Tropical Weather Alert: For the latest updates on closures or modified hours for our UF Health clinical facilities, click here

Full Details
Skip to main content
Update Location

My Location

Update your location to show providers, locations, and services closest to you.

Enter a zip code
Or
Select a campus/region
(352) 733-0111

Macroglossia

Definition

Macroglossia is a disorder in which the tongue is larger than normal.

Information

Macroglossia is most often caused by an increase in the amount of tissue in the tongue, rather than by a growth, such as a tumor.

This condition can be seen in certain inherited or congenital (existing at birth) disorders, including:

  • Acromegaly (buildup of too much growth hormone in the body)
  • Beckwith-Wiedemann syndrome (growth disorder that causes large body size, large organs, and other symptoms)
  • Congenital hypothyroidism (decreased production of thyroid hormone)
  • Diabetes (high blood sugar caused by body producing too little or no insulin)
  • Down syndrome (extra copy of chromosome 21, which causes problems with physical and intellectual functioning)
  • Lymphangioma or hemangioma (malformations in the lymph system or buildup of blood vessels in the skin or internal organs)
  • Mucopolysaccharidoses (a group of diseases that cause large amounts of sugar to build up in the body's cells and tissues)
  • Primary amyloidosis (a buildup of abnormal proteins in the body's tissues and organs)

Gallery

Throat anatomy
Structures of the throat include the esophagus, trachea, epiglottis and tonsils.
Throat anatomy
Structures of the throat include the esophagus, trachea, epiglottis and tonsils.
Throat anatomy
Structures of the throat include the esophagus, trachea, epiglottis and tonsils.

References

Alwani MM, Makki FM, Robbins KT. Physiology of the oral cavity. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 86.

Rose E. Pediatric upper airway obstruction and infections. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 162.

Sankaran S, Kyle P. Abnormalities of the face and neck. In: Coady AM, Bowler S, eds. Twining's Textbook of Fetal Abnormalities. 3rd ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2015:chap 13.

Last reviewed April 28, 2023 by Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team..

Related specialties