Steven Hughes, M.D.

Steven J Hughes, M.D. - Research & Publications

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Publications

Thermal ablation versus wedge or segmental resection in patients with early stage hepatocellular carcinoma: a population survival analysis.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2018

Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for stage II and III disease.
Cancer
2018

Pancreatogastrostomy Vs. Pancreatojejunostomy: a Risk-Stratified Analysis of 5316 Pancreatoduodenectomies
Journal of Gastrointestinal Surgery
2018

PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies: Rationale and Study Design for PROCEED From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas
2018

Non-Surgical Management of Patients With Intrahepatic Cholangiocarcinoma in the United States, 2004-2015: An Ncdb Analysis

2018

Intestinal Microbiota Enhances Pancreatic Carcinogenesis in Preclinical Models
Carcinogenesis
2018

Characterization and Optimal Management of High-Risk Pancreatic Anastomoses During Pancreatoduodenectomy

2018

Break Scrub to Take That Phone Call?
Journal of the American College of Surgeons
2018

The Pancreatic Tumor Microenvironment Drives Changes in Mirna Expression That Promote Cytokine Production and Inhibit Migration By the Tumor Associated Stroma
Oncotarget
2017

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease
Pancreas
2017

Human Pancreatic Cancer Cells Induce a Myd88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment
Cancer Research
2017

Feasibility of Pancreatectomy Following High-Dose Proton Therapy for Unresectable Pancreatic Cancer
World Journal of Gastrointestinal Surgery
2017

Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy
Journal of Gastrointestinal Surgery
2017

A Clinically Applicable Muscular Index Predicts Long-Term Survival in Resectable Pancreatic Cancer
Surgery
2017

The Characterization and Prediction of Isgpf Grade C Fistulas Following Pancreatoduodenectomy
Journal of Gastrointestinal Surgery
2016

Standardization of Surgical Care in a High-Volume Center Improves Survival in Resected Pancreatic Head Cancer
American Journal of Surgery
2016

Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies
Journal of Gastrointestinal Surgery
2016

Isolation of Pancreatic Cancer Cells From a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture
American Journal of Pathology
2016

The Value of Drains as a Fistula Mitigation Strategy for Pancreatoduodenectomy: Something for Everyone? Results of a Randomized Prospective Multi-Institutional Study
Journal of Gastrointestinal Surgery
2015

The Inflammatory Milieu Within the Pancreatic Cancer Microenvironment Correlates With Clinicopathologic Parameters, Chemoresistance and Survival
Bmc Cancer
2015

Patient-Derived Xenograft Models for Pancreatic Adenocarcinoma Demonstrate Retention of Tumor Morphology Through Incorporation of Murine Stromal Elements
American Journal of Pathology
2015

Local Pancreatic Head Resection: the Search for Optimal Indications Through Quality of Life Assessments
American Journal of Surgery
2015

c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer
World Journal of Gastroenterology
2014

The Impact of Interhospital Transfers On Surgical Quality Metrics for Academic Medical Centers
The American Surgeon
2014

Photoacoustic and Fluorescence Image-Guided Surgery Using a Multifunctional Targeted Nanoprobe
Annals of Surgical Oncology
2014

Laparoscopic Intussuscepting Pancreaticojejunostomy
Journal of Gastrointestinal Surgery
2014

Igg4-Related Cholecystitis Presenting as Biliary Malignancy: Report of Three Cases
Journal of Gastrointestinal Surgery
2014

Disconnected Pancreatic Duct Syndrome: Disease Classification and Management Strategies
Journal of the American College of Surgeons
2014

A Randomized Prospective Multicenter Trial of Pancreaticoduodenectomy With and Without Routine Intraperitoneal Drainage
Annals of Surgery
2014

Robot-Assisted Minimally Invasive Distal Pancreatectomy Is Superior To the Laparoscopic Technique
Annals of Surgery
2013

Failure To Follow Evidence-Based Best Practice Guidelines in the Treatment of Severe Acute Pancreatitis
Hpb
2013

Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma
PLOS One
2013

Port-Site Recurrence of Pancreatic Adenocarcinoma Following Laparoscopic Pancreaticoduodenectomy
Journal of Gastrointestinal Surgery
2012

Outcomes of Operative Management of Appendicitis
Surgical Infections
2012

Minimally invasive treatment of pancreatic disease
Current Gastroenterology Reports
2012

Can Laparoscopic Pancreaticoduodenectomy Be Safely Implemented?
Journal of Gastrointestinal Surgery
2011

Research Interests

Dr. Hughes' research interests center on improving the understanding of gastrointestinal tumor biology through genetic analysis and assessing the response of these historically stubborn tumors to a new class of medications called tyrosine kinase inhibitors.