Steven Hughes, MD

Steven J Hughes, MD

(352) 265-0535

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Publications

Unique circulating immune signatures for recurrent acute pancreatitis, chronic pancreatitis and pancreatic cancer: A pilot study of these conditions with and without diabetes.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
2020

The use of pancreatic enzyme replacement therapy in patients with a diagnosis of chronic pancreatitis and pancreatic cancer in the US is infrequent and inconsistent.
Alimentary pharmacology & therapeutics
2020

The Fistula Risk Score Catalog: Toward Precision Medicine for Pancreatic Fistula After Pancreatoduodenectomy.
Annals of surgery
2020

Relapsing Acute Pancreatitis Caused by a Mucinous Cystic Neoplasm.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2020

Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons
2020

Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers
2020

Impact of hospital volume on patient safety indicators and failure to rescue following open aortic aneurysm repair.
Journal of vascular surgery
2020

From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
Cytokine & growth factor reviews
2020

Thermal ablation versus wedge or segmental resection in patients with early stage hepatocellular carcinoma: a population survival analysis.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2019

The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.
Proteomics
2019

Pitfalls of minimally invasive pancreatoduodenectomy.
Annals of pancreatic cancer
2019

Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Acta biomaterialia
2018

Stroma-derived extracellular vesicles deliver tumor-suppressive miRNAs to pancreatic cancer cells.
Oncotarget
2018

Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas
2018

Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for stage II and III disease.
Cancer
2018

Readmission After Elective Ileostomy in Colorectal Surgery Is Predictable.
JSLS : Journal of the Society of Laparoendoscopic Surgeons
2018

Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy.
Journal of the National Cancer Institute
2018

Pancreatogastrostomy Vs. Pancreatojejunostomy: a Risk-Stratified Analysis of 5316 Pancreatoduodenectomies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2018

PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies: Rationale and Study Design for PROCEED From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas
2018

Objective Preoperative Parameters Predict Difficult Pelvic Dissections and Clinical Outcomes.
The Journal of surgical research
2018

Non-surgical management of patients with intrahepatic cholangiocarcinoma in the United States, 2004-2015: an NCDB analysis.
Journal of gastrointestinal oncology
2018

Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences
2018

Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis
2018

Clinical Factors as a Component of the Personalized Treatment Approach to Advanced Pancreatic Cancer: a Systematic Literature Review.
Journal of gastrointestinal cancer
2018

Characterization and Optimal Management of High-risk Pancreatic Anastomoses During Pancreatoduodenectomy.
Annals of surgery
2018

Break Scrub to Take That Phone Call?
Journal of the American College of Surgeons
2018

A Prospective Study to Establish a New-Onset Diabetes Cohort: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas
2018

The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Oncotarget
2017

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Pancreas
2017

Minimally invasive pancreatoduodenectomy.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2017

Incorporation of Procedure-specific Risk Into the ACS-NSQIP Surgical Risk Calculator Improves the Prediction of Morbidity and Mortality After Pancreatoduodenectomy.
Annals of surgery
2017

Improvement in Resident Robotic Surgical Perception with a Cadaver Training Lab: A Pilot Study.
The American surgeon
2017

Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery
2017

Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget
2017

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research
2017

Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer.
World journal of gastrointestinal surgery
2017

Eosinophilic Pancreatitis: A Rare Cause of Recurrent Acute Pancreatitis.
Case reports in gastroenterology
2017

Cost Effectiveness of a Novel Attempt to Reduce Readmission after Ileostomy Creation.
JSLS : Journal of the Society of Laparoendoscopic Surgeons
2017

Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2017

A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery
2017

A Prospective Randomized Multicenter Trial of Distal Pancreatectomy With and Without Routine Intraperitoneal Drainage.
Annals of surgery
2017

The Characterization and Prediction of ISGPF Grade C Fistulas Following Pancreatoduodenectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2016

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?
Pharmacology & therapeutics
2016

Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer.
American journal of surgery
2016

Risk-adjusted Outcomes of Clinically Relevant Pancreatic Fistula Following Pancreatoduodenectomy: A Model for Performance Evaluation.
Annals of surgery
2016

Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2016

Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research
2016

Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.
The American journal of pathology
2016

EGFR family and cMet expression profiles and prognostic significance in esophagogastric adenocarcinoma.
Journal of gastrointestinal oncology
2016

Discordant HER2 expression and response to neoadjuvant chemoradiotherapy in esophagogastric adenocarcinoma.
Journal of gastrointestinal oncology
2016

The value of drains as a fistula mitigation strategy for pancreatoduodenectomy: something for everyone? Results of a randomized prospective multi-institutional study.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2015

The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival.
BMC cancer
2015

Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology
2015

Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements.
The American journal of pathology
2015

Multidisciplinary neoadjuvant management for potentially curable pancreatic cancer.
Cancer medicine
2015

Local pancreatic head resection: the search for optimal indications through quality of life assessments.
American journal of surgery
2015

Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII
2015

An unusual case of colonic hemorrhage.
Gastroenterology
2015

c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer.
World journal of gastroenterology
2014

The impact of interhospital transfers on surgical quality metrics for academic medical centers.
The American surgeon
2014

Photoacoustic and fluorescence image-guided surgery using a multifunctional targeted nanoprobe.
Annals of surgical oncology
2014

Laparoscopic intussuscepting pancreaticojejunostomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2014

IgG4-related cholecystitis presenting as biliary malignancy: report of three cases.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2014

