Westley Reeves, M.D.

Westley H Reeves, M.D. - Research & Publications

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Publications

Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Blood
2012

Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus
Frontiers in Immunology
2015

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts
PLOS One
2015

A Novel Subset of Anti-Inflammatory Cd138(+) Macrophages Is Deficient in Mice With Experimental Lupus
Journal of Immunology
2017

Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus
Arthritis \& Rheumatology
2017

A Novel Mechanism for Generating the Interferon Signature in Lupus Opsonization of Dead Cells By Complement and Igm
Arthritis \& Rheumatology
2016

Muscarinic Type 3 Receptor Autoantibodies Are Associated With Anti-Ssa/Ro Autoantibodies in Sjogren's Syndrome
Journal of Immunological Methods
2016

Angiopoietin-Like Protein 8 (Betatrophin) Is a Stress-Response Protein That Down-Regulates Expression of Adipocyte Triglyceride Lipase
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
2016

Maintenance of Autoantibody Production in Pristane-Induced Murine Lupus
Arthritis Research \& Therapy
2015

Trif-Dependent Innate Immune Activation Is Critical for Survival To Neonatal Gram-Negative Sepsis
Journal of Immunology
2015

Mechanisms of Tumor Necrosis Factor Alpha Antagonist-Induced Lupus in a Murine Model
Arthritis \& Rheumatology
2015

Positive Correlation of Stat1 and Mir-146a With Anemia in Patients With Systemic Lupus Erythematosus
Journal of Clinical Immunology
2014

Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research \& Therapy
2014

Reduced Levels of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients Under Treatment With Prednisone, Mycophenolate Mofetil, Or Hydroxychloroquine, Except in a High Stat1 Subset
Arthritis Research \& Therapy
2014

Elevated Signal Transducers and Activators of Transcription 1 Correlates With Increased C-C Motif Chemokine Ligand 2 and C-X-C Motif Chemokine 10 Levels in Peripheral Blood of Patients With Systemic Lupus Erythematosus
Arthritis Research \& Therapy
2014

Neutrophil Gelatinase Associated Lipocalin (Ngal/Lipocalin-2) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Arthritis and Rheumatism
2013

Regulation of Aberrant Cd4 T Cell Activation By Suppressor of Cytokine Signaling-1 (Socs1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Arthritis and Rheumatism
2013

Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism
2013

The Reprogrammed Pancreatic Progenitor-Like Intermediate State of Hepatic Cells Is More Susceptible To Pancreatic Beta Cell Differentiation
Journal of Cell Science
2013

Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology
2013

Neutrophil Gelatinase Associated Lipocalin (Ngal) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2013

Maintenance of Anti-Sm/Rnp Autoantibody Production By Plasma Cells Residing in Ectopic Lymphoid Tissue and Bone Marrow Memory B Cells
Journal of Immunology
2013

Breast Implant-Associated Alk-Negative Anaplastic Large Cell Lymphoma: a Case Report and Discussion of Possible Pathogenesis
International Journal of Clinical and Experimental Pathology
2013

Novel Detection of Pancreatic and Duodenal Homeobox 1 Autoantibodies (Paa) in Human Sera Using Luciferase Immunoprecipitation Systems (Lips) Assay
International Journal of Clinical and Experimental Pathology
2013

Novel Autoantigens in Type 1 Diabetes
American Journal of Translational Research
2013

Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
Arthritis and Rheumatism
2012

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?
Arthritis and Rheumatism
2012

Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Arthritis and Rheumatism
2012

Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism
2012

Neutrophil Gelatinase Associated Lipocalin (Ngal) Deficiency Accelerates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2012

Pleiotropic Ifn-Dependent and -Independent Effects of Irf5 On the Pathogenesis of Experimental Lupus
Journal of Immunology
2012

Coexistence of Anti-Rna Polymerase Iii and Anti-U1Rnp Antibodies in Patients With Systemic Lupus Erythematosus: Two Cases Without Features of Scleroderma
Lupus
2012

Autoantibodies To Transcription Intermediary Factor (Tif)1 Beta Associated With Dermatomyositis
Arthritis Research \& Therapy
2012

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism
2011

Gender and Ethnicity Differences in the Prevalence of Scleroderma-Related Autoantibodies
Clinical Rheumatology
2011

Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis and Rheumatism
2011

Pathogenic Role of B Cells in the Development of Diffuse Alveolar Hemorrhage Induced By Pristane
Modern Pathology
2011

Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism
2011

Altered Mir-146a Expression in Sjogren's Syndrome and Its Functional Role in Innate Immunity
European Journal of Immunology
2011

Autoantibodies To Survival of Motor Neuron Complex in Patients With Polymyositis: Immunoprecipitation of D, E, F, and G Proteins Without Other Components of Small Nuclear Ribonucleoproteins
Arthritis and Rheumatism
2011

Critical Role for Cxc Ligand 10/Cxc Receptor 3 Signaling in the Murine Neonatal Response To Sepsis
Infection and Immunity
2011

Il-1 Alpha Modulates Neutrophil Recruitment in Chronic Inflammation Induced By Hydrocarbon Oil
Journal of Immunology
2011

