Hemoglobin C disease
Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal.
Clinical hemoglobin C
Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by a problem with a gene called beta globin.
The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.
Exams and Tests
A physical exam may show an enlarged spleen.
Tests that may be done include:
In most cases, no treatment is needed. Folic acid supplements may help your body produce normal red blood cells and improve the symptoms of the anemia.
People with hemoglobin C disease can expect to lead a normal life.
Complications may include:
- Gallbladder disease
- Enlargement of the spleen
When to Contact a Medical Professional
Call your health care provider if you have symptoms of hemoglobin C disease.
You may want to seek genetic counseling if you are at high risk for the condition and are considering having a baby.
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Wilson CS, Vergara-Lluri ME, Brynes RK. Evaluation of anemia, leukopenia, and thrombocytopenia. In: Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, eds. Hematopathology. 2nd ed. Philadelphia, PA: Elsevier; 2017:chap 11.