Nikolaus McFarland, MD

Nikolaus McFarland, MD, PhD

(352) 274-5400

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Publications

Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons.
Journal of Parkinson's disease
2021

Mild cognitive impairment and dementia in motor manifest Huntington's disease: Classification and prevalence.
Journal of the neurological sciences
2020

Magnetic Resonance Imaging and Neurofilament Light in the Differentiation of Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society
2020

Introducing a Supportive Care Team for Advance Directive Education in a Neurological and Neurosurgical Patient Population.
Journal of patient experience
2020

Early-Motor Phenotype Relates to Neuropsychiatric and Cognitive Disorders in Huntington's Disease.
Movement disorders : official journal of the Movement Disorder Society
2020

Current Management and Emerging Therapies in Multiple System Atrophy.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2020

Automated MRI Classification in Progressive Supranuclear Palsy: A Large International Cohort Study.
Movement disorders : official journal of the Movement Disorder Society
2020

A New MRI Measure to Early Differentiate Progressive Supranuclear Palsy From De Novo Parkinson's Disease in Clinical Practice: An International Study.
Movement disorders : official journal of the Movement Disorder Society
2020

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial.
The Lancet. Neurology
2019

Recognizing and treating atypical Parkinson disorders.
Handbook of clinical neurology
2019

Neurite orientation dispersion and density imaging (NODDI) and free-water imaging in Parkinsonism.
Human brain mapping
2019

Dissecting α-synuclein inclusion pathology diversity in multiple system atrophy: implications for the prion-like transmission hypothesis.
Laboratory investigation; a journal of technical methods and pathology
2019

Development of a transcallosal tractography template and its application to dementia.
NeuroImage
2019

Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study.
The Lancet. Digital health
2019

Development and Validation of the Automated Imaging Differentiation in Parkinsonism (AID-P): A Multi-Site Machine Learning Study.
The Lancet. Digital health
2019

A turn for the worse: Turning performance in Parkinson's disease and Essential tremor.
Clinical biomechanics (Bristol, Avon)
2019

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.
PloS one
2017

Striatal and Hippocampal Atrophy in Idiopathic Parkinson's Disease Patients without Dementia: A Morphometric Analysis.
Frontiers in neurology
2017

Recognizing Atypical Parkinsonisms: "Red Flags" and Therapeutic Approaches.
Seminars in neurology
2017

Progression marker of Parkinson's disease: a 4-year multi-site imaging study.
Brain : a journal of neurology
2017

Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy?
JAMA neurology
2017

Functional activity of the sensorimotor cortex and cerebellum relates to cervical dystonia symptoms.
Human brain mapping
2017

Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study.
Movement disorders : official journal of the Movement Disorder Society
2017

Depressive Symptoms are Frequent in Atypical Parkinsonian Disorders.
Movement disorders clinical practice
2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.
Neurology
2017

The relationship between balance confidence and control in individuals with Parkinson's disease.
Parkinsonism & related disorders
2016

Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes.
Neurology
2016

Free-water imaging in Parkinson's disease and atypical parkinsonism.
Brain : a journal of neurology
2016

Free-water and BOLD imaging changes in Parkinson's disease patients chronically treated with a MAO-B inhibitor.
Human brain mapping
2016

Diagnostic Approach to Atypical Parkinsonian Syndromes.
Continuum (Minneapolis, Minn.)
2016

Weight loss and impact on quality of life in Parkinson's disease.
PloS one
2015

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.
Molecular neurodegeneration
2015

Unexpected dual task benefits on cycling in Parkinson disease and healthy adults: a neuro-behavioral model.
PloS one
2015

Repetitive finger movement performance differs among Parkinson's disease, Progressive Supranuclear Palsy, and spinocerebellar ataxia.
Journal of clinical movement disorders
2015

Global attentional neglect of segmented lines in Parkinson's disease.
Neurocase
2015

Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society
2015

Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy.
Human brain mapping
2015

Discriminating features of gait performance in progressive supranuclear palsy.
Parkinsonism & related disorders
2015

Abnormal tactile pressure perception in Parkinson's disease.
Journal of clinical and experimental neuropsychology
2015

