Thomas George, M.D.

Thomas J George, Jr, M.D., F.A.C.P.

(352) 265-0725

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Publications

Creating an mHealth App for Colorectal Cancer Screening: User-Centered Design Approach
JMIR human factors
2019

Total Neoadjuvant Therapy: A Shifting Paradigm In Locally Advanced Rectal Cancer Management.
Clinical Colorectal Cancer
2018

Thermal ablation versus wedge or segmental resection in patients with early stage hepatocellular carcinoma: a population survival analysis.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2018

The Influence of Patient Identification and Narrative Transportation on Intentions to Participate in Cancer Research.
Journal of cancer education : the official journal of the American Association for Cancer Education
2018

Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for stage II and III disease.
Cancer
2018

Phase 2 Study Of Treatment Selection Based On Tumor Thymidylate Synthase Expression In Previously Untreated Patients With Metastatic Colorectal Cancer: A Trial Of The Ecog-Acrin Cancer Research Group (E4203).

2018

Non-Surgical Management of Patients With Intrahepatic Cholangiocarcinoma in the United States, 2004-2015: An Ncdb Analysis

2018

Facilitation Or Hindrance: Physicians' Perception On Best Practice Alerts (Bpa) Usage In An Electronic Health Record System
Health Communication
2018

Design And Rational For The Precision Medicine Guided Treatment For Cancer Pain Pragmatic Clinical Trial.
Contemporary Clinical Trials
2018

Clinical Factors As A Component Of The Personalized Treatment Approach To Advanced Pancreatic Cancer: A Systematic Literature Review.
Journal Of Gastrointestinal Cancer
2018

Beyond Microsatellite Testing: Assessment of Tumor Mutational Burden Identifies Subsets of Colorectal Cancer Who May Respond to Immune Checkpoint Inhibition

2018

An Ontology-Guided Semantic Data Integration Framework to Support Integrative Data Analysis of Cancer Survival

2018

A Phase Ib Study of Ruxolitinib Plus Gemcitabine +/- Nab-Paclitaxel in Patients With Advanced Solid Tumors
Oncotargets and Therapy
2018

Synthetic Lethality in Malignant Pleural Mesothelioma With Parp1 Inhibition
Cancer Chemotherapy and Pharmacology
2017

Stereotactic Body Radiation Therapy For Oligoprogression Of Metastatic Disease From Gastrointestinal Cancers: A Novel Approach To Extend Chemotherapy Efficacy.
Oncology Letters
2017

Sociodemographic Factors Associated With Stage of Diagnosis and Treatment Uptake Among Patients With Colorectal Cancer: a Brief Report
Journal of Cancer Policy
2017

Randomized Clinical Trials In Colon And Rectal Cancer.
Surgical Oncology Clinics of North America
2017

Prognostic Value of Clinical Vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy
Journal Of The National Cancer Institute
2017

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease
Pancreas
2017

Nsc30049 Inhibits Chk1 Pathway in 5-Fu-Resistant Crc Bulk and Stem Cell Populations
Oncotarget
2017

Neoadjuvant Transarterial Radiation Lobectomy for Colorectal Hepatic Metastases: a Small Cohort Analysis on Safety, Efficacy, and Radiopathologic Correlation

2017

Innovation or Inconsistency? Framing Colorectal Cancer Guidelines to Improve Public Perceptions of Updated Screening Recommendations
Journal of Language and Social Psychology
2017

Infusion Room-Based Transition To Practice Model For Teaching Cancer Systemic Therapy Management.
Journal of Oncology Practice
2017

Human Pancreatic Cancer Cells Induce a Myd88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment
Cancer Research
2017

Explore Care Pathways Of Colorectal Cancer Patients With Social Network Analysis.
Studies in health technology and informatics
2017

Data Integration through Ontology-Based Data Access to Support Integrative Data Analysis: A Case Study of Cancer Survival.
Proceedings. IEEE International Conference on Bioinformatics and Biomedicine
2017

Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy
Journal of Gastrointestinal Surgery
2017

A Novel Microfluidic Device For Isolation Of Circulating Tumor Cells From Pancreatic Cancer Blood Samples.
Methods In Molecular Biology (Clifton, N.J.)
2017

A Clinically Applicable Muscular Index Predicts Long-Term Survival in Resectable Pancreatic Cancer
Surgery
2017

Use of Electronic Cigarettes Among Cancer Survivors in the US
American Journal of Preventive Medicine
2016

Standardization of Surgical Care in a High-Volume Center Improves Survival in Resected Pancreatic Head Cancer
American Journal of Surgery
2016

Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies
Journal of Gastrointestinal Surgery
2016

Isolation of Pancreatic Cancer Cells From a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture
American Journal of Pathology
2016

Egfr Family and Cmet Expression Profiles and Prognostic Significance in Esophagogastric Adenocarcinoma

2016

Discordant Her2 Expression And Response To Neoadjuvant Chemoradiotherapy In Esophagogastric Adenocarcinoma.

