Systemic means affecting the entire body, rather than a single organ or body part.
An infection that is in the bloodstream is called a systemic infection.
An infection that affects only one body part or organ is called a localized infection.
Taber's Cyclopedic Medical Dictionary. 23rd ed. F.A. Davis Company; 2017. www.tabers.com/tabersonline/. Accessed January 27, 2017.