Efficacy, Safety and Mechanism of Action of Lanifibranor (IVA337) in Patients with Type 2 Diabetes (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD)
About two-thirds of people who are overweight, obese, or have type 2 diabetes may accumulate too much fat in their liver, which can cause long term damage that leads to a serious condition called cirrhosis.
The purpose of this study is to learn whether you have too much fat in your liver, and offer a potential treatment if you do.
To learn more about the study and to see if you qualify, fill out the online form here with your contact information or continue scrolling.
Want to reach out to the study team directly? Contact Amanda Slater at Amanda.Slater@medicine.ufl.edu or 352.294.4896.
You can participate if you...
- Are between the ages of 21 – 75 years old
- Are overweight or obese OR
- Have been diagnosed with Type 2 diabetes
Here’s what you’ll be asked to do…
First, the study team will need to confirm whether or not you are eligible to participate in the study.
The study team will then reach out to you and ask you a few questions to see if you are eligible for the next step. If so, you may be asked to come to campus and begin the study and potential treatment.
The entire participation in the study will take about 34 – 36 weeks.
About the treatment
This study is seeking to establish the safety, efficacy and mechanism of action of a drug called Lanifibranor.
The research team believes that treatment with Lanifibranor will significantly decrease fat cells in the liver.
Not everyone in the study will get Lanifibranor, because you will be put into a treatment group by chance (like flipping a coin). As a result, you will either receive Lanifibranor or placebo.
Placebo looks just looks like Lanifibranor and is given in the same way but has no active drug in it. The chance you will get Lanifibranor is 1 out of every 2 patients.
Questions about Lanifibranor? Contact Amanda Slater:
Can be done from home
KeywordsDiabetes, Diabetes - resources, Obesity
Principal InvestigatorKenneth Cusi, MD
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Studies listed on this site have been approved by a UF Institutional Review Board (IRB), which works to ensure the welfare and rights of research participants as required by federal regulations. Study listings are provided by the UF Clinical and Translational Science Institute in collaboration with UF research teams and the UF IRBs.