UF Health MedMatters

UF Researchers Discover New Potential Treatment for Retinal Degeneration

For scientists pursuing retinal degeneration treatments, there is no shortage of culprits: More than 270 genes are known to cause the disease, which is a leading cause of blindness. That underscores the need to develop therapies that are broadly effective regardless of the gene defect. University of Florida Health researchers led by W. Clay Smith, PhD, an associate professor of ophthalmology, have devised a modified protein to improve the function and survival of rod and cone photoreceptors.Eye degeneration image

The altered protein, arrestin1, works by boosting energy output in the photoreceptors. Improving their use of glucose slowed retinal degeneration and delayed vision loss in mouse models, the researchers found. The discovery may be broadly applicable to other inherited forms of retinal degeneration because the technique does not target the specific underlying genetic defect.

The findings were published Jan. 26 in the journal Human Gene Therapy.

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University of Florida Health Shands Hospital has been recognized among the nation’s best hospitals in seven adult medical specialties. Overall, UF Health Shands Hospital was recognized as one of the best hospitals in Florida. In addition to being ranked among the nation’s top 50 hospitals in seven specialties, UF Health Shands Hospital also was listed as “high performing” in seven specialties, including abdominal aortic aneurysm repair, colon cancer surgery, COPD, heart failure, lung cancer surgery, neurology & neurosurgery and orthopaedics.