Carl Pepine,

Carl J Pepine, - Research & Publications

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Publications

Gut Microbiota and Serum Metabolite Differences in African Americans and White Americans With High Blood Pressure
International Journal of Cardiology
2018

Maladaptive Left Ventricular Remodeling in Women: An Analysis From the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Study
International Journal of Cardiology
2018

Maladaptive Left Ventricular Remodeling in Women: An Analysis From the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Study
International journal of cardiology
2018

Extent of Coronary Atherosclerosis and Arterial Remodelling in Women: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation
Cardiovascular Diagnosis and Therapy
2018

Unanticipated Cardiotoxicity Associated With Targeted Anticancer Therapy in Patients With Hematologic Malignancies Patients: Natural History and Risk Factors
Cardiovascular Toxicology
2018

Intensive Blood Pressure Lowering Reduces Adverse Cardiovascular Outcomes Among Patients With High-Normal Glucose: An Analysis From the Systolic Blood Pressure Intervention Trial Database
Journal of Clinical Hypertension
2018

Optimal Systolic Blood Pressure Target in Apparent Resistant and Non-Resistant Hypertension: A Pooled Analysis of Patient-Level Data from Sprint and ACCORD.
The American journal of medicine. Supplement
2018

Gut Microbiota and Serum Metabolite Differences in African Americans and White Americans With High Blood Pressure
International journal of cardiology
2018

Rationale and Design of the Seneca (Stem Cell Injection in Cancer Survivors) Trial
American Heart Journal
2018

Genome-wide association analysis of common genetic variants of resistant hypertension.
The Pharmacogenomics Journal
2018

Optimal medical treatment of hypertension in patients with coronary artery disease.
Expert Review of Cardiovascular Therapy
2018

Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study.
International journal of cardiology
2018

Ten-Year Mortality in the Wise Study (Women's Ischemia Syndrome Evaluation)
Circulation-Cardiovascular Quality and Outcomes
2017

Intestinal Permeability Biomarker Zonulin Is Elevated in Healthy Aging
Journal of the American Medical Directors Association
2017

Fifteen New Risk Loci for Coronary Artery Disease Highlight Arterial-Wall-Specific Mechanisms
Nature Genetics
2017

Migraine Headache and Long-Term Cardiovascular Outcomes: An Extended Follow-Up of the Women's Ischemia Syndrome Evaluation
American Journal of Medicine
2017

Aortic Flow Conditions Predict Ejection Efficiency in the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Cardiovascular Diagnosis and Therapy
2017

Systolic blood pressure target: Have we identified the optimal target yet?
Journal of public health and emergency
2017

Identification of Cardiovascular Risk Factors Associated With Bone Marrow Cell Subsets in Patients With Stemi: a Biorepository Evaluation From the Cctrn Time and Latetime Clinical Trials
Basic Research in Cardiology
2017

Use of Bio-Informatics Assessment Schema (Bias) to Improve Diagnosis and Prognosis of Myocardial Perfusion Data: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Cardiovascular Diagnosis and Therapy
2016

Mortality Risk Associated With Resistant Hypertension Among Women: Analysis From Three Prospective Cohorts Encompassing the Spectrum of Women's Heart Disease
Journal of Womens Health
2016

Circulating Progenitor Cells and Coronary Microvascular Dysfunction: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (Wise-Cvd)
Atherosclerosis
2016

Cardiovascular Disease and 10-Year Mortality in Postmenopausal Women With Clinical Features of Polycystic Ovary Syndrome
Journal of Womens Health
2016

Psychosocial Predictors of Long-Term Mortality Among Women With Suspected Myocardial Ischemia: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation
Journal of Behavioral Medicine
2016

Genetic Loci Associated With Nonobstructive Coronary Artery Disease in Caucasian Women
Physiological Genomics
2016

Angina Treatments and Prevention of Cardiac Events: An Appraisal of the Evidence
European Heart Journal Supplements
2015

Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child
Cardiovascular Drugs and Therapy
2015

Gut Dysbiosis Is Linked To Hypertension
Hypertension
2015

Renal Function and Coronary Microvascular Dysfunction in Women With Symptoms/Signs of Ischemia
PLOS One
2015