Esophageal perforation management using a multidisciplinary minimally invasive treatment algorithm.
Journal of the American College of Surgeons
2014

Disconnected pancreatic duct syndrome: disease classification and management strategies.
Journal of the American College of Surgeons
2014

A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage.
Annals of surgery
2014

Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique.
Annals of surgery
2013

Failure to follow evidence-based best practice guidelines in the treatment of severe acute pancreatitis.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2013

Comparative effectiveness of minimally invasive and open distal pancreatectomy for ductal adenocarcinoma.
JAMA surgery
2013

Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.
PloS one
2013

Abdominal compartment syndrome is an early, lethal complication of acute pancreatitis.
The American surgeon
2013

Port-site recurrence of pancreatic adenocarcinoma following laparoscopic pancreaticoduodenectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2012

Outcomes of operative management of appendicitis.
Surgical infections
2012

Minimally invasive treatment of pancreatic disease.
Current gastroenterology reports
2012

Faculty clinical quality goals drive improvement in University HealthSystem Consortium outcome measures.
The American surgeon
2012

Phase II study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancer.
Annals of surgical oncology
2011

Delayed operating room availability significantly impacts the total hospital costs of an urgent surgical procedure.
Surgery
2011

Cytoplasmic overexpression of CD95L in esophageal adenocarcinoma cells overcomes resistance to CD95-mediated apoptosis.
Neoplasia (New York, N.Y.)
2011

Can laparoscopic pancreaticoduodenectomy be safely implemented?
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2011

Bile salts differentially sensitize esophageal squamous cells to CD95 (Fas/Apo-1 receptor) mediated apoptosis.
The Journal of surgical research
2011

Short- and long-term costs of laparoscopic colectomy are significantly less than open colectomy.
Surgical endoscopy
2010

Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.
Blood
2010

Validation of a prediction rule to maximize curative (R0) resection of early-stage pancreatic adenocarcinoma.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2009

Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR.
Annals of surgical oncology
2009

Minimal-access technique for distal catheter insertion during ventricular peritoneal shunt procedures: a review of 100 cases.
Journal of neurosurgery
2009

Inhibition of HGF/MET as therapy for malignancy.
Expert opinion on therapeutic targets
2009

A quantitative reverse transcription-PCR assay for rapid, automated analysis of breast cancer sentinel lymph nodes.
The Journal of molecular diagnostics : JMD
2009

The Color Object Association Test (COAT): the development of a new measure of declarative memory for 18- to 36-month-old toddlers.
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
2008

Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2008

Update for surgeons: recent and noteworthy changes in therapeutic regimens for cancer of the colon and rectum.
Journal of the American College of Surgeons
2007

Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers.
Clinical chemistry
2007

Necrotizing pancreatitis.
Gastroenterology clinics of North America
2007

Minimally invasive treatment of pancreatic disease.
Gastroenterology clinics of North America
2007

Laparoscopic colorectal surgery is safe in the high-risk patient: a NSQIP risk-adjusted analysis.
Surgery
2007

Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature.
The Journal of molecular diagnostics : JMD
2007

Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence.
Journal of surgical education
2007

Clinical challenges and images in GI. Endometriosis of the sigmoid colon with endometriotic features within mesenteric lymph nodes.
Gastroenterology
2007

Laparoscopic repair of umbilical hernias in conjunction with other laparoscopic procedures.
JSLS : Journal of the Society of Laparoendoscopic Surgeons
2006

Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.
Neoplasia (New York, N.Y.)
2006

Image of the month.
Gastroenterology
2006

Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer.
Clinical chemistry
2006

Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma.
Neoplasia (New York, N.Y.)
2006

A rapid, fully automated, molecular-based assay accurately analyzes sentinel lymph nodes for the presence of metastatic breast cancer.
Annals of surgery
2006

The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma.
Neoplasia (New York, N.Y.)
2005

Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testing.
Clinical chemistry
2005

Student attendance during college-based lectures: a pilot study.
Nursing standard (Royal College of Nursing (Great Britain) : 1987)
2005

Molecular staging of lymph nodes from patients with esophageal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
2005

IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
2005

Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma.
The Journal of surgical research
2005

Fondaparinux requires further study before firm recommendation.
Archives of internal medicine
2003

Enoxaparin or fondaparinux for thrombosis prevention after orthopaedic surgery.
Lancet (London, England)
2002

Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas.
British journal of cancer
1999

Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia.
Neoplasia (New York, N.Y.)
1999

Lack of cell surface Fas/APO-1 expression in pulmonary adenocarcinomas.
The Journal of clinical investigation
1998

Impaired glucose-stimulated insulin release in islets from adult rats malnourished during foetal-neonatal life.
Molecular and cellular endocrinology
1998

A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America
1998

The effect of maternal protein deficiency during pregnancy and lactation on glucose tolerance and pancreatic islet function in adult rat offspring.
The Journal of endocrinology
1997

Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.
Cancer research
1997

Impaired glucose tolerance and mild hyperglycemia in sucrose-fed rats does not impair insulin secretion.
Acta diabetologica
1996

Chronic bile diversion does not alter canine interdigestive myoelectric activity.
Digestive diseases and sciences
1993

Research Interests

Dr. Hughes' research interests center on improving the understanding of gastrointestinal tumor biology through genetic analysis and assessing the response of these historically stubborn tumors to a new class of medications called tyrosine kinase inhibitors.