Westley Reeves, M.D.

Westley H Reeves, M.D.

(352) 265-4846

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Publications

Reply.
Arthritis & rheumatology (Hoboken, N.J.)
2021

Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus.
Clinical immunology (Orlando, Fla.)
2021

Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
2021

NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus.
Arthritis & rheumatology (Hoboken, N.J.)
2020

Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon.
Arthritis & rheumatology (Hoboken, N.J.)
2020

High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage.
JCI insight
2019

Effects of irisin on the differentiation and browning of human visceral white adipocytes.
American journal of translational research
2019

Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Frontiers in immunology
2018

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Biochemistry
2018

Tubulointerstitial Nephritis in Sjögren Syndrome Treated With Mycophenolate Mofetil.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
2017

Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.)
2017

A Novel Subset of Anti-Inflammatory CD138+ Macrophages Is Deficient in Mice with Experimental Lupus.
Journal of immunology (Baltimore, Md. : 1950)
2017

Sjögren's syndrome-associated microRNAs in CD14(+) monocytes unveils targeted TGFβ signaling.
Arthritis research & therapy
2016

Norovirus antagonism of B-cell antigen presentation results in impaired control of acute infection.
Mucosal immunology
2016

Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren's syndrome.
Journal of immunological methods
2016

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.
American journal of physiology. Endocrinology and metabolism
2016

Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase.
Biochimica et biophysica acta
2016

A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.)
2016

"Lupoid hepatitis" in SLE patients and mice with experimental lupus.
Clinical immunology (Orlando, Fla.)
2016

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.
Journal of immunology (Baltimore, Md. : 1950)
2015

Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.)
2015

Mechanisms of autoantibody production in systemic lupus erythematosus.
Frontiers in immunology
2015

Maintenance of autoantibody production in pristane-induced murine lupus.
Arthritis research & therapy
2015

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts.
PloS one
2015

Animal Models of Interferon Signature Positive Lupus.
Frontiers in immunology
2015

Toll-like receptor 7-stimulated tumor necrosis factor α causes bone marrow damage in systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
2014

Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin.
Clinical immunology (Orlando, Fla.)
2014

Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.
Arthritis research & therapy
2014

Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.
Journal of clinical immunology
2014

Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research & Therapy
2014

Induced murine models of systemic lupus erythematosus.
Methods in molecular biology (Clifton, N.J.)
2014

Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.
Arthritis research & therapy
2014

Editorial: systemic lupus erythematosus: death by fire and ICE?
Arthritis & rheumatology (Hoboken, N.J.)
2014

The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.
Journal of cell science
2013

Regulation of Aberrant Cd4 T Cell Activation By Suppressor of Cytokine Signaling-1 (Socs1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Arthritis and Rheumatism
2013

Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay.
International journal of clinical and experimental pathology
2013

Novel autoantigens in type 1 diabetes.
American journal of translational research
2013

Neutrophil Gelatinase Associated Lipocalin (Ngal/Lipocalin-2) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Arthritis and Rheumatism
2013

Neutrophil Gelatinase Associated Lipocalin (Ngal) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2013

Neutrophil Gelatinase Associated Lipocalin (Ngal) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2013

Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.
Journal of immunology (Baltimore, Md. : 1950)
2013

Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology
2013

Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.
International journal of clinical and experimental pathology
2013

Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism
2013

Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950)
2012

Neutrophil Gelatinase Associated Lipocalin (Ngal) Deficiency Accelerates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology
2012

Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Arthritis and Rheumatism
2012

Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.
Lupus
2012

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?
Arthritis and Rheumatism
2012

Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Blood
2012

Autoantibodies to transcription intermediary factor TIF1β associated with dermatomyositis.
Arthritis research & therapy
2012

Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism
2012

A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
Arthritis and Rheumatism
2012

Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis and Rheumatism
2011

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.
Laboratory investigation; a journal of technical methods and pathology
2011

IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.
Journal of immunology (Baltimore, Md. : 1950)
2011

Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies.
Clinical rheumatology
2011

Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy
2011

Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism
2011

Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy
2011

Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity
2011

Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins.
Arthritis and rheumatism
2011

Atypical clinical presentation of a subset of patients with anti-RNA polymerase III--non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining.
Arthritis research & therapy
2011

Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity.
European journal of immunology
2011

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism
2011

Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes.
Laboratory investigation; a journal of technical methods and pathology
2010

Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy
2010

Monocyte and macrophage abnormalities in systemic lupus erythematosus.
Archivum immunologiae et therapiae experimentalis
2010

Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology
2010

Extraordinary antigenicity of the human Ro52 autoantigen.
American journal of translational research
2010

Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology
2010

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology
2009

Rapid serological detection of autoantibodies associated with Sjögren's syndrome.
Journal of translational medicine
2009

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons.
Trends in immunology
2009

Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades.
Clinical immunology (Orlando, Fla.)
2009

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy
2009

Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology
2009

B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus.
Journal of immunology (Baltimore, Md. : 1950)
2009

Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome.
Frontiers in bioscience (Landmark edition)
2009

Autoantibody To Na14 Is An Independent Marker Primarily for Sjogren's Syndrome
British journal of haematology
2009

Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients
Journal of Allergy and Clinical Immunology
2009

Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients.
Arthritis research & therapy
2008

Tlr-7-Dependent and Fc Gamma R-Independent Production of Type I Interferon in Experimental Murine Lupus
Arthritis and Rheumatism
2008

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus.
The Journal of experimental medicine
2008

Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism
2008

Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Journal of the American Dental Association (1939)
2008

Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Journal of the American Dental Association
2008

Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.
Arthritis and rheumatism
2008

Labial salivary gland biopsies in Sjögren's syndrome: still the gold standard?
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
2008

High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism
2008

Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.
Journal of immunology (Baltimore, Md. : 1950)
2008

Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism
2008

A novel type I IFN-producing cell subset in murine lupus.
Journal of immunology (Baltimore, Md. : 1950)
2008

Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism
2007

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood
2007

Malar rash caused by metal allergy in a patient with systemic lupus erythematosus.
Nature clinical practice. Rheumatology
2007

In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.
Arthritis and rheumatism
2007

Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells.
Nucleic acids research
2007

Deficiency of the type I interferon receptor protects mice from experimental lupus.
Arthritis and rheumatism
2007

Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert review of clinical immunology
2007

Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism
2007

AutoAbSC.Org -- Autoantibody Standardization Committee in 2006.
Autoimmunity reviews
2007

Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis.
Arthritis and rheumatism
2006

Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).
The American journal of pathology
2006

Type I interferon as a target of treatment in SLE.
Endocrine, metabolic & immune disorders drug targets
2006

Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
Vaccine
2006

Role of non-protein amino acid L-canavanine in autoimmunity.
Autoimmunity reviews
2006

Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies.
Arthritis and rheumatism
2006

Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.
Arthritis and rheumatism
2006

International multicenter evaluation of autoantibodies to ribosomal P proteins.
Clinical and vaccine immunology : CVI
2006

Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice.
Toxicology
2006

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
2006

Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody.
Journal of immunological methods
2006

Cutaneous mastocytosis in a patient with primary Sjögren's syndrome.
The Journal of rheumatology
2006

Autoimmune targeting of key components of RNA interference.
Arthritis research & therapy
2006

Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.
Arthritis research & therapy
2006

"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
Arthritis and rheumatism
2006

Pristane-induced autoimmunity in germ-free mice.
Clinical immunology (Orlando, Fla.)
2005

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.
The Journal of experimental medicine
2005

High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus
2005

Effective use of autoantibody tests in the diagnosis of systemic autoimmune disease.
Annals of the New York Academy of Sciences
2005

Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes.
Glia
2005

Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.)
2005

Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism
2004

Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production.
Journal of leukocyte biology
2004

Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome.
Arthritis and rheumatism
2004

Distinctive patterns of autoimmune response induced by different types of mineral oil.
Toxicological sciences : an official journal of the Society of Toxicology
2004

Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting.
Archives of internal medicine
2004

Cutting edge diagnostics in rheumatology: the role of patients, clinicians, and laboratory scientists in optimizing the use of autoimmune serology.
Arthritis and rheumatism
2004

Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2004

Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitro.
The Journal of rheumatology
2004

X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus.
International immunology
2003

Nephritogenic autoantibodies but absence of nephritis in Il-12p35-deficient mice with pristane-induced lupus.
Kidney international
2003

Induction of lupus autoantibodies by adjuvants.
Journal of autoimmunity
2003

Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950)
2003

Henry Kunkel, Stephanie Smith, clinical immunology, and split genes.
Lupus
2003

Ecotropic murine leukemia viruses and exogenous mouse mammary tumor viruses are not essential for pristane-induced lupus.
Arthritis and rheumatism
2003