Efficacy and Safety of Angiotensin Receptor Blockers in Older Patients: a Meta-Analysis of Randomized Trials
American Journal of Hypertension
2015

Effects of Verapamil Sr and Atenolol On 24-Hour Blood Pressure and Heart Rate in Hypertension Patients With Coronary Artery Disease: An International Verapamil Sr-Trandolapril Ambulatory Monitoring Substudy
PLOS One
2015

Cardiac Magnetic Resonance Myocardial Perfusion Reserve Index Is Reduced in Women With Coronary Microvascular Dysfunction a National Heart, Lung, and Blood Institute-Sponsored Study From the Women's Ischemia Syndrome Evaluation
Circulation-Cardiovascular Imaging
2015

Mild Renal Dysfunction and Long-Term Adverse Outcomes in Women With Chest Pain: Results From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2015

Impact of Aspirin According To Type of Stable Coronary Artery Disease: Insights From a Large International Cohort
American Journal of Medicine
2015

Assessing Cardiovascular Risk in Women: Looking Beyond Traditional Risk Factors
Trends in Cardiovascular Medicine
2015

Microvascular Coronary Dysfunction and Ischemic Heart Disease: Where Are We in 2014?
Trends in Cardiovascular Medicine
2015

Aldosterone Inhibition and Coronary Endothelial Function in Women Without Obstructive Coronary Artery Disease: An Ancillary Study of the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation
American Heart Journal
2014

Proceedings From Duke Resistant Hypertension Think Tank
American Heart Journal
2014

Timi Frame Count and Adverse Events in Women With No Obstructive Coronary Disease: a Pilot Study From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
PLOS One
2014

Relationships Between Depression, Dietary Habits, and Cardiovascular Mortality and Events Among Women With Suspected Myocardial Ischemia
Psychosomatic Medicine
2014

A Microvascular-Myocardial Diastolic Dysfunctional State and Risk for Mental Stress Ischemia a Revised Concept of Ischemia During Daily Life
Jacc-Cardiovascular Imaging
2014

Atp2B1 Locus Is Associated With Resistant Hypertension in the International Verapamil Sr Tandolapril Study-Genetic Substudy (Investgenes)
Clinical Pharmacology & Therapeutics
2014

A Pharmacogenomic Genome-Wide Association Study (Gwas) for New Onset Diabetes (Nod) in the International Verapamil Sr-Trandolapril Study (Invest)
Clinical Pharmacology & Therapeutics
2014

A Pharmacogenomic Genome-Wide Association Study for Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study (Invest)
Clinical Pharmacology & Therapeutics
2014

Predictors and Outcomes of Resistant Hypertension Among Patients With Coronary Artery Disease and Hypertension
Journal of Hypertension
2014

Impact of Tcf7L2 Single Nucleotide Polymorphisms On Hydrochlorothiazide-Induced Diabetes
Pharmacogenetics and Genomics
2013

Number and Function of Bone-Marrow Derived Angiogenic Cells and Coronary Flow Reserve in Women Without Obstructive Coronary Artery Disease: a Substudy of the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
PLOS One
2013

Antagonist Molecules in the Treatment of Angina
Expert Opinion on Pharmacotherapy
2013

Enhancing the Function of Cd34(+) Cells By Targeting Plasminogen Activator Inhibitor-1
PLOS One
2013

The Editor's Roundtable: the 10Q Report-Advancing Women's Heart Health Through Improved Research, Diagnosis, and Treatment
American Journal of Cardiology
2013

Association of Kcnj1 Variation With Change in Fasting Glucose and New Onset Diabetes During Hctz Treatment
Pharmacogenomics Journal
2013

Brachial Artery Constriction During Brachial Artery Reactivity Testing Predicts Major Adverse Clinical Outcomes in Women With Suspected Myocardial Ischemia: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Study
PLOS One
2013

A Critical Analysis of Clinical Outcomes Reported in Stem Cell Trials for Acute Myocardial Infarction: Some Thoughts for Design of Future Trials
Current Atherosclerosis Reports
2013