2016

Clinical, Morphologic, and Immunophenotypic Characteristics of Ampullary Carcinomas With An Emphasis on Smad4 Expression

2016

Broad Detection of Alterations Predicted to Confer Lack of Benefit From Egfr Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer
Oncologist
2016

Barriers to a Career Focus in Cancer Prevention: a Report and Initial Recommendations From the American Society of Clinical Oncology Cancer Prevention Workforce Pipeline Work Group
Journal of Clinical Oncology
2016

"It Is Just Another Test They Want To Do": Patient And Caregiver Understanding Of The Colonoscopy Procedure.
Patient Education and Counseling
2016

The Inflammatory Milieu Within the Pancreatic Cancer Microenvironment Correlates With Clinicopathologic Parameters, Chemoresistance and Survival
Bmc Cancer
2015

Small Molecule Inhibitor Ym155-Mediated Activation of Death Receptor 5 Is Crucial for Chemotherapy-Induced Apoptosis in Pancreatic Carcinoma
Molecular Cancer Therapeutics
2015

Pathways To Colonoscopy In The South: Seeds Of Health Disparities.

2015

Interobserver Variability Of Mitotic Index And Utility Of Phh3 For Risk Stratification In Gastrointestinal Stromal Tumors.
American Journal of Clinical Pathology
2015

Durable Clinical Benefit To Trastuzumab And Chemotherapy In A Patient With Metastatic Colon Adenocarcinoma Harboring Erbb2 Amplification.
Oncoscience
2015

Downstream Mediators of the Intratumoral Interferon Response Suppress Antitumor Immunity, Induce Gemcitabine Resistance and Associate With Poor Survival in Human Pancreatic Cancer
Cancer Immunology Immunotherapy
2015

A Metastatic Colon Adenocarcinoma Harboring Braf V600E Has A Durable Major Response To Dabrafenib/Trametinib And Chemotherapy.
Oncotargets and Therapy
2015

Src Inhibition Is Still a Relevant Target in Pancreatic Cancer
Oncologist
2014

Phase 1/2 Study of Krn330, a Fully Human Anti-A33 Monoclonal Antibody, Plus Irinotecan as Second-Line Treatment for Patients With Metastatic Colorectal Cancer
Investigational New Drugs
2014

Fellowship Engagement in Hematology/Oncology Professionalism Training
Journal of Clinical Oncology
2014

Feasibility/Acceptability of Quality of Life Research Among Distressed Individuals Affected By Pancreatic Cancer
Psycho-Oncology
2014

Effects of Patient and Caregiver Literacy On Preference for Physician-Led Medical Decisions
Psycho-Oncology
2014

Comparison of C-Met Immunoreactivity in Surgically Treated Gastroesophageal Adenocarcinoma Using Two Commercially Available Antibodies
Laboratory Investigation
2014

Capture, Release And Culture Of Circulating Tumor Cells From Pancreatic Cancer Patients Using An Enhanced Mixing Chip.
Lab on a Chip
2014

Treatment Outcomes and Prognostic Factors of Intrahepatic Cholangiocarcinoma
Oncology Reports
2013

Proton Therapy With Concomitant Capecitabine for Pancreatic and Ampullary Cancers Is Associated With a Low Incidence of Gastrointestinal Toxicity
Acta Oncologica
2013

Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy

2013

Argininosuccinate Synthase as a Novel Biomarker for Inflammatory Conditions
Biomarkers
2013

Proton Therapy for Pancreatic Cancer - Toxicity Data and Early Outcomes
Pancreas
2012

Squamous Cell Carcinoma of the Anal Margin the University of Florida Experience
American Journal of Clinical Oncology-Cancer Clinical Trials
2011

Protocol Information Provides Opportunity for Patient Safety and Quality Improvement
Journal of Clinical Oncology
2011

