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Gut Organoid Study

  • Status
    Accepting Candidates
  • Age
    18 Years - 80 Years
  • Sexes
  • Healthy Volunteers
    Accepts Healthy Volunteers


The study will compare basic properties of gut epithelia of hypertensive and normotensive reference subjects. The study will determine if there are fundamental differences in the gut epithelium in hypertension compared to normotension.


Full study title Gut Inflammation and Gut-Gut Microbiome Interactions in the Pathogenesis of Hypertension
Protocol number OCR34622 ID NCT04497727


Inclusion Criteria:

  • Inclusion/exclusion criteria for hypertension participants

  • Ages: 18-80 years old with a weight greater than or equal to 110 lbs

  • Diagnosis of hypertension or without hypertension for the reference cohort. 2017 ACC/AHA (American College of Cardiology/American Heart Association) definition for hypertension (systolic blood pressure ≥130 mmHg and/or diastolic BP ≥80 mmHg) will be used.

  • Scheduled elective colonoscopy

Exclusion Criteria:

  • Hypertensive or reference individuals with history of autoimmune disease or other chronic inflammatory conditions.

  • Pregnant or have been pregnant in the last six months.

  • Antibiotic treatment within two months of study enrollment

  • Currently taking a medication (e.g. antibiotic, anti-inflammatory agents, glucocorticoids, other immune modulating medications, antacids or proton pump inhibitor drugs like Prilosec) known to modify gut microbiota.

  • Unwilling to discontinue using probiotics for at least two weeks before scheduled biopsy.

  • History of intestinal surgery, inflammatory bowel disease, celiac disease, lactose intolerance, chronic pancreatitis or other malabsorption disorder.

  • History of blood transfusion within 4 weeks.

  • Subjects who, in the opinion of the investigator, will be uncooperative or unable to comply with study procedures

Lead researcher

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    Primary contact

  2. Step

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