Mortality Implications of Angina and Blood Pressure in Hypertensive Patients With Coronary Artery Disease: New Data From Extended Follow-Up of the International Verapamil/Trandolapril Study (Invest)
Clinical Cardiology
2013

Adverse Outcomes Among Women Presenting With Signs and Symptoms of Ischemia and No Obstructive Coronary Artery Disease: Findings From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Angiographic Core Laboratory
American Heart Journal
2013

Increased Wave Reflection and Ejection Duration in Women With Chest Pain and Nonobstructive Coronary Artery Disease: Ancillary Study From the Women's Ischemia Syndrome Evaluation
Journal of Hypertension
2013

Pharmacogenomic Association of Nonsynonymous Snps in Siglec12, A1Bg, and the Selectin Region and Cardiovascular Outcomes
Hypertension
2013

Body Composition Changes and Cardiometabolic Benefits of a Balanced Italian Mediterranean Diet in Obese Patients With Metabolic Syndrome
Acta Diabetologica
2013

Association of Variants in Nedd4L With Blood Pressure Response and Adverse Cardiovascular Outcomes in Hypertensive Patients Treated With Thiazide Diuretics
Journal of Hypertension
2013

Calcium Antagonists in the Treatment of Coronary Artery Disease
Current Opinion in Pharmacology
2013

Genetic Variation in Pear1 Is Associated With Platelet Aggregation and Cardiovascular Outcomes
Circulation-Cardiovascular Genetics
2013

Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery On Left Ventricular Function After Acute Myocardial Infarction the Time Randomized Trial
Jama-Journal of the American Medical Association
2012

A Degradable, Bioactive, Gelatinized Alginate Hydrogel To Improve Stem Cell/Growth Factor Delivery and Facilitate Healing After Myocardial Infarction
Medical Hypotheses
2012

G Protein Receptor Kinase 4 Polymorphisms Beta-Blocker Pharmacogenetics and Treatment-Related Outcomes in Hypertension
Hypertension
2012

Comparing Marginal Structural Models To Standard Methods for Estimating Treatment Effects of Antihypertensive Combination Therapy
Bmc Medical Research Methodology
2012

Treatment of Hypertension Lower Is Better, Or Is It?
Hypertension
2012

Safety of Coronary Reactivity Testing in Women With No Obstructive Coronary Artery Disease
Jacc-Cardiovascular Interventions
2012

Cell Tracking and the Development of Cell-Based Therapies a View From the Cardiovascular Cell Therapy Research Network
Jacc-Cardiovascular Imaging
2012

Combining Psychosocial Data To Improve Prediction of Cardiovascular Disease Risk Factors and Events: the National Heart, Lung, and Blood Institute-Sponsored Women'S Ischemia Syndrome Evaluation Study
Psychosomatic Medicine
2012

Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells On Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure the Focus-Cctrn Trial
Jama-Journal of the American Medical Association
2012

Non-Synonymous Snps in Sele, Selp, and Siglec12 Associate With Cardiovascular (Cv) Outcomes in the International Verapamil Sr-Trandol-April Study Genetic Substudy (Invest-Genes)
Clinical Pharmacology & Therapeutics
2012

Intracoronary Bone Marrow Mononuclear Cells After Myocardial Infarction Reply
Jama-Journal of the American Medical Association
2012

Cholesteryl Ester Transfer Protein (Cetp) Polymorphisms Affect Mrna Splicing, Hdl Levels, and Sex-Dependent Cardiovascular Risk
PLOS One
2012

Alpha Adducin-1 (Add1)Singlenucleotide Polymorphism (Snp) Associated With New Onset Diabetes Risk With Hydrochlorothiazide (Hctz) Therapy in the International Verapamil Sr Trandolapril Genetic Substudy (Invest-Genes)
Clinical Pharmacology & Therapeutics
2012

Relationships Between Cardiovascular Disease Risk Factors and Depressive Symptoms as Predictors of Cardiovascular Disease Events in Women
Journal of Womens Health
2012

Developing Mechanistic Insights Into Cardiovascular Cell Therapy: Cardiovascular Cell Therapy Research Network Biorepository Core Laboratory Rationale
American Heart Journal
2011

Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 To 3 Weeks Following Acute Myocardial Infarction On Left Ventricular Function the Latetime Randomized Trial
Jama-Journal of the American Medical Association
2011

In Women With Symptoms of Cardiac Ischemia, Nonobstructive Coronary Arteries, and Microvascular Dysfunction, Angiotensin-Converting Enzyme Inhibition Is Associated With Improved Microvascular Function: a Double-Blind Randomized Study From the National Heart, Lung and Blood Institute Women'S Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2011

Timing of Hormone Therapy, Type of Menopause, and Coronary Disease in Women: Data From the National Heart, Lung, and Blood Institute-Sponsored Women'S Ischemia Syndrome Evaluation
Menopause-the Journal of the North American Menopause Society
2011

Response To Letter Regarding Article "Chromosome 9P21 Haplotypes and Prognosis in White and Black Patients With Coronary Artery Disease"
Circulation-Cardiovascular Genetics
2011

Effect of Phosphodiesterase Type 5 Inhibition On Microvascular Coronary Dysfunction in Women: a Women's Ischemia Syndrome Evaluation (Wise) Ancillary Study
Clinical Cardiology
2011

Harmful Effects of Nsaids Among Patients With Hypertension and Coronary Artery Disease
American Journal of Medicine
2011

Quantification of Myocardial Segmental Function in Acute and Chronic Ischemic Heart Disease and Implications for Cardiovascular Cell Therapy Trials a Review From the Nhlbi-Cardiovascular Cell Therapy Research Network
Jacc-Cardiovascular Imaging
2011

Liver X Receptor a Gene Polymorphisms and Variable Cardiovascular Outcomes in Patients Treated With Antihypertensive Therapy: Results From the Invest-Genes Study
Pharmacogenetics and Genomics
2011

Efficacy of Fenofibric Acid Plus Statins On Multiple Lipid Parameters and Its Safety in Women With Mixed Dyslipidemia
American Journal of Cardiology
2011

Kcnj1 Snps Are Associated With Increased Fasting Glucose and Risk of New Onset Diabetes During Hctz Therapy
Clinical Pharmacology & Therapeutics
2011

Genetic Variation in the Calcium Signaling Pathway and Association With Outcomes in Hypertensive Coronary Artery Disease Patients
Clinical Pharmacology & Therapeutics
2011

Chromosome 9p21 Haplotypes and Prognosis in White and Black Patients with Coronary Artery Disease
Circulation-Cardiovascular Genetics
2011

Polymorphisms in Genes Coding for Grk2 and Grk5 and Response Differences in Antihypertensive-Treated Patients
Pharmacogenetics and Genomics
2011

Endothelium as a Predictor of Adverse Outcomes
Clinical Cardiology
2010

An Intravascular Ultrasound Analysis in Women Experiencing Chest Pain in the Absence of Obstructive Coronary Artery Disease: a Substudy From the National Heart, Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Journal of Interventional Cardiology
2010

Aromatase Gene Polymorphisms Are Associated With Survival Among Patients With Cardiovascular Disease in a Sex-Specific Manner
PLOS One
2010

Genetic Variation in the Beta 2 Subunit of the Voltage-Gated Calcium Channel and Pharmacogenetic Association With Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study Genetic Substudy (Invest-Genes)
Circulation-Cardiovascular Genetics
2010

Dhea-S Levels and Cardiovascular Disease Mortality in Postmenopausal Women: Results From the National Institutes of Health-National Heart, Lung, and Blood Institute (Nhlbi)-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
The Journal of Clinical Endocrinology and Metabolism
2010

Combination Rosuvastatin Plus Fenofibric Acid in a Cohort of Patients 65 Years Or Older With Mixed Dyslipidemia: Subanalysis of Two Randomized, Controlled Studies
Clinical Cardiology
2010

Hypertension Control and Cardiovascular Outcomes Among Patients With Diabetes and Coronary Artery Disease Reply
Jama-Journal of the American Medical Association
2010