A multi-country Salmonella Enteritidis phage type 14b outbreak associated with eggs from a German producer: 'near real-time' application of whole genome sequencing and food chain investigations, United Kingdom, May to September 2014.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2015

The Exam Starts in the Hallway: Movement Disorders in Geriatric Psychiatry
The American Journal Of Geriatric Psychiatry
2014

The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation.
PloS one
2014

MRI reveals brain abnormalities in drug-naive Parkinson's disease.
Exercise and sport sciences reviews
2014

Driving errors in Parkinson's disease: moving closer to predicting on-road outcomes.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association
2014

Defining the clinically meaningful difference in gait speed in persons with Parkinson disease.
Journal of neurologic physical therapy : JNPT
2014

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.
PloS one
2014

An eight-year clinic experience with clozapine use in a Parkinson's disease clinic setting.
PloS one
2014

Variability in clinical phenotypes of heterozygous and homozygous cases of Parkin-related Parkinson's disease.
The International journal of neuroscience
2013

Valproate as a treatment for dopamine dysregulation syndrome (DDS) in Parkinson's disease.
Journal of neurology
2013

Postural/Gait and cognitive function as predictors of driving performance in Parkinson's disease.
Journal of Parkinson's disease
2013

Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders.
Neuro-degenerative diseases
2013

Movement disorders in 2012: Advancing research towards novel therapeutic approaches.
Nature reviews. Neurology
2013

Efficient determination of purine metabolites in brain tissue and serum by high-performance liquid chromatography with electrochemical and UV detection.
Biomedical chromatography : BMC
2013

Driving performance and behaviors: a comparison of gender differences in Parkinson's disease.
Traffic injury prevention
2013

Direct detection of alpha synuclein oligomers in vivo.
Acta neuropathologica communications
2013

Anti-tau antibodies: hitting the target.
Neuron
2013

Quantitative Normative Gait Data in a Large Cohort of Ambulatory Persons With Parkinson's Disease
PLoS One
2012

Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.
Brain research
2012

Encephalopathy, hypoglycemia, and flailing extremities: a case of bilateral chorea-ballism associated with diabetic ketoacidosis.
Tremor and other hyperkinetic movements (New York, N.Y.)
2012

Deep brain stimulation response in pathologically confirmed cases of multiple system atrophy.
Parkinsonism & related disorders
2012

Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease?
The Journal of neuropsychiatry and clinical neurosciences
2012

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
Nature neuroscience
2011

Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system.
Journal of neurochemistry
2009

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Journal of neuropathology and experimental neurology
2009

Improvement with corticosteroids and azathioprine in GAD65-associated cerebellar ataxia.
Neurology
2006

Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areas.
The Journal of neuroscience : the official journal of the Society for Neuroscience
2002

The place of the thalamus in frontal cortical-basal ganglia circuits.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
2001

Organization of thalamostriatal terminals from the ventral motor nuclei in the macaque.
The Journal of comparative neurology
2001

Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience
2000

Convergent inputs from thalamic motor nuclei and frontal cortical areas to the dorsal striatum in the primate.
The Journal of neuroscience : the official journal of the Society for Neuroscience
2000

The concept of the ventral striatum in nonhuman primates.
Annals of the New York Academy of Sciences
1999

Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate.
The Journal of neuroscience : the official journal of the Society for Neuroscience
1997

Control of islet intercellular adhesion molecule-1 expression by interferon-alpha and hypoxia.
Diabetes
1996

Organization of thalamic projections to the ventral striatum in the primate.
The Journal of comparative neurology
1995

Research Interests

Dr. McFarland is an active member of the Center for Translational Research in Neurodegenerative Disease (CTRND) which aims to bring the bench closer to the bedside. His research focuses on understanding the pathological mechanisms of Parkinson disease and related disorders, and in particular the role of alpha-synuclein in cell toxicity and neurodegeneration. His current studies utilize both cellular and preclinical models to study genes and molecules that may affect brain pathology. A primary goal of his research is to identify and to develop potential novel therapeutics for Parkinson disease and related disorders. His research extends also to the clinic where he is actively involved in multiple clinical trials for atypical Parkinson disorders and Huntington disease.