Tiago Machuca, M.D.

Tiago N Machuca, M.D., Ph.D. - Research & Publications

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Machuca TN, Cypel M, Zhao Y, Grasemann H, Tavasoli F, Yeung JC, Bonato R, Chen M, Zamel R, Chun YM, Guan Z, de Perrot M, Waddell TK, Liu M, Keshavjee S. The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion. J Heart Lung Transplant. 2015 Jan 16. pii: S1053-2498(15)00005-4. doi: 10.1016/j.healun.2015.01.003. [Epub ahead of print] PubMed PMID: 25907141.
Machuca T, de Perrot M. When to refer a patient with chronic thromboembolic pulmonary hypertension for pulmonary endarterectomy. Can J Cardiol. 2015 Apr;31(4):509-14. doi: 10.1016/j.cjca.2015.01.042. Epub 2015 Feb 7. PubMed PMID: 25840100.

Machuca TN, Mercier O, Collaud S, Tikkanen J, Krueger T, Yeung JC, Chen M, Azad S, Singer L, Yasufuku K, de Perrot M, Pierre A, Waddell TK, Keshavjee S, Cypel M. Lung transplantation with donation after circulatory determination of death donors and the impact of ex vivo lung perfusion. Am J Transplant. 2015 Apr;15(4):993-1002. doi: 10.1111/ajt.13124. Epub 2015 Mar 13. PubMed PMID: 25772069.

Ko M, dos Santos PR, Machuca TN, Marseu K, Waddell TK, Keshavjee S, Cypel M. Use of single-cannula venous-venous extracorporeal life support in the management of life-threatening airway obstruction. Ann Thorac Surg. 2015 Mar;99(3):e63-5. doi: 10.1016/j.athoracsur.2014.12.033. PubMed PMID: 25742860.

Machuca TN, Collaud S, Mercier O, Cheung M, Cunningham V, Kim SJ, Azad S, Singer L, Yasufuku K, de Perrot M, Pierre A, McRae K, Waddell TK, Keshavjee S, Cypel M. Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation. J Thorac Cardiovasc Surg. 2015 Apr;149(4):1152-7. doi: 10.1016/j.jtcvs.2014.11.039. Epub 2014 Nov 21. PubMed PMID: 25583107.

Tikkanen JM, Cypel M, Machuca TN, Azad S, Binnie M, Chow CW, Chaparro C, Hutcheon M, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S, Singer LG. Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation. J Heart Lung Transplant. 2015 Apr;34(4):547-56. doi: 10.1016/j.healun.2014.09.044. Epub 2014 Oct 24. PubMed PMID: 25476845.

Machuca TN, Cypel M, Yeung JC, Bonato R, Zamel R, Chen M, Azad S, Hsin MK, Saito T, Guan Z, Waddell TK, Liu M, Keshavjee S. Protein expression profiling predicts graft performance in clinical ex vivo lung perfusion. Ann Surg. 2015 Mar;261(3):591-7. doi: 10.1097/SLA.0000000000000974. PubMed PMID: 25371129.

Machuca TN, Cypel M. Ex vivo lung perfusion. J Thorac Dis. 2014 Aug;6(8):1054-62. doi: 10.3978/j.issn.2072-1439.2014.07.12. Review. PubMed PMID: 25132972; PubMed Central PMCID: PMC4133548.

Collaud S, Machuca T, Mercier O, Waddell TK, Yasufuku K, Pierre AF, Darling GE, Cypel M, Rampersaud YR, Lewis SJ, Shepherd FA, Leighl NB, Cho JB, Bezjak A, Keshavjee S, de Perrot M. Long-term outcome after resection of non-small cell lung cancer invading the thoracic inlet. Ann Thorac Surg. 2014 Sep;98(3):962-7. doi: 10.1016/j.athoracsur.2014.05.015. Epub 2014 Jul 25. PubMed PMID: 25069687.

Machuca TN, Cypel M, Keshavjee S. Advances in lung preservation. Surg Clin North Am. 2013 Dec;93(6):1373-94. doi: 10.1016/j.suc.2013.08.001. Epub 2013 Oct 17. Review. PubMed PMID: 24206857.

Cao H, Machuca TN, Yeung JC, Wu J, Du K, Duan C, Hashimoto K, Linacre V, Coates AL, Leung K, Wang J, Yeger H, Cutz E, Liu M, Keshavjee S, Hu J. Efficient gene delivery to pig airway epithelia and submucosal glands using helper-dependent adenoviral vectors. Mol Ther Nucleic Acids. 2013 Oct 8;2:e127. doi: 10.1038/mtna.2013.55. PubMed PMID: 24104599; PubMed Central PMCID: PMC3890457.

Machuca TN, Hsin MK, Ott HC, Chen M, Hwang DM, Cypel M, Waddell TK, Keshavjee S. Injury specific ex vivo treatment of the donor lung: pulmonary thrombolysis followed by successful lung transplantation. Am J Respir Crit Care Med. 2013 Oct 1;188(7):878-80. doi: 10.1164/rccm.201302-0368LE. PubMed PMID: 24083866.