Prognostic Value of Global Mr Myocardial Perfusion Imaging in Women With Suspected Myocardial Ischemia and No Obstructive Coronary Disease Results From the Nhlbi-Sponsored Wise (Women's Ischemia Syndrome Evaluation) Study
Jacc-Cardiovascular Imaging
2010

Self-Rated Versus Objective Health Indicators as Predictors of Major Cardiovascular Events: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation
Psychosomatic Medicine
2010

Tight Blood Pressure Control and Cardiovascular Outcomes Among Hypertensive Patients With Diabetes and Coronary Artery Disease
Jama-Journal of the American Medical Association
2010

A Randomized Controlled Trial of Low-Dose Hormone Therapy On Myocardial Ischemia in Postmenopausal Women With No Obstructive Coronary Artery Disease: Results From the National Institutes of Health/National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2010

New-Onset Diabetes Risk Associated With Antihypertensive Therapy in Hypertensive Coronary Artery Disease Patients Is Modified By a Single Nucleotide Polymorphism (Snp) in the L-Type Calcium Channel (Ltcc)
Clinical Pharmacology & Therapeutics
2010

Development of a Network To Test Strategies in Cardiovascular Cell Delivery: the Nhlbi-Sponsored Cardiovascular Cell Therapy Research Network (Cctrn)
Journal of Cardiovascular Translational Research
2010

Clinical Association of Variation in the Beta 2 Regulatory Subunit of the Voltage- Gated Calcium Channel ( Cacnb2) With Outcomes in Hypertensive Coronary Artery Disease ( Cad) Patients.
Clinical Pharmacology & Therapeutics
2010

Clinical Association of Variation in the Beta 2 Regulatory Subunit of the Voltage- Gated Calcium Channel (Cacnb2) With Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
Clinical Pharmacology & Therapeutics
2010

Residual Risk for Secondary Ischemic Events in Patients With Atherothrombotic Disease: Opportunity for Future Improvements in Patient Care
Annals of Medicine
2010

Combination rosuvastatin plus fenofibric acid in a cohort of patients 65 years or older with mixed dyslipidemia: subanalysis of two randomized, controlled studies.
Clinical Cardiology
2010

Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST]).
American Journal of Cardiology
2010

Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy.
Hypertension
2010

Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy.
The American journal of medicine. Supplement
2010

The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus beta blockers.
Evidence-Based Medicine
2010

Residual risk for secondary ischemic events in patients with atherothrombotic disease: opportunity for future improvements in patient care.
Annals of Medicine
2010

Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.
Jama-Journal of the American Medical Association
2010

Outcomes Among Hypertensive Patients With Concomitant Peripheral and Coronary Artery Disease Findings From the International Verapamil-Sr/Trandolapril Study
Hypertension
2010

Multicenter Cell Processing for Cardiovascular Regenerative Medicine Applications: the Cardiovascular Cell Therapy Research Network (Cctrn) Experience
Cytotherapy
2010

Systolic Blood Pressure and Subjective Well-Being in Patients With Coronary Artery Disease
Clinical Cardiology
2009

Comorbid Depression and Anxiety Symptoms as Predictors of Cardiovascular Events: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Study
Psychosomatic Medicine
2009

Rationale and Design for Time: a Phase Ii, Randomized, Double-Blind, Placebo-Controlled Pilot Trial Evaluating the Safety and Effect of Timing of Administration of Bone Marrow Mononuclear Cells After Acute Myocardial Infarction
American Heart Journal
2009

Total Estrogen Time and Obstructive Coronary Disease in Women: Insights From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Journal of Womens Health
2009

Cacna1C Gene Polymorphisms, Cardiovascular Disease Outcomes, and Treatment Response
Circulation-Cardiovascular Genetics
2009

Genetic and Pharmacogenetic Associations Between Nos3 Polymorphisms, Blood Pressure, and Cardiovascular Events in Hypertension
American Journal of Hypertension
2009

Importance of Blood Pressure Control in Hypertensive Patients With Coronary Heart Disease in Clinical Practice To Reduce the Risk of Stroke Response
Stroke
2009

Multimarker Approach Predicts Adverse Cardiovascular Events in Women Evaluated for Suspected Ischemia: Results From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation
Clinical Cardiology
2009