A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufacturers' laboratories.
The Journal of rheumatology
2003

Effect of an exogenous trigger on the pathogenesis of lupus in (NZB x NZW)F1 mice.
Arthritis and rheumatism
2002

Autoantibodies from an SLE patient immunostain the Barr body.
Cytogenetic and genome research
2002

A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content.
The Journal of rheumatology
2002

Tumor immunity and autoimmunity: a case of Dr. Jekyll and Mr. Hyde.
Clinical immunology (Orlando, Fla.)
2001

Titration emulation: a computer-assisted technique that simplifies the quantification of anti-dsDNA antibodies using the Crithidia luciliae assay.
Lupus
2001

Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane.
Kidney international
2001

Increased prevalence of autoantibodies to ku antigen in African American versus white patients with systemic lupus erythematosus.
Arthritis and rheumatism
2001

Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane.
Clinical and experimental immunology
2000

Induction of hypergammaglobulinemia and macrophage activation by silicone gels and oils in female A.SW mice.
Clinical and diagnostic laboratory immunology
2000

Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus.
Journal of immunology (Baltimore, Md. : 1950)
2000

B cell subsets in pristane-induced autoimmunity.
Current topics in microbiology and immunology
2000

Autoantibodies to DEK oncoprotein in human inflammatory disease.
Arthritis and rheumatism
2000

Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription.
DNA and cell biology
1999

Induction of B cell autoimmunity by pristane.
Current topics in microbiology and immunology
1999

Immunopathogenesis of environmentally induced lupus in mice.
Environmental health perspectives
1999

Disparate T cell requirements of two subsets of lupus-specific autoantibodies in pristane-treated mice.
Clinical and experimental immunology
1999

Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.
The Journal of biological chemistry
1999

Association of terminal deoxynucleotidyl transferase with Ku.
Proceedings of the National Academy of Sciences of the United States of America
1999

Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus.
The Journal of experimental medicine
1998

Influence of microbial stimulation on hypergammaglobulinemia and autoantibody production in pristane-induced lupus.
Clinical immunology and immunopathology
1998

Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding.
The Journal of biological chemistry
1998

Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis.
Arthritis and rheumatism
1998

A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen.
The Journal of biological chemistry
1998

Reference sera for antinuclear antibodies. II. Further definition of antibody specificities in international antinuclear antibody reference sera by immunofluorescence and western blotting.
Arthritis and rheumatism
1997

Recombinant 52 kDa Ro(SSA) ELISA detects autoantibodies in Sjögren's syndrome sera that go undetected by conventional serologic assays.
The Journal of rheumatology
1997

Initiation of autoimmunity to self-proteins complexed with viral antigens.
Annals of the New York Academy of Sciences
1997

Human autoantibodies stabilize the quaternary structure of Ku antigen.
Arthritis and rheumatism
1997

Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the molecular interaction of U1RNP-C protein with the Sm core proteins.
Journal of immunology (Baltimore, Md. : 1950)
1997

p95vav associates with the nuclear protein Ku-70.
Molecular and cellular biology
1996

Late development of anti-La/SS-B antibodies in a patient with Sjogren's syndrome and high titer anti-Ro/SS-A antibodies.
Lupus
1996

Features of autoantigens.
Molecular biology reports
1996

Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.
The Journal of clinical investigation
1996

DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease.
The Journal of biological chemistry
1996

Correlation of antisynthetase antibody levels with disease course in a patient with interstitial lung disease and elevated muscle enzymes.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
1996

Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity.
The Journal of biological chemistry
1996

Autoantibodies to ribosomal P antigens with immune complex glomerulonephritis in SJL mice treated with pristane.
Journal of immunology (Baltimore, Md. : 1950)
1996

Autoantibodies that stabilize the molecular interaction of Ku antigen with DNA-dependent protein kinase catalytic subunit.
Clinical and experimental immunology
1996

Role of free p70 (Ku) subunit in posttranslational stabilization of newly synthesized p80 during DNA-dependent protein kinase assembly.
European journal of cell biology
1995

Pristane induces high titers of anti-Su and anti-nRNP/Sm autoantibodies in BALB/c mice. Quantitation by antigen capture ELISAs based on monospecific human autoimmune sera.
Journal of immunological methods
1995

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.
Proceedings of the National Academy of Sciences of the United States of America
1995

