Jennifer Miller, M.D.

Jennifer L Miller, M.D. - Research & Publications

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Publications

Birth seasonality studies in a large Prader-Willi syndrome cohort
American Journal of Medical Genetics Part a
2019

A multidisciplinary approach to the clinical management of Prader-Willi syndrome
Molecular genetics & genomic medicine
2019

Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome.
Journal of Medical Genetics
2018

Molecular genetic classification in Prader-Willi syndrome: a multisite cohort study.
Journal of Medical Genetics
2018

Elevated plasma oxytocin levels in children with Prader-Willi syndrome compared with healthy unrelated siblings
American Journal of Medical Genetics Part a
2016

Frequency of Prader-Willi syndrome in births conceived via assisted reproductive technology
Genetics in Medicine
2014

An open-label pilot study of N-acetylcysteine for skin-picking in Prader-Willi syndrome
American Journal of Medical Genetics Part a
2014

Prader-Willi Syndrome and Sleep-Disordered Breathing
Pediatric Annals
2013

Unique and Atypical Deletions in Prader-Willi Syndrome Reveal Distinct Phenotypes

2012

Prader-Willi Syndrome

2012

Letter To the Editor: Long-Term Experience With Duodenal Switch in Adolescents
Obesity Surgery
2012

Approach To the Child With Prader-Willi Syndrome
The Journal of Clinical Endocrinology and Metabolism
2012

Nutritional Phases in Prader-Willi Syndrome
American Journal of Medical Genetics Part a
2011

Sleep disordered breathing in infants with Prader-Willi syndrome during the first 6 weeks of growth hormone therapy: a pilot study.
Journal of Clinical Sleep Medicine
2009

Sleep Disordered Breathing in Infants With Prader-Willi Syndrome During the First 6 Weeks of Growth Hormone Therapy: a Pilot Study
Journal of Clinical Sleep Medicine
2009

Early childhood obesity is associated with compromised cerebellar development.
Developmental Neuropsychology
2009

Early Childhood Obesity Is Associated With Compromised Cerebellar Development
Developmental Neuropsychology
2009

"Efficacy of Laparoscopic Sleeve Gastrectomy as a Stand-Alone Technique for Children With Morbid Obesity" and "Bioentericsa (R) Intragastric Balloon for Treatment of Morbid Obesity in Prader-Willi Syndrome: Specific Risks and Benefits(")
Obesity Surgery
2009

Sylvian fissure morphology in Prader-Willi syndrome and early-onset morbid obesity.

2007

Management approaches for pediatric obesity.
Nature Clinical Practice. Endocrinology & Metabolism
2007

Intracranial abnormalities detected by three-dimensional magnetic resonance imaging in Prader-Willi syndrome
American Journal of Medical Genetics Part a
2007

Enhanced activation of reward mediating prefrontal regions in response to food stimuli in Prader-Willi syndrome
Journal of Neurology Neurosurgery and Psychiatry
2007

Short-term effects of growth hormone on sleep abnormalities in Prader-Willi syndrome.
The Journal of Clinical Endocrinology and Metabolism
2006

Central hypothyroidism with oxcarbazepine therapy.
Pediatric Neurology
2006

The management of type 2 diabetes mellitus in children and adolescents
Journal of Pediatric Endocrinology & Metabolism
2005

Research Interests

More than a billion people worldwide are affected by obesity. Over the past 30 years the frequency of overweight in children, defined as a body mass index (BMI) greater than the 85th percentile for age and sex, has tripled. More than 30% of children in the United States are overweight or obese. Data from the International Obesity Task Force indicate that 22 million of the world's children under 5 years of age are overweight or obese. The most devastating statistic, however, is that even the very young are being affected by this epidemic and ndash; almost 12% of infants ages 6 to 23 months are classified as overweight. Determination of the etiology and consequences of childhood obesity is crucial to the understanding and ultimate treatment of this condition.

My research, in collaboration with Daniel Driscoll, PhD, MD, focuses on evaluating the effects of early-onset obesity (i.e. obesity occurring before age 4) on the developing brain. We study 3 groups of individuals and ndash; those with Prader-Willi syndrome (PWS and ndash; a genetic condition known to cause early-onset obesity), those with idiopathic early-onset obesity, and normal weight control siblings from both of those groups. Because PWS can be diagnosed at birth with currently available genetic testing and can be treated with growth hormone to increase muscle mass and decrease fat mass, parents can be given prospective counseling to help them keep the child's weight normal for height through childhood. However, without the appropriate environmental controls instituted by the parents, the natural history of PWS is for children to become obese at 18-36 months of age. Thus, individuals with PWS are an excellent model to discover the effects of early obesity on the brain.

Obesity in adults has been shown to be associated with white matter lesions and brain atrophy on MRI scans. Our group is the first to identify similar brain MRI findings in children and adolescents with early-onset obesity. Currently we are performing brain MRI scans on children over 8 years of age with PWS, early-onset obesity, and their normal weight siblings to identify risk factors and potential causes of these brain abnormalities in children with early-onset obesity. Additional research studies focus on detailing the natural history of both PWS and early-onset morbid obesity, identifying brain satiety response to different sized meals, investigating the effects of early growth hormone treatment in infants with PWS.