W. Stratford May, Jr., M.D., Ph.D.
Poor Peripheral Blood Stem Cell Mobilization Correlates With Worse Long-Term Outcomes in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
Biology of Blood and Marrow Transplantation
Pkr Inhibits the DNa Damage Response, and Is Associated With Poor Survival in Aml and Accelerated Leukemia in Nhd13 Mice
Trim29 Suppresses Twist1 and Invasive Breast Cancer Behavior
Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product
Neoplasia (Basingstoke. Online)
Pkr Cooperates With An Mds Driver Mutation To Worsen Cytopenias and Promote Acute Leukemia
Pkr Negatively Regulates Leukemia Progression in Association With Pp2a Activation, Bcl-2 Inhibition and Increased Apoptosis
Blood Cancer Journal
The Rax/Pact-Pkr Stress Response Pathway Promotes P53 Sumoylation and Activation Leading To G(1) Arrest
Increased Expression of the Dsrna-Activated Protein Kinase Pkr in Breast Cancer Promotes Sensitivity To Doxorubicin
Jaz Mediates G(1) Cell Cycle Arrest By Interacting With and Inhibiting E2F1
Tnk1/Kos1: a novel tumor suppressor.
Transactions of the American Clinical and Climatological Association
Aberrant Ras Activation Associated With Functional Loss of Tnk1/Kos1 in Human B-Cell Lymphoma
Protein Phosphatase 2a Inactivates Bcl2's Antiapoptotic Function By Dephosphorylation and Up-Regulation of Bcl2-P53 Binding
Loss of Tnk1/Kos1 in Mice Is Associated With B-Lymphomas Specifically Dlbcl
Functional Characterization of the Murine Tnk1 Promoter
Expression of Jaz in Multiple Myeloma and Its Potential Role as a Novel Molecular Target
A Novel Role for Uric Acid in Acute Kidney Injury Associated With Tumour Lysis Syndrome
Nephrology Dialysis Transplantation
Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors
Structure-Based Jaz Ligand-Ji and Its Analogues Show Strong Cytotoxic Effects On Glioma Cells in Vitro - a New Class of Glioma Therapy Drugs?
Journal of Neuropathology and Experimental Neurology
Rax Is Required for Fly Neuronal Development and Mouse Embryogenesis
Mechanisms of Development
Jaz "Targeting" Compounds Induce G1 Cell Cycle Arrest Followed By Cell Death in Human Leukemia Cells
C-Myc and Caspase-2 Are Involved in Activating Bax During Cytotoxic Drug-Induced Apoptosis
Journal of Biological Chemistry
Bcl2 Negatively Regulates Dna Double-Strand-Break Repair Through a Nonhomologous End-Joining Pathway
Bcl2 Enhances Induced Hematopoietic Differentiation of Murine Embryonic Stem Cells
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.
Journal of Biological Chemistry
- Dr. May's focuses on discovery-driven research involving the molecular mechanisms by which hematopoietic growth factors regulate the cell signaling responsible for efficient cell growth of both normal and malignant/leukemic hematopoietic cells. Dr. May's research is focused on regulation of apoptosis by Bcl2 and other anti- or pro-apoptotic factors. Dr. May also works on the three novel genes discovered by his laboratory: 1.) RAX (PKR-associated protein X) which is the only known cellular activator of PKR; 2.) JAZ (Just-another-zinc finger protein) which is a novel, direct activator of p53; and 3.) KOS (kinase of embryonic stem cells) which is a negative regulator of Ras and a tumor suppressor gene. His research is funded by the NCI and NHLBI of the NIH.
- Dr. May also acts as PI for the T32 Training Grant in Cancer Biology which sponsors pre-doctoral candidates and post-doctoral fellows.