Elias Sayour, MD, PhD

(352) 273-6990

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Publications

The current landscape of immunotherapy for pediatric brain tumors.
Nature cancer
2022

Contemporary RNA Therapeutics for Glioblastoma.
Neuromolecular medicine
2022

CAR T Cell Locomotion in Solid Tumor Microenvironment.
Cells
2022

Optimizing T Cell-Based Therapy for Glioblastoma.
Frontiers in immunology
2021

Nanoparticles as immunomodulators and translational agents in brain tumors.
Journal of neuro-oncology
2021

GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma - assessing tumor and T cell interaction.
Translational oncology
2021

Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate.
Veterinary immunology and immunopathology
2021

Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma.
Cancer research
2020

Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling.
Journal for immunotherapy of cancer
2019

RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors.
Molecular therapy : the journal of the American Society of Gene Therapy
2019

Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition.
Neuro-oncology
2019

Emerging trends in immunotherapy for pediatric sarcomas.
Journal of hematology & oncology
2019

Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging.
ACS nano
2019

Characterization of myeloid-derived suppressor cells and cytokines GM-CSF, IL-10 and MCP-1 in dogs with malignant melanoma receiving a GD3-based immunotherapy.
Veterinary immunology and immunopathology
2019

CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors.
Nature communications
2019

The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas.
Frontiers in molecular neuroscience
2018

Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.
Nano letters
2018

Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.
The EMBO journal
2018

Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes.
International journal of molecular sciences
2018

CD70, a novel target of CAR T-cell therapy for gliomas.
Neuro-oncology
2018

Translational nanoparticle engineering for cancer vaccines.
Oncoimmunology
2017

The effects of new or worsened postoperative neurological deficits on survival of patients with glioblastoma.
Journal of neurosurgery
2017

Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles.
Oncoimmunology
2017

Manipulation of Innate and Adaptive Immunity through Cancer Vaccines.
Journal of immunology research
2017

Immunotherapy for Pediatric Brain Tumors.
Brain sciences
2017

CD4+ and Perivascular Foxp3+ T Cells in Glioma Correlate with Angiogenesis and Tumor Progression.
Frontiers in immunology
2017

FGFR1 N546K and H3F3A K27M mutations in a diffuse leptomeningeal tumour with glial and neuronal markers.
Histopathology
2016

Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
2016

Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia.
Pediatric blood & cancer
2016

Severe adverse immunologic reaction in a patient with glioblastoma receiving autologous dendritic cell vaccines combined with GM-CSF and dose-intensified temozolomide.
Cancer immunology research
2015

Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas.
Oncoimmunology
2015

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma.
Cancer immunology, immunotherapy : CII
2015

Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics.
Journal for immunotherapy of cancer
2015

A novel ELANE gene mutation in a patient with severe congenital neutropenia and intermittent thrombocytopenia.
Pediatric blood & cancer
2015

BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide.
Cancer immunology, immunotherapy : CII
2013

Research Interests