Multiagent Regimens for Metastatic Colorectal Cancer: If Some Is Good, More Must Be Better

2011

Klatskin Tumor- Clinical Outcome and Prognostic Factors
Higher Education Policy
2011

Hepatitis B Reactivation and Rituximab in the Oncology Practice
Oncologist
2010

Gastroduodenal Ulcerations as a Delayed Complication of Hepatic Metastasis Radioembolization
Journal of Clinical Oncology
2010

Definitive Radiotherapy for Squamous Cell Carcinoma of the Anal Canal
American Journal of Clinical Oncology-Cancer Clinical Trials
2010

Adequacy of Published Oncology Randomized Controlled Trials To Provide Therapeutic Details Needed for Clinical Application

2010

A phase II trial of neoadjuvant capecitabine combined with hyperfractionated accelerated radiation therapy in locally advanced rectal cancer.
American Journal of Clinical Oncology-Cancer Clinical Trials
2010

A Phase II Trial of Neoadjuvant Capecitabine Combined With Hyperfractionated Accelerated Radiation Therapy in Locally Advanced Rectal Cancer
American Journal of Clinical Oncology-Cancer Clinical Trials
2010

Radiotherapy in the Treatment of Resectable Rectal Adenocarcinoma
American Journal of Clinical Oncology-Cancer Clinical Trials
2009

Pancreatic Heterotopia Masquerading As Duodenal Carcinoid.
Gastrointestinal Cancer Research : Gcr
2009

Impact of a Simple Intervention That Improves Colon Cancer Lymph Node Yield and Assessement
Journal of Clinical Oncology
2009

Impact of An Annual Hematology/Oncology Fellow Wet Laboratory Program On Fund of Biomedical Knowledge
Blood
2009

Adjuvant radiotherapy for cutaneous melanoma.

2008

Rationale and appropriate use of chemotherapy and radiotherapy for pancreatic ductal adenocarcinoma.
Current Gastroenterology Reports
2006

Factors associated with parameters of engraftment potential of umbilical cord blood.
Transfusion
2006

Anesthetic Properties Of A Propofol Microemulsion In Dogs.
Anesthesia & analgesia (Online)
2006

Research Interests

Clinical research in gastrointestinal malignancies is a primary aspect of Dr. George’s academic interests.  Specific areas of focus include active participation and development of clinical trials to promote novel drug application in patient care, quality of life/cancer care decision making, and identification of predictive markers for individualized therapy.  He has been a 10 year Gubernatorial appointee to the Executive Committee and immediate past Chair of the Florida Cancer Control and Research and Advisory Council which advises the legislature on matters related to cancer care and research in the state. He is a dedicated mentor and teacher of fellows, residents, and students in the College of Medicine and junior faculty both at UF and other major institutions.
Experimental Therapeutics
Dr. George is involved as a Principle Investigator in numerous clinical trials aimed at determining the optimal treatment for patients with gastrointestinal malignancies and brining new therapies to patients with advanced cancers.  Collaboration includes numerous national clinical trial groups as well as the National Cancer Institute.  Representative protocols include studies in colon, rectal, pancreatic, esophagogastric, hepatobiliary and other treatment refractory cancers.  These novel therapies hold the promise of becoming the next breakthrough in cancer patient care. 
Personalized Oncology
As cancer care becomes more complex, focus on a tailored approach to individualized treatments which maximize benefit while minimizing risk is critical.  Research involving the identification of specific markers or elements of a patient or their cancer which will predict, in advance, response to a given therapy is an area of active investigation.  The incorporation of new molecular markers, gene expression profiling, and pharmacogenomics into clinical care will help to provide patients with truly personalized care. 
Quality of Life and Decision Making
Patients and their loved ones facing the new diagnosis of a cancer face a variety of potentially overwhelming treatment options and decisions.  Collaboration with behavioral scientists, communication experts, and others are helping to break down the complex process of decision making in an attempt to determine how best to deliver treatment options and maximize quality of life.
Educating the Next Generation of Oncologists
The next generation holds the keys to continuing the work currently ongoing in cancer biology, therapeutics, and patient care.  Cancer therapies and knowledge are constantly changing and medicine requires a lifelong commitment to education. Development of novel educational tools, training modules, and advanced curricula aimed at providing oncologists with the skills needed to practice state of the art medicine while maintaining the humanism and sensitivity required for being entrusted with the honor of caring for patients with cancer is an area of ongoing professional and research interest.

Active Research Studies