Steven Roper, M.D.

Steven N Roper, M.D.

(352) 273-6990

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Publications

Inflammatory myofibroblastic tumor masquerading as an anterior choroidal artery fusiform aneurysm.
Surgical neurology international
2021

Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.
Neurology
2020

Comparing Standard Performance and Outcome Measures in Hospitalized Pituitary Tumor Patients with Secretory versus Nonsecretory Tumors.
World neurosurgery
2020

Two Groups of eGFP-Expressing Neurons with Distinct Characteristics in the Neocortex of GIN Mice.
Neuroscience
2019

The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences.
Surgical and radiologic anatomy : SRA
2017

Long-term Outcome After Fractionated Radiotherapy for Pituitary Adenoma: The Curse of the Secretory Tumor.
American journal of clinical oncology
2016

Genetic animal models of malformations of cortical development and epilepsy.
Journal of neuroscience methods
2016

Early Life Seizures and Learning Impairment: Neither the Time nor the Place.
EBioMedicine
2016

Functional integration of human neural precursor cells in mouse cortex.
PloS one
2015

Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.
PloS one
2015

TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia.
Journal of neurophysiology
2014

Reduced chemical and electrical connections of fast-spiking interneurons in experimental cortical dysplasia.
Journal of neurophysiology
2014

In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies.
Epilepsia
2014

Stem cells as a potential therapy for epilepsy.
Experimental neurology
2013

Reduced densities of parvalbumin- and somatostatin-expressing interneurons in experimental cortical dysplasia and heterotopia in early postnatal development.
Epilepsy research
2013

Cavernoma-related epilepsy: review and recommendations for management--report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies.
Epilepsia
2013

Assessing the driving performance of a person with epilepsy presurgery and postsurgery.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association
2013

Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.
Brain research
2012

Microglial-Neuronal Interactions in the Paraventricular Nucleus (Pvn): a Potential Mechanism Underlying Neurogenic Hypertension
The FASEB's Journal
2012

Impaired hippocampal memory function and synaptic plasticity in experimental cortical dysplasia.
Epilepsia
2012

Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice.
PloS one
2012

The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission.
Epilepsia
2011

Do subtle cortical structure changes indicate a developmental basis for temporal lobe epilepsy?
Neurology
2011

Common data elements in epilepsy research: development and implementation of the NINDS epilepsy CDE project.
Epilepsia
2011

Atypical Rasmussen's encephalitis treated with temporal lobectomy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2011

Altered firing rates and patterns in interneurons in experimental cortical dysplasia.
Cerebral cortex (New York, N.Y. : 1991)
2011

Altered behavior in experimental cortical dysplasia.
Epilepsia
2011

Disrupting abnormal electrical activity with deep brain stimulation: is epilepsy the next frontier?
Neurosurgical focus
2010

Densities of glutamatergic and GABAergic presynaptic terminals are altered in experimental cortical dysplasia.
Epilepsia
2010

Surgical treatment of the extratemporal epilepsies.
Epilepsia
2009

Seizure recurrence following epilepsy surgery: is post-operative EEG helpful?
Seizure
2009

Long-term potentiation of excitatory synapses on neocortical somatostatin-expressing interneurons.
Journal of neurophysiology
2009

How Important Is Invasive Ictal Recording in Patients With Itractable Tle and Normal Mri?
Epilepsia
2009

Developmental Expression of Parvulbumin and Somatostatin in Gabaergic Interneurons in Normal Rodent Cortex and Experimental Cortical Dysplasia
Epilepsia
2009

Basic mechanisms of MCD in animal models.
Epileptic disorders : international epilepsy journal with videotape
2009

Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia.
Journal of neurophysiology
2009

Adult Human Neural Progenitor Cells Survive, Migrate, and Differentiate Into Multiple Neuronal Phenotypes in Experimental Cortical Dysplasia
Epilepsia
2009

Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.
Physics in medicine and biology
2008

Enhanced Synaptic Activity in Cortical Interneurons in a Mouse Model of Cortical Dysplasia
Epilepsia
2008

