Early Markers of Subclinical Pulmonary Vascular Radiation Toxicity in Breast Cancer

Purpose

Primary purposes:1. Quantify differences in extent of pulmonary vessel radiation damage in breast cancer patients receiving conventional X-ray versus proton RT using serial CT chest scans. Specifically, we will identify differences between the modalities in regards to the lower dose limits for observable vascular changes; the magnitude of effects and dose-response relationship; and the temporal patterns of recovery and vessel regeneration. 2. Quantify differences in temporal patterns of levels of cytokines in the blood in breast cancer patients receiving conventional X-ray versus proton RT using serial blood draws that are time-matched with the CT chest scans. 3.    Mathematically model the causal relationship between cytokines levels and vascular damage, and quantify differences between X-ray and proton treatment methodologies in this aspect. The secondary purposes of the study are 1. To monitor long-term (>8 year) incidence of clinical pulmonary toxicity and overall survival in these patients to identify any difference between X-ray and proton treatment methodologies. 2.    To identify patterns of asymptomatic metastatic progression in those patients who develop recurrence to the thorax during the follow-up imaging period.

Keywords

Breast Cancer, Radiation Toxicity, CT chest scans, clinical pulmonary toxicity

Principal Investigator

Walter O'Dell

Sponsoring Group

Department of Radiation Oncology

Contact Information

odelwg@shands.ufl.edu

3522739030


Be an Informed Participant

Before deciding to participate in a research study, take time to learn about clinical research, how it's conducted and your rights as a research participant. Following are some helpful resources from independent sources. Always remember that a clinical research study is research, not treatment.

Know Who to Contact

  • Eligibility: For questions about a specific study and who is eligible to participate, call or email the contact person listed for that study.
  • Your Rights: For questions about your rights as a research participant, contact the UF Institutional Review Boards at 352-273-9600.
  • Feedback: For general questions or feedback about study listings, email the UF Clinical and Translational Science Institute at CTSI-Studies-L@lists.ufl.edu.

Other Resources

  • HealthStreet: Health-focused services, classes and events, and opportunities to participate in research.
  • ResearchMatch.org: Join a national registry of volunteers willing to be contacted about research studies.

For Research Teams