Early Markers of Subclinical Pulmonary Vascular Radiation Toxicity in Breast Cancer
Primary purposes:1. Quantify differences in extent of pulmonary vessel radiation damage in breast cancer patients receiving conventional X-ray versus proton RT using serial CT chest scans. Specifically, we will identify differences between the modalities in regards to the lower dose limits for observable vascular changes; the magnitude of effects and dose-response relationship; and the temporal patterns of recovery and vessel regeneration. 2. Quantify differences in temporal patterns of levels of cytokines in the blood in breast cancer patients receiving conventional X-ray versus proton RT using serial blood draws that are time-matched with the CT chest scans. 3. Mathematically model the causal relationship between cytokines levels and vascular damage, and quantify differences between X-ray and proton treatment methodologies in this aspect. The secondary purposes of the study are 1. To monitor long-term (>8 year) incidence of clinical pulmonary toxicity and overall survival in these patients to identify any difference between X-ray and proton treatment methodologies. 2. To identify patterns of asymptomatic metastatic progression in those patients who develop recurrence to the thorax during the follow-up imaging period.
KeywordsBreast Cancer, Radiation Toxicity, CT chest scans, clinical pulmonary toxicity
Principal InvestigatorWalter O'Dell
Sponsoring GroupDepartment of Radiation Oncology
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