Analysis of Epileptiform Activity From Acute Cortical Slice On a 3D 60 Channel Microelectrode Array in Irradiated Rats
Epilepsia
2008

4-Aminopyridine Produces Increased Excitability But Decreased Time-Dependent Variability in Excitatory Synaptic Activity in the Neocortex
Epilepsia
2008

Impaired developmental switch of short-term plasticity in pyramidal cells of dysplastic cortex.
Epilepsia
2007

Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
2006

Superior divisional third cranial nerve paresis: clinical and anatomical observations of 2 unique cases.
Archives of neurology
2006

Reduced excitatory drive in interneurons in an animal model of cortical dysplasia.
Journal of neurophysiology
2006

Episodic memory in patients with focal frontal lobe lesions.
Cortex; a journal devoted to the study of the nervous system and behavior
2006

Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain.
Development (Cambridge, England)
2006

A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit.
Journal of neuroscience methods
2006

Semantic priming in patients with right frontal lobe lesions.
Journal of the International Neuropsychological Society : JINS
2005

Phenotypic and functional characterization of adult brain neuropoiesis.
Proceedings of the National Academy of Sciences of the United States of America
2005

Neuron-to-astrocyte transition: phenotypic fluidity and the formation of hybrid asterons in differentiating neurospheres.
The Journal of comparative neurology
2005

Attentional inhibition in patients with focal frontal lobe lesions.
Journal of clinical and experimental neuropsychology
2005

Tonic activity of metabotropic glutamate receptors is involved in developmental modification of short-term plasticity in the neocortex.
Journal of neurophysiology
2004

The GABAergic system of the developing neocortex has a reduced capacity to recover from in utero injury in experimental cortical dysplasia.
Journal of neuropathology and experimental neurology
2004

Effectiveness of vagus nerve stimulation in epilepsy patients: a 12-year observation.
Neurology
2004

Cortical dysplasia and epilepsy: animal models.
Advances in experimental medicine and biology
2004

Water diffusion measurements in perfused human hippocampal slices undergoing tonicity changes.
Magnetic resonance in medicine
2003

Reduction of spontaneous inhibitory synaptic activity in experimental heterotopic gray matter.
Journal of neurophysiology
2003

PKA and PKC enhance excitatory synaptic transmission in human dentate gyrus.
Journal of neurophysiology
2003

Cannabinoid receptor-1 activation suppresses inhibitory synaptic activity in human dentate gyrus.
Neuropharmacology
2003

Altered corticogenesis and neuronal morphology in irradiation-induced cortical dysplasia: a Golgi-Cox study.
Journal of neuropathology and experimental neurology
2003

MMPI-2 profiles of patients with intractable epilepsy.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
2002

Cortical dysgenesis and epilepsy.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
2002

Category-specific naming deficits for objects and actions: semantic attribute and grammatical role hypotheses.
Neuropsychologia
2002

The role of the frontal lobes in memory: evidence from unilateral frontal resections for relief of intractable epilepsy.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
2001

Lateralization of temporal lobe foci: depth versus subdural electrodes.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2001

Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus.
Annals of neurology
2001

An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability.
The European journal of neuroscience
2001

Reduced inhibition in an animal model of cortical dysplasia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
2000

Electroencephalographic, volumetric, and neuropsychological indicators of seizure focus lateralization in temporal lobe epilepsy.
Archives of neurology
2000

Bcl-2 immunoreactive cells with immature neuronal phenotype exist in the nonepileptic adult human brain.
Journal of neuropathology and experimental neurology
2000

Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy.
The Journal of comparative neurology
2000

Synaptic responses of neurons in heterotopic gray matter in an animal model of cortical dysgenesis.
Developmental neuroscience
1999

Reduced density of parvalbumin- and calbindin D28-immunoreactive neurons in experimental cortical dysplasia.
Epilepsy research
1999

Electrophysiological responses in vivo of hippocampal CA1 pyramidal neurons in an animal model of neuronal migration disorders.
Developmental neuroscience
1999

