Delineating Physiologic Mechanisms of Swallowing Impairment and Decline in ALS
Individuals with Amyotrophic Lateral Sclerosis are at high risk for swallowing impairment (dysphagia) which leads to malnutrition, decreased pulmonary health, aspiration and aspiration pneumonia. These sequelae necessitate timely identification of at risk individuals to ensure optimal management of oral intake and pulmonary function. The purpose of this study is to evaluate the discriminant ability of several non-invasive screening tools at detecting swallowing impairment in individuals with ALS.
- Participants enrolled will have the following tests: Videofluoroscopic Swallowing Study (with swallowing analyses performed using the validated scales of DIGEST, Penetration Aspiration Scale, and Normalized Residue Ratio Scale) ; High Resolution Manometry, Voluntary Peak Cough Flow Testing, lingual strength and endurance trials using the Iowa Oral Performance Instrument, reflexive cough testing using a capsaicin challenge and Pulmonary Function Testing.
- In addition, the patient will complete the following surveys: Eating Assessment Tool-10 (EAT-10), Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), and The Center for Neurologic Study Bulbar Function Scale (CNS-BFS).
For more details about study procedures, please contact Kelby Magennis:
- Diagnosis of probable or definite ALS
- Diagnosis within 120 days
Additional inclusion and exclusion criteria apply. Please contact Kelby Magennis:
Can be done from home
KeywordsALS, ALS - resources, Amyotrophic lateral sclerosis, Neurology
Principal InvestigatorEmily Plowman, PhD, CCC-SLP
Begin a new search for other research studies
Studies listed on this site have been approved by a UF Institutional Review Board (IRB), which works to ensure the welfare and rights of research participants as required by federal regulations. Study listings are provided by the UF Clinical and Translational Science Institute in collaboration with UF research teams and the UF IRBs.