W. Stratford May, M.D.

W. Stratford May, Jr., M.D., Ph.D. - Research & Publications

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Publications

Poor Peripheral Blood Stem Cell Mobilization Correlates With Worse Long-Term Outcomes in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

2015

Pkr Inhibits the DNa Damage Response, and Is Associated With Poor Survival in Aml and Accelerated Leukemia in Nhd13 Mice
Blood
2015

Trim29 Suppresses Twist1 and Invasive Breast Cancer Behavior
Cancer Research
2014

Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product
Neoplasia (Basingstoke. Online)
2014

Pkr Cooperates With An Mds Driver Mutation To Worsen Cytopenias and Promote Acute Leukemia
Cancer Research
2014

Pkr Negatively Regulates Leukemia Progression in Association With Pp2a Activation, Bcl-2 Inhibition and Increased Apoptosis
Blood Cancer Journal
2013

The Rax/Pact-Pkr Stress Response Pathway Promotes P53 Sumoylation and Activation Leading To G(1) Arrest
Cell Cycle
2012

Increased Expression of the Dsrna-Activated Protein Kinase Pkr in Breast Cancer Promotes Sensitivity To Doxorubicin
PLOS One
2012

Jaz Mediates G(1) Cell Cycle Arrest By Interacting With and Inhibiting E2F1
Cell Cycle
2011

Tnk1/Kos1: a novel tumor suppressor.
Transactions of the American Clinical and Climatological Association
2010

Aberrant Ras Activation Associated With Functional Loss of Tnk1/Kos1 in Human B-Cell Lymphoma
Blood
2010

Protein Phosphatase 2a Inactivates Bcl2's Antiapoptotic Function By Dephosphorylation and Up-Regulation of Bcl2-P53 Binding
Blood
2009

Loss of Tnk1/Kos1 in Mice Is Associated With B-Lymphomas Specifically Dlbcl
Blood
2009

Functional Characterization of the Murine Tnk1 Promoter
Gene
2009

Expression of Jaz in Multiple Myeloma and Its Potential Role as a Novel Molecular Target
Blood
2009

A Novel Role for Uric Acid in Acute Kidney Injury Associated With Tumour Lysis Syndrome
Nephrology Dialysis Transplantation
2009

Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors
Cancer Research
2008

Structure-Based Jaz Ligand-Ji and Its Analogues Show Strong Cytotoxic Effects On Glioma Cells in Vitro - a New Class of Glioma Therapy Drugs?

2008

Rax Is Required for Fly Neuronal Development and Mouse Embryogenesis
Mechanisms of Development
2008

Jaz "Targeting" Compounds Induce G1 Cell Cycle Arrest Followed By Cell Death in Human Leukemia Cells
Blood
2008

C-Myc and Caspase-2 Are Involved in Activating Bax During Cytotoxic Drug-Induced Apoptosis
Journal of Biological Chemistry
2008

Bcl2 Negatively Regulates Dna Double-Strand-Break Repair Through a Nonhomologous End-Joining Pathway
Molecular Cell
2008

Bcl2 Enhances Induced Hematopoietic Differentiation of Murine Embryonic Stem Cells
Experimental Hematology
2008

Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Nature Medicine
2002

Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.
Journal of Biological Chemistry
2001

Research Interests

  • Dr. May's focuses on discovery-driven research involving the molecular mechanisms by which hematopoietic growth factors regulate the cell signaling responsible for efficient cell growth of both normal and malignant/leukemic hematopoietic cells. Dr. May's research is focused on regulation of apoptosis by Bcl2 and other anti- or pro-apoptotic factors. Dr. May also works on the three novel genes discovered by his laboratory: 1.) RAX (PKR-associated protein X) which is the only known cellular activator of PKR; 2.) JAZ (Just-another-zinc finger protein) which is a novel, direct activator of p53; and 3.) KOS (kinase of embryonic stem cells) which is a negative regulator of Ras and a tumor suppressor gene. His research is funded by the NCI and NHLBI of the NIH.
  • Dr. May also acts as PI for the T32 Training Grant in Cancer Biology which sponsors pre-doctoral candidates and post-doctoral fellows.