Conduction aphasia and the arcuate fasciculus: A reexamination of the Wernicke-Geschwind model.
Brain and language
1999

Tuberous sclerosis-related gene expression in normal and dysplastic brain.
Epilepsy research
1998

In vivo detection of experimentally induced cortical dysgenesis in the adult rat neocortex using optical coherence tomography.
Journal of neuroscience methods
1998

In utero irradiation of rats as a model of human cerebrocortical dysgenesis: a review.
Epilepsy research
1998

White matter neuronal heterotopia in temporal lobe epilepsy: a morphometric and immunohistochemical study.
Journal of neuropathology and experimental neurology
1997

Non-linearity in invasive EEG recordings from patients with temporal lobe epilepsy.
Electroencephalography and clinical neurophysiology
1997

Invasive monitoring of limbic epilepsy using stereotactic depth and subdural strip electrodes: surgical technique.
Surgical neurology
1997

Exposure to in utero irradiation produces disruption of radial glia in rats.
Developmental neuroscience
1997

Disinhibited in vitro neocortical slices containing experimentally induced cortical dysplasia demonstrate hyperexcitability.
Epilepsy research
1997

The taste of monosodium glutamate: membrane receptors in taste buds.
The Journal of neuroscience : the official journal of the Society for Neuroscience
1996

Quantified volumes of temporal lobe structures in patients with epilepsy.
Journal of neuroimaging : official journal of the American Society of Neuroimaging
1996

Prospective localization of epileptogenic foci: comparison of PET and SPECT with site of surgery and clinical outcome.
Radiology
1996

Intractable temporal lobe epilepsy: comparison of positron emission tomography with qualitative and quantitative MR.
AJNR. American journal of neuroradiology
1996

Hippocampal volumetrics differentiate patients with temporal lobe epilepsy and extratemporal lobe epilepsy.
Archives of neurology
1995

Experimentally induced disorders of neuronal migration produce an increased propensity for electrographic seizures in rats.
Epilepsy research
1995

Ca(2+)-dependent Cl- conductance in taste cells from Necturus.
Journal of neurophysiology
1994

Surgical treatment of partial epilepsy arising from the insular cortex. Report of two cases.
Journal of neurosurgery
1993

Surgical anatomy of the temporal lobe.
Neurosurgery clinics of North America
1993

Surgery for epilepsy. Special pediatric considerations.
Neurosurgery clinics of North America
1993

Increased propensity for nonsynaptic epileptiform activity in immature rat hippocampus and dentate gyrus.
Journal of neurophysiology
1993

Osmolality and nonsynaptic epileptiform bursts in rat CA1 and dentate gyrus.
Annals of neurology
1992

An analysis of cerebral blood flow in acute closed-head injury using technetium-99m-HMPAO SPECT and computed tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
1991

Retrograde effects of target atrophy on submandibular ganglion neurons.
Journal of neurophysiology
1987

Neonatal synapse elimination in the rat submandibular ganglion: effect of retarded target growth.
Journal of neurophysiology
1987

On the two subdivisions and intrinsic synaptic connexions in the submandibular ganglion of the rat.
The Journal of physiology
1984

Reinnervation of the amphibian cardiac ganglion after complete or partial denervation.
The Journal of physiology
1982

Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization.
Science (New York, N.Y.)
1978

Synaptic organization and acetylcholine sensitivity of multiply innervated autonomic ganglion cells.
Cold Spring Harbor symposia on quantitative biology
1976

An electrophysiological study of chemical and electrical synapses on neurones in the parasympathetic cardiac ganglion of the mudpuppy, Necturus maculosus: evidence for intrinsic ganglionic innervation.
The Journal of physiology
1976

Research Interests

Grants - Intramural:

  • "Reactive Synaptogenesis and Synaptic Plasticity in Human Dentate Gyrus"
  • "Reactive Synaptogenesis and Novel Forms of Synaptic Transmission and Long-Term Potentiation in the Dentate Gyrus"
  • "Implantation of Adult Human Neural Progenitors into an Animal Model of Cortical Dysplasia"