(HeadStart 4) Newly Diagnosed Children (Less than 10 Years Old) With Medulloblastoma and Other Central Nervous System Primitive Neuro-Ectodermal Tumors: Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with Either Single-Cycle (Low Risk Patients) or Randomization (High Risk Patients) to either Single-Cycle or to Three Tandem Cycles of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue


This research study will compare two different treatment regimens to see which is better for treating children with different types of brain tumors called medulloblastoma and CNS embryonal tumors of the brain or spinal cord.


  • 0 - 10 years old 
  • Disease: Brain tumor
  • Disease type: Medulloblastoma, Central Nervous System Embryonal Tumors

For additional information about eligibility criteria, please contact the study coordinator Jennifer King:


  • Drug: Induction
  • Drug type: Chemotherapy

For additional information about study procedures, please contact the study coordinator Jennifer King:




Brain tumor - children, Central nervous system, Tumor, chemotherapy

Principal Investigator

Sridharan Gururangan



Contact Information



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