learning and Improvement Collaborative on Healthcare for Children with Asthma. This was a quality improvement project developed and facilitated by the National Initiative for Children’s Healthcare Quality (NICHQ), and was sponsored by AAFP (American Academy of Family Physicians) as part of their Quality Initiative. Participated as a team member, Quality Care Committee, Department of Community Health and Family Medicine, University of Florida, Gainesville, Florida, 2002 – 2003.

Co-Project Director for the HRSA grant, “Establishment of Departments of Family Medicine, 93,984”, “Family Medicine Quality Improvement Initiative” at the University of Florida, Gainesville, Florida. Fund amount: $250,526, 1999 – 2002.

Sub- Investigator for Invest Study (International Verapamil SR-Trandolapril Study), University of Florida, College of Medicine, Gainesville, Florida, 1997 – 2003.