Frequent Coexistence of Anti-Topoisomerase I and Anti-U1Rnp Autoantibodies in African American Patients Associated With Mild Skin Involvement: a Retrospective Clinical Study
Arthritis Research \& Therapy
2011

Defective Response of Cd4(+) T Cells To Retinoic Acid and Tgf Beta in Systemic Lupus Erythematosus
Arthritis Research \& Therapy
2011

Atypical Clinical Presentation of a Subset of Patients With Anti-Rna Polymerase III - Non-Scleroderma Cases Associated With Dominant Rna Polymerase I Reactivity and Nucleolar Staining
Arthritis Research \& Therapy
2011

Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus
Archivum Immunologiae et Therapiae Experimentalis
2010

Endogenous Type-I Interferon Activity Is Not Associated With Depression Or Fatigue in Systemic Lupus Erythematosus
Journal of Neuroimmunology
2010

Formation of Gw/P Bodies as Marker for Microrna-Mediated Regulation of Innate Immune Signaling in Thp-1 Cells
Immunology and Cell Biology
2010

Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis Research \& Therapy
2010

Monocyte Surface Expression of Fc Gamma Receptor Ri (Cd64), a Biomarker Reflecting Type-I Interferon Levels in Systemic Lupus Erythematosus
Arthritis Research \& Therapy
2010

Pancreatic Duodenal Homeobox 1 Protein Is a Novel Beta-Cell-Specific Autoantigen for Type I Diabetes
Modern Pathology
2010

Monocyte and macrophage abnormalities in systemic lupus erythematosus.
Archivum Immunologiae et Therapiae Experimentalis
2010

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation
American Journal of Pathology
2009

Induction of Autoimmunity By Pristane and Other Naturally Occurring Hydrocarbons
Trends in Immunology
2009

B Cell Proliferation, Somatic Hypermutation, Class Switch Recombination, and Autoantibody Production in Ectopic Lymphoid Tissue in Murine Lupus
Journal of Immunology
2009

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons.
Trends in Immunology
2009

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis Research \& Therapy
2009

Increased Expression of Fc Gamma Ri/Cd64 On Circulating Monocytes Parallels Ongoing Inflammation and Nephritis in Lupus
Arthritis Research \& Therapy
2009

Autoantibody To Na14 Is An Independent Marker Primarily for Sjogren's Syndrome
Frontiers in Bioscience
2009

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
American Journal of Pathology
2009

Tlr7-Dependent and Fc Gamma R-Independent Production of Type I Interferon in Experimental Mouse Lupus
Journal of Experimental Medicine
2008

High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism
2008

Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism
2008

Labial Salivary Gland Biopsies in Sjogren'S Syndrome: Still the Gold Standard?
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics
2008

Tlr-7-Dependent and Fc Gamma R-Independent Production of Type I Interferon in Experimental Murine Lupus
Arthritis and Rheumatism
2008

Colocalization of Antigen-Specific B and T Cells Within Ectopic Lymphoid Tissue Following Immunization With Exogenous Antigen
Journal of Immunology
2008

Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism
2008

Patients With Pulmonary Tuberculosis Are Frequently Positive for Anti-Cyclic Citrullinated Peptide Antibodies, But Their Sera Also React With Unmodified Arginine-Containing Peptide
Arthritis and Rheumatism
2008

A Novel Type Iifn-Producing Cell Subset in Murine Lupus
Journal of Immunology
2008

Salivary Dysfunction and Quality of Life in Sjogren Syndrome - a Critical Oral-Systemic Connection
Journal of the American Dental Association
2008

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus.
Journal of Experimental Medicine
2008

Labial salivary gland biopsies in Sjögren's syndrome: still the gold standard?
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics
2008

Upregulated Mir-146a Expression in Peripheral Blood Mononuclear Cells From Rheumatoid Arthritis Patients
Arthritis Research \& Therapy
2008

Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Journal of the American Dental Association
2008

AutoAbSC.Org -- Autoantibody Standardization Committee in 2006.
Autoimmunity Reviews
2007

Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert Review of Clinical Immunology
2007

X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus.
International Immunology
2003

Henry Kunkel, Stephanie Smith, clinical immunology, and split genes.
Lupus
2003

Induction of lupus autoantibodies by adjuvants.
Journal of Autoimmunity
2003

Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane.
Kidney International
2001

Research Interests

Dr. Reeves' and associates' research focuses on the mechanisms of autoimmunity in systemic autoimmune diseases such as systemic lupus erythematosus (SLE), polymyositis, and Sjogren's syndrome. They have found that the hydrocarbon oil pristane induces a lupus-like syndrome in normal mice characterized by the production of high levels of antinuclear antibodies specific for SLE as well as immune complex-mediated glomerulonephritis and arthritis. Using cytokine knockout mice, they have found that pristane-induced lupus is strongly dependent on IL-6 and interferon-g . The hypothesis that different manifestations of lupus (clinical and serological) result from the overproduction of these and other cytokines is being investigated in patients from the UF Lupus Research Center and in animal models in order to understand the interrelationships between genetic predisposition and environmental triggers of autoimmune disease.