Westley Reeves, M.D.

Westley H Reeves, M.D. - Research & Publications

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Publications

Colocalization of Antigen-Specific B and T Cells Within Ectopic Lymphoid Tissue Following Immunization With Exogenous Antigen
Journal of Immunology
2019

"Lupoid Hepatitis" in SLE Patients and Mice With Experimental Lupus
Journal of Immunology
2019

Maintenance of Anti-Sm/Rnp Autoantibody Production By Plasma Cells Residing in Ectopic Lymphoid Tissue and Bone Marrow Memory B Cells
Arthritis and Rheumatism
2019

Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2019

Rapid Serological Detection of Autoantibodies Associated With Sjogren's Syndrome
Expert Review of Clinical Immunology
2019

Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism
2019

Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients
Blood
2019

Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Arthritis and Rheumatism
2019

Patients With Pulmonary Tuberculosis Are Frequently Positive for Anti-Cyclic Citrullinated Peptide Antibodies, But Their Sera Also React With Unmodified Arginine-Containing Peptide
Lupus
2019

Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Arthritis and Rheumatism
2019

Neutrophil Gelatinase Associated Lipocalin (Ngal/Lipocalin-2) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2019

Henry Kunkel, Stephanie Smith, clinical immunology, and split genes.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics
2019

Citrulline Dependence of Anti-Cyclic Citrullinated Peptide Antibodies in Systemic Lupus Erythematosus as a Marker of Deforming/Erosive Arthritis
Infection and Immunity
2019

Autoantibodies To Survival of Motor Neuron Complex in Patients With Polymyositis: Immunoprecipitation of D, E, F, and G Proteins Without Other Components of Small Nuclear Ribonucleoproteins
Journal of Immunology
2019

Trif-Dependent Innate Immune Activation Is Critical for Survival To Neonatal Gram-Negative Sepsis
Arthritis & Rheumatology
2019

Labial salivary gland biopsies in Sjögren's syndrome: still the gold standard?
Arthritis and Rheumatism
2019

Critical Role for Cxc Ligand 10/Cxc Receptor 3 Signaling in the Murine Neonatal Response To Sepsis
Arthritis and Rheumatism
2019

Pleiotropic Ifn-Dependent and -Independent Effects of Irf5 On the Pathogenesis of Experimental Lupus
Arthritis Research & Therapy
2019

Mechanisms of Tumor Necrosis Factor Alpha Antagonist-Induced Lupus in a Murine Model
Journal of Cell Science
2019

High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis Research & Therapy
2019

Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Modern Pathology
2019

Atypical Clinical Presentation of a Subset of Patients With Anti-Rna Polymerase III - Non-Scleroderma Cases Associated With Dominant Rna Polymerase I Reactivity and Nucleolar Staining
Archivum Immunologiae et Therapiae Experimentalis
2019

The Reprogrammed Pancreatic Progenitor-Like Intermediate State of Hepatic Cells Is More Susceptible To Pancreatic Beta Cell Differentiation
Arthritis and Rheumatism
2019

Frequent Coexistence of Anti-Topoisomerase I and Anti-U1Rnp Autoantibodies in African American Patients Associated With Mild Skin Involvement: a Retrospective Clinical Study
Journal of Clinical Immunology
2019

Pathogenic Role of B Cells in the Development of Diffuse Alveolar Hemorrhage Induced By Pristane
European Journal of Immunology
2019

Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
2019

Regulation of Aberrant Cd4 T Cell Activation By Suppressor of Cytokine Signaling-1 (Socs1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Arthritis and Rheumatism
2019

Positive Correlation of Stat1 and Mir-146a With Anemia in Patients With Systemic Lupus Erythematosus
Arthritis Research & Therapy
2019

Altered Mir-146a Expression in Sjogren's Syndrome and Its Functional Role in Innate Immunity
Arthritis Research & Therapy
2019

Angiopoietin-Like Protein 8 (Betatrophin) Is a Stress-Response Protein That Down-Regulates Expression of Adipocyte Triglyceride Lipase
Arthritis Research & Therapy
2019

Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
American Journal of Translational Research
2019

Monocyte Surface Expression of Fc Gamma Receptor Ri (Cd64), a Biomarker Reflecting Type-I Interferon Levels in Systemic Lupus Erythematosus
Clinical Rheumatology
2019

Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research & Therapy
2019

Increased Expression of Fc Gamma Ri/Cd64 On Circulating Monocytes Parallels Ongoing Inflammation and Nephritis in Lupus
Arthritis Research & Therapy
2019

Novel Autoantigens in Type 1 Diabetes
Immunology and Cell Biology
2019

Gender and Ethnicity Differences in the Prevalence of Scleroderma-Related Autoantibodies
Journal of Experimental Medicine
2019

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Journal of the American Dental Association
2019

Reduced Levels of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients Under Treatment With Prednisone, Mycophenolate Mofetil, Or Hydroxychloroquine, Except in a High Stat1 Subset
Arthritis & Rheumatology
2019

Serum Autoantibodies in Pristane Induced Lupus Are Regulated By Neutrophil Gelatinase Associated Lipocalin
Journal of Immunology
2019

Formation of Gw/P Bodies as Marker for Microrna-Mediated Regulation of Innate Immune Signaling in Thp-1 Cells
Journal of Immunological Methods
2019

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus.
International Journal of Clinical and Experimental Pathology
2019

Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Arthritis and Rheumatism
2019

Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus
Modern Pathology
2019

A Novel Type Iifn-Producing Cell Subset in Murine Lupus
Trends in Immunology
2019