The Potential Role of Nitric Oxide in Cardiovascular Safety When Treating Patients With Osteoarthritis and Hypertension: a Moderated Panel Discussion
American Journal of Medicine
2009

The Impact of Nitric Oxide in Cardiovascular Medicine: Untapped Potential Utility
American Journal of Medicine
2009

Adverse Cardiovascular Outcomes in Women With Nonobstructive Coronary Artery Disease a Report From the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project
Archives of Internal Medicine
2009

Efficacy and Safety of Fenofibric Acid in Combination With a Statin in Patients With Mixed Dyslipidemia: Pooled Analysis of Three Phase 3, 12-Week Randomized, Controlled Studies
Journal of Clinical Lipidology
2009

Characteristics and Outcomes of Revascularized Patients With Hypertension An International Verapamil Sr-Trandolapril Substudy
Hypertension
2009

The impact of nitric oxide in cardiovascular medicine: untapped potential utility.
The American journal of medicine. Supplement
2009

Efficacy and Safety of Abt-335 (Fenofibric Acid) in Combination With Simvastatin in Patients With Mixed Dyslipidemia: a Phase 3, Randomized, Controlled Study
American Heart Journal
2009

INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study.
Expert Review of Cardiovascular Therapy
2009

Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus.
Journal of Pediatric Endocrinology & Metabolism
2009

Promoter Polymorphisms in Ace (Angiotensin I-Converting Enzyme) Associated With Clinical Outcomes in Hypertension
Clinical Pharmacology & Therapeutics
2009

Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy.
Hypertension
2009

Pediatric Atorvastatin in Diabetes Trial (Padit): a Pilot Study To Determine the Effect of Atorvastatin On Arterial Stiffness and Endothelial Function in Children With Type 1 Diabetes Mellitus
Journal of Pediatric Endocrinology & Metabolism
2009

Beta-Adrenergic Receptor Gene Polymorphisms and Beta-Blocker Treatment Outcomes in Hypertension
Clinical Pharmacology & Therapeutics
2008

Pulse Pressure and Adverse Outcomes in Women: a Report From the Women'S Ischemia Syndrome Evaluation (Wise)
American Journal of Hypertension
2008

Importance of Socioeconomic Status as a Predictor of Cardiovascular Outcome and Costs of Care in Women With Suspected Myocardial Ischemia. Results From the National Institutes of Health, National Heart, Lung and Blood Institute-Sponsored Women'S Ischemia Syndrome Evaluation (Wise)
Journal of Womens Health
2008

Postmarket Evaluation of Breakthrough Technologies
American Heart Journal
2008

Alpha-Adducin Polymorphism Associated With Increased Risk of Adverse Cardiovascular Outcomes: Results From Genetic Substudy of the International Verapamil Sr-Trandolapril Study (Invest-Genes)
American Heart Journal
2008

Verapamil-Sustained Release-Based Treatment Strategy Is Equivalent To Atenolol-Based Treatment Strategy At Reducing Cardiovascular Events in Patients With Prior Myocardial Infarction: An International Verapamil Sr-Trandolapril (Invest) Substudy
American Heart Journal
2008

Marrow Cell Therapies for Cardiovascular Diseases
Experimental Hematology
2008

Weight Change With Beta-Blocker Use: a Side Effect Put Into Perspective - the Reply
American Journal of Medicine
2008

Response To the J-Point Revisited
Hypertension
2008

Postmenopausal Women With a History of Irregular Menses and Elevated Androgen Measurements At High Risk for Worsening Cardiovascular Event-Free Survival: Results From the National Institutes of Health - National Heart, Lung, and Blood Institute Sponsored Women'S Ischemia Syndrome Evaluation
The Journal of Clinical Endocrinology and Metabolism
2008

Cacnaic Polymorphisms and Cardiovascular Outcomes in the International Verapamil Sr/Trandolapril Study-Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Diabetes Risk Associated With Beta 1-Adrenergic Receptor Polymorphisms Differs By Antihypertensive Drug Therapy: Results From the International Verapamil Sr/Trandolapril Study - Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Madd Variants and Risk of Cardiovascular Events in the International Verapamil Sr/Trandolapril Study - Genetic Substudy (Invest Genes).
Clinical Pharmacology & Therapeutics
2008

