At UF Health, we are committed to delivering world-class care for patients diagnosed with pancreatic cancer. Our multidisciplinary approach combines advanced diagnostics, cutting-edge treatments, and personalized care plans tailored to each patient’s unique needs.

As part of the NCI-designated UF Health Cancer Center, we offer more novel clinical trials than any other cancer center in Florida, giving our patients access to groundbreaking therapies and the latest advancements in cancer care.

Why choose UF Health for pancreatic cancer care?

• NCI-Designated Cancer Center: The UF Health Cancer Center is one of only 72 centers in the U.S. designated by the National Cancer Institute. This underscores our commitment to research and excellence in cancer treatment.
• Innovative clinical trials: We offer more novel clinical trials than any other cancer center in Florida. This means our patients have access to new therapies not available elsewhere.
• Advanced surgical expertise: UF Health was among the first to perform the Whipple procedure using the state-of-the-art Da Vinci robotic system. This ensures less invasive and more precise surgical outcomes.
• Multidisciplinary care team: Our team is made up of surgical oncologists, medical oncologists, radiation oncologists, physical therapists and nurse navigators, among other supportive care specialists. These professionals all work together to provide seamless and compassionate care.

Exams and tests for pancreatic cancer

We use imaging tests, lab work and biopsies to diagnose pancreatic cancer. Patients can expect:

• Imaging tests: CT scans, MRI and endoscopic ultrasound to locate pancreatic tumors and determine their spread.
• Blood tests: Including tumor markers like CA 19-9 to help diagnose and monitor the disease.
• Biopsy: A sample of tissue obtained through a needle or during an endoscopic procedure for definitive diagnosis.
• Genetic testing: To identify inherited mutations that may influence treatment options. Every patient with a pancreatic cancer diagnosis receives genetic testing at UF Health.

Pancreatic cancer treatment

Pancreatic cancer treatment often involves a combination of surgery, chemotherapy and radiation therapy. At UF Health, our focus is on delivering the most effective and least invasive treatments, including:

• Minimally invasive surgery: Our surgical oncologists use minimally invasive techniques. This can result in shorter recovery times.
• Whipple procedure: UF Health faculty are pioneers in performing the Whipple procedure. This ensures superior outcomes for eligible patients.
• Targeted therapy and immunotherapy: These treatments offer new avenues of hope for patients with specific genetic markers.
• Clinical trials: Access to innovative therapies through pancreatic cancer research and clinical trials.

Minimally invasive surgical options at UF Health

UF Health’s surgical oncologists are leaders in minimally invasive pancreatic surgeries. Our surgeons utilize the advanced Da Vinci robotic system, a cutting-edge technology enabling:

• Smaller incisions
• Reduced pain and scarring
• Faster recovery times
• Enhanced precision during complex procedures

The Whipple procedure and UF Health’s leadership

The Whipple procedure is a complex surgery often required for pancreatic cancer. UF Health uses the Da Vinci robot to perform the procedure. This ensures minimal disruption to tissues and organs. Robotic surgery is sometimes a safer option for eligible patients.

Pancreatic cancer symptoms

In its early stages, pancreatic cancer often does not show symptoms, which makes it difficult to detect. When symptoms do appear, they may include:

• Jaundice (yellowing of the skin and eyes)
• Abdominal or back pain
• Unexplained weight loss
• Loss of appetite
• Nausea and vomiting
• Fatigue
• New-onset diabetes

Consult a health care provider if you experience any of these symptoms.

Mortality rate and pancreatic cancer stages

The survival rates of pancreatic cancer patients depend on the type and stage of the cancer.

The National Cancer Institute’s SEER database groups cancers into localized, regional and distant stages. Localized relates to cancer that has not spread outside of the pancreas. Regional means the cancer has spread beyond the pancreas to organs or tissue near the pancreas or to the lymph nodes. Distant refers to pancreatic tumors that have spread to other parts of the body not close to the pancreas, which could include the lungs, liver and other sites.

This methodology is used to build a five-year relative survival rate to evaluate the survival of individuals diagnosed with a specific type and stage of pancreatic cancer in comparison to the general population. As an example, a 5-year relative survival rate of 50% for a particular stage of pancreatic cancer indicates that patients with this diagnosis have on average, half the likelihood of surviving at least five years post-diagnosis compared to individuals without the disease.

Localized instances of pancreatic cancer carry a 44% five-year relative survival rate. Regional pancreatic cancer’s five-year relative survival rate is 16%. And the five-year relative survival rate for distant pancreatic cancer is 3%. All SEER stages combined carry a 13% five-year relative survival rate, according to the National Cancer Institute’s Surveillance, Epidemiology, and End Results.

Causes of pancreatic cancer

The exact causes of pancreatic cancer are not fully understood. However, several risk factors have been identified, including:

• Smoking
• Chronic pancreatitis
• Family history of pancreatic cancer
• Obesity
• Diabetes
• Genetic mutations or inherited conditions

Preventing pancreatic cancer

While not all cases can be prevented, adopting a healthy lifestyle can reduce your risk. Steps to lower your chances of developing pancreatic cancer include:

• Quitting smoking
• Maintaining a healthy diet rich in fruits, vegetables, and whole grains
• Exercising regularly
• Limiting alcohol consumption
• Managing chronic conditions like diabetes

Contact UF Health

If you or a loved one has been diagnosed with pancreatic cancer, UF Health is here to help. Learn more about our pancreatic cancer program and schedule a consultation. Contact us today at (352) 265-0725.

Frequently asked questions about pancreatic cancer

How fast does pancreatic cancer spread?

Pancreatic cancer is aggressive nature. Once the disease reaches an advanced stage, it can progress quickly. This rapid advancement contributes to the high mortality rate associated with pancreatic cancer.

How quickly do you deteriorate with pancreatic cancer?

The rate of deterioration in individuals with pancreatic cancer varies. This depends on the cancer's stage at diagnosis, overall health and response to treatment. Patients may experience weight loss, fatigue and pain intensifying over weeks to months. Early detection and prompt treatment are crucial in slowing down the disease’s progression.

Is pancreatic cancer painful?

As the disease advances, pain can become a common symptom of pancreatic cancer. Tumor growth can exert pressure on surrounding nerves and organs. This sometimes leads to abdominal or back pain. Effective pain management strategies can improve comfort and quality of life for patients.

Does alcohol cause pancreatic cancer?

The relationship between alcohol consumption and pancreatic cancer risk is complex. Some studies say that heavy alcohol intake may elevate the risk of pancreatic cancer. However, other research has found no significant association. Alcohol should be consumed in moderation to potentially reduce cancer risk.

Are cases of pancreatic cancer on the rise?

According to the American Cancer Society, incidences of pancreatic cancer are increasing. Aging populations and lifestyle factors help contribute to this. Ongoing research can help us understand these trends. The goal is to develop effective prevention and treatment strategies.

Note: This entry was written by Sean Garrity, UF Health marketing manager, and reviewed for accuracy by Ibrahim Nassour, MD. Generative AI was leveraged as part of the content creation process.