Muscarinic Type 3 Receptor Autoantibodies Are Associated With Anti-Ssa/Ro Autoantibodies in Sjogren's Syndrome
Journal of Immunology
2019

Breast Implant-Associated Alk-Negative Anaplastic Large Cell Lymphoma: a Case Report and Discussion of Possible Pathogenesis
Arthritis Research & Therapy
2019

Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Journal of Neuroimmunology
2019

Pancreatic Duodenal Homeobox 1 Protein Is a Novel Beta-Cell-Specific Autoantigen for Type I Diabetes
Frontiers in Bioscience-Landmark
2019

Induction of Autoimmunity By Pristane and Other Naturally Occurring Hydrocarbons
Arthritis and Rheumatism
2019

Neutrophil Gelatinase Associated Lipocalin (Ngal) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2019

Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis Research & Therapy
2019

Endogenous Type-I Interferon Activity Is Not Associated With Depression Or Fatigue in Systemic Lupus Erythematosus
Journal of the American Dental Association
2019

Indole-3-Carbinol Improves Survival in Lupus-Prone Mice By Inducing Tandem B- and T-Cell Differentiation Blockades
Journal of Autoimmunity
2019

Autoantibody To Na14 Is An Independent Marker Primarily for Sjogren's Syndrome
American Journal of Pathology
2019

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis & Rheumatology
2019

B Cell Proliferation, Somatic Hypermutation, Class Switch Recombination, and Autoantibody Production in Ectopic Lymphoid Tissue in Murine Lupus
Journal of Immunology
2019

Autoantibodies To Transcription Intermediary Factor (Tif)1 Beta Associated With Dermatomyositis
PLOS One
2019

Salivary Dysfunction and Quality of Life in Sjogren Syndrome - a Critical Oral-Systemic Connection
Arthritis Research & Therapy
2019

Induction of lupus autoantibodies by adjuvants.
Arthritis and Rheumatism
2019

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
Arthritis and Rheumatism
2019

A Novel Mechanism for Generating the Interferon Signature in Lupus Opsonization of Dead Cells By Complement and Igm
Arthritis and Rheumatism
2019

Il-1 Alpha Modulates Neutrophil Recruitment in Chronic Inflammation Induced By Hydrocarbon Oil
Arthritis and Rheumatism
2019

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts
Lupus
2019

Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitro.
Arthritis Research & Therapy
2019

Defective Response of Cd4(+) T Cells To Retinoic Acid and Tgf Beta in Systemic Lupus Erythematosus
Journal of Experimental Medicine
2019

A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
International Immunology
2019

Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Trends in Immunology
2019

Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis Research & Therapy
2019

Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Autoimmunity Reviews
2019

Coexistence of Anti-Rna Polymerase Iii and Anti-U1Rnp Antibodies in Patients With Systemic Lupus Erythematosus: Two Cases Without Features of Scleroderma
Kidney International
2019

Elevated Signal Transducers and Activators of Transcription 1 Correlates With Increased C-C Motif Chemokine Ligand 2 and C-X-C Motif Chemokine 10 Levels in Peripheral Blood of Patients With Systemic Lupus Erythematosus
Journal of Immunology
2019

Tlr7-Dependent and Fc Gamma R-Independent Production of Type I Interferon in Experimental Mouse Lupus
Arthritis and Rheumatism
2019

X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus.
Arthritis Research & Therapy
2019

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons.
Archivum Immunologiae et Therapiae Experimentalis
2019

Upregulated Mir-146a Expression in Peripheral Blood Mononuclear Cells From Rheumatoid Arthritis Patients
Journal of Immunology
2019

AutoAbSC.Org -- Autoantibody Standardization Committee in 2006.
American Journal of Pathology
2019

Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane.
Journal of Immunology
2019

A Novel Subset of Anti-Inflammatory Cd138(+) Macrophages Is Deficient in Mice With Experimental Lupus
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics
2019

Tlr-7-Dependent and Fc Gamma R-Independent Production of Type I Interferon in Experimental Murine Lupus
Arthritis and Rheumatism
2019

Maintenance of Autoantibody Production in Pristane-Induced Murine Lupus
Frontiers in Immunology
2019

Monocyte and macrophage abnormalities in systemic lupus erythematosus.
Arthritis and Rheumatism
2019

Neutrophil Gelatinase Associated Lipocalin (Ngal) Deficiency Accelerates the Onset of Serum Autoantibodies in Pristane Induced Lupus
International Journal of Clinical and Experimental Pathology
2019

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation

2019

Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm

2019

Labial Salivary Gland Biopsies in Sjogren'S Syndrome: Still the Gold Standard?

2019

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?

2019

Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus

2019

Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.

2019

Novel Detection of Pancreatic and Duodenal Homeobox 1 Autoantibodies (Paa) in Human Sera Using Luciferase Immunoprecipitation Systems (Lips) Assay

2019

Research Interests

Dr. Reeves' and associates' research focuses on the mechanisms of autoimmunity in systemic autoimmune diseases such as systemic lupus erythematosus (SLE), polymyositis, and Sjogren's syndrome. They have found that the hydrocarbon oil pristane induces a lupus-like syndrome in normal mice characterized by the production of high levels of antinuclear antibodies specific for SLE as well as immune complex-mediated glomerulonephritis and arthritis. Using cytokine knockout mice, they have found that pristane-induced lupus is strongly dependent on IL-6 and interferon-g . The hypothesis that different manifestations of lupus (clinical and serological) result from the overproduction of these and other cytokines is being investigated in patients from the UF Lupus Research Center and in animal models in order to understand the interrelationships between genetic predisposition and environmental triggers of autoimmune disease.