Nos3 Polymorphisms Do Not Associate With Adverse Clinical Outcomes in Elderly Hypertensives With Coronaryartery Disease: Analysis of the International Verapamil Sr-Trandolapril Study Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Liver X Receptor-Alpha Gene Variability and Cardiovascular Risk in the International Verapamil Sr/Trandolapril Study - Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Novel Promoter Polymorphisms in Angiotensin-I Converting Enzyme (Ace) Associated With Clinical Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
Clinical Pharmacology & Therapeutics
2008

Clinical and Research Issues Regarding Chronic Advanced Coronary Artery Disease: Part I: Contemporary and Emerging Therapies
American Heart Journal
2008

Predicting Stroke Risk in Hypertensive Patients With Coronary Artery Disease - a Report From the Invest
Stroke
2008

Blood Pressure Targets After High-Risk Myocardial Infarction - Is It Time To Update the Guidelines?
Hypertension
2008

Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) Study.
Journal of Womens Health
2007

Metabolic syndrome and cardiovascular disease: challenges and opportunities.
Clinical Cardiology
2007

The pathophysiology of chronic ischemic heart disease.
Clinical Cardiology
2007

Influence of Hispanic ethnicity on blood pressure control and cardiovascular outcomes in women with CAD and hypertension: findings from INVEST.
Journal of Womens Health
2007

Depressive symptoms in coronary artery disease patients after hypertension treatment.
Annals of Pharmacotherapy
2006

Introduction: there is an important need for increased understanding of the pathophysiology of heart failure postinfarction, new treatment strategies, earlier implementation of effective strategies, and more effective use of existing therapies.
American Journal of Cardiology
2006

An academic-community cardiovascular service line affiliation: design, implementation, and performance.
American Heart Journal
2006

Blood pressure control and cardiovascular outcomes in high-risk Hispanic patients--findings from the International Verapamil SR/Trandolapril Study (INVEST).
American Heart Journal
2006

Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
International Journal of Obesity
2005

Characteristics of contemporary patients with hypertension and coronary artery disease.
Clinical Cardiology
2004

Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women.
Jama-Journal of the American Medical Association
2004

Ischemic heart disease: metabolic approaches to management.
Clinical Cardiology
2004

Introduction: new and emerging implications for the field of vascular biology.
American Journal of Cardiology
2003

Optimizing lipid management in patients with acute coronary syndromes.
American Journal of Cardiology
2003

Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia
American Journal of Cardiology
2001

Sex differences in chest pain in patients with documented coronary artery disease and exercise-induced ischemia: Results from the PIMI study.
American Heart Journal
2001

Enhancing Clinical Trials on the Internet: Lessons from INVEST
Clinical Cardiology
2001

Interventions in cardiology: focus on lipid management in acute and long-term settings.
American Journal of Cardiology
2001

Why vascular biology matters.
American Journal of Cardiology
2001

Angiotensin-converting enzyme inhibitors in patients with atherosclerosis and preserved left ventricular function: clinical outcomes.
Canadian Journal of Cardiology
1998

Endothelial dysfunction and its role in the cycle of cardiovascular disease.
Canadian Journal of Cardiology
1998

Research Interests

Dr. Pepine is an internationally recognized leader in both the clinical and scientific areas of cardiovascular medicine. His major interests focus on the pathophysiology of ischemic heart disease and coronary and systemic vascular hemodynamic mechanisms underlying the disease. He is principal investigator for the UF center for the NHLBI-funded Women's Ischemia Syndrome Evaluation (WISE) and the UF center for the Cardiovascular Cell Therapy Research Network (CCTRN). He has been or is the PI for many investigator initiated clinical trials, as well as NHLBI trials. He is past president of the American College of Cardiology (ACC), the national professional organization for cardiovascular specialists. He currently serves on the Board of Trustees of the ACC and many committees and task forces and is the founder and overall Project Chair for the Vascular Biology Working Group (VBWG).