Changing autoantibody profiles with variable clinical manifestations in a patient with relapsing systemic lupus erythematosus and polymyositis.
British journal of rheumatology
1995

Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma.
Lupus
1995

Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane.
Proceedings of the National Academy of Sciences of the United States of America
1995

Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.
The Journal of experimental medicine
1995

Systemic lupus erythematosus. Antibodies to DNA, DNA-binding proteins, and histones.
Rheumatic diseases clinics of North America
1994

Similar DNA binding properties of free P70 (KU) subunit and P70/P80 heterodimer.
FEBS letters
1994

Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy.
The Journal of rheumatology
1994

Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen.
The Journal of experimental medicine
1994

Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane.
The Journal of experimental medicine
1994

Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.
The Journal of clinical investigation
1994

Association of autoantibodies to topoisomerase I and the phosphorylated (IIO) form of RNA polymerase II in Japanese scleroderma patients.
Journal of immunology (Baltimore, Md. : 1950)
1994

Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers.
Journal of cell science
1994

Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.
Molecular biology reports
1993

Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen.
The Journal of experimental medicine
1992

Recognition of multiple epitopes in the coiled-coil domain of lamin B by human autoantibodies.
Molecular immunology
1992

Molecular analysis of autoantibody production.
Concepts in immunopathology
1992

B-cell epitopes of autoantigenic DNA-binding proteins.
Molecular biology reports
1992

Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus.
Rheumatic diseases clinics of North America
1992

Onset and regulation of anti-lamin B autoantibody production is independent of the level of polyclonal activation.
Autoimmunity
1991

Epitopes of the p70 and p80 (Ku) lupus autoantigens.
Journal of immunology (Baltimore, Md. : 1950)
1991

Autoimmune mechanisms in psoriasis.
Seminars in dermatology
1991

Immunopathogenesis of systemic lupus erythematosus and Sjögren's syndrome.
Current opinion in rheumatology
1990

Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species.
Journal of immunology (Baltimore, Md. : 1950)
1990

Role of antigen selectivity in autoimmune responses to the Ku (p70/p80) antigen.
The Journal of clinical investigation
1989

Preferential use of lambda L chain in lamin B autoantibodies.
Journal of immunology (Baltimore, Md. : 1950)
1989

Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.
The Journal of biological chemistry
1989

Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus.
The Journal of clinical investigation
1989

Multiple factors are required for poly(A) addition to a mRNA 3' end.
Genes & development
1988

Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus.
The Journal of experimental medicine
1987

Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody.
The Journal of experimental medicine
1987

Antinuclear antibodies as probes to explore the structural organization of the genome.
The Journal of rheumatology. Supplement
1987

Psoriasis and Raynaud's phenomenon associated with autoantibodies to U1 and U2 small nuclear ribonucleoproteins.
The New England journal of medicine
1986

Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryoglobulins from sera of patients with systemic lupus erythematosus.
The Journal of experimental medicine
1986

Human autoantibodies reactive with the signal-recognition particle.
Proceedings of the National Academy of Sciences of the United States of America
1986

Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera.
The Journal of experimental medicine
1985

Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus.
Arthritis and rheumatism
1985

Small nuclear ribonucleoprotein particle assembly in vivo: demonstration of a 6S RNA-free core precursor and posttranslational modification.
Cell
1985

Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies.
The Journal of clinical investigation
1985

Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies.
Proceedings of the National Academy of Sciences of the United States of America
1984

Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation.
Proceedings of the National Academy of Sciences of the United States of America
1983

The echocardiogram in scleroderma endocarditis of the mitral valve.
Archives of internal medicine
1979

Exacerbation of lupus erythematosus following splenectomy in idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia.
The American journal of medicine
1956

Research Interests

Dr. Reeves' and associates' research focuses on the mechanisms of autoimmunity in systemic autoimmune diseases such as systemic lupus erythematosus (SLE), polymyositis, and Sjogren's syndrome. They have found that the hydrocarbon oil pristane induces a lupus-like syndrome in normal mice characterized by the production of high levels of antinuclear antibodies specific for SLE as well as immune complex-mediated glomerulonephritis and arthritis. Using cytokine knockout mice, they have found that pristane-induced lupus is strongly dependent on IL-6 and interferon-g . The hypothesis that different manifestations of lupus (clinical and serological) result from the overproduction of these and other cytokines is being investigated in patients from the UF Lupus Research Center and in animal models in order to understand the interrelationships between genetic predisposition and environmental triggers of autoimmune disease.