Carl Pepine, M.D.

Carl J Pepine, M.D. - Research & Publications

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Publications

Efficacy and Safety of Fenofibric Acid in Combination With a Statin in Patients With Mixed Dyslipidemia: Pooled Analysis of Three Phase 3, 12-Week Randomized, Controlled Studies
Journal of Clinical Lipidology
2009

Insulin as a Cardiovascular Therapeutic: Improving Glycemic Control in Patients With Coronary Artery Disease

2009

Effects of intermittent transdermal nitroglycerin on occurrence of ischemia after patch removal: results of the second transdermal intermittent dosing evaluation study (TIDES-II).

1997

Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infarction a Perspective From the Cardiovascular Cell Therapy Research Network

2014

Provoked Coronary Spasm and Acute Coronary Syndromes

2008

Does Angiotensin Plus Aldosterone Inhibition Improve Coronary Endothelial Function? An Ancillary Study From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)

2011

Endothelial dysfunction and its role in the cycle of cardiovascular disease.
Canadian Journal of Cardiology
1998

Ischemic heart disease in women: facts and wishful thinking.

2004

Total Estrogen Time and Obstructive Coronary Disease in Women: Insights From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Journal of Womens Health
2009

Association Between High Endocardial Unipolar Voltage and Improved Left Ventricular Function in Patients With Ischemic Cardiomyopathy

2016

Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 To 3 Weeks Following Acute Myocardial Infarction On Left Ventricular Function the Latetime Randomized Trial
Jama-Journal of the American Medical Association
2011

Mortality Implications of Angina and Blood Pressure in Hypertensive Patients With Coronary Artery Disease: New Data From Extended Follow-Up of the International Verapamil/Trandolapril Study (Invest)
Clinical Cardiology
2013

Prognostic Value of Global Mr Myocardial Perfusion Imaging in Women With Suspected Myocardial Ischemia and No Obstructive Coronary Disease Results From the Nhlbi-Sponsored Wise (Women's Ischemia Syndrome Evaluation) Study
Jacc-Cardiovascular Imaging
2010

A Randomized, Placebo-Controlled Trial of Late Na Current Inhibition (Ranolazine) in Coronary Microvascular Dysfunction (Cmd): Impact on Angina and Myocardial Perfusion Reserve

2016

Mortality Risk Associated With Resistant Hypertension Among Women: Analysis From Three Prospective Cohorts Encompassing the Spectrum of Women's Heart Disease
Journal of Womens Health
2016

Optimizing lipid management in patients with acute coronary syndromes.
American Journal of Cardiology
2003

Efficacy of Fenofibric Acid Plus Statins On Multiple Lipid Parameters and Its Safety in Women With Mixed Dyslipidemia
American Journal of Cardiology
2011

INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study.
Expert Review of Cardiovascular Therapy
2009

Intracoronary Bone Marrow Mononuclear Cells After Myocardial Infarction Reply
Jama-Journal of the American Medical Association
2012

Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells On Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure the Focus-Cctrn Trial
Jama-Journal of the American Medical Association
2012

Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: the year in review.

2010

Angina Treatments and Prevention of Cardiac Events: An Appraisal of the Evidence
European Heart Journal Supplements
2015

Combination rosuvastatin plus fenofibric acid in a cohort of patients 65 years or older with mixed dyslipidemia: subanalysis of two randomized, controlled studies.
Clinical Cardiology
2010

Rationale and Design of the International Verapamil SR/Trandolapril Study (INVEST): An Internet-Based Randomized Trial in Coronary Artery Disease Patients with Hypertension

1998

Lack of Association of the Hmga1 Ivs5-13Insc Variant With Type 2 Diabetes in An Ethnically Diverse Hypertensive Case Control Cohort

2013

Genetic Variation in the Calcium Signaling Pathway and Association With Outcomes in Hypertensive Coronary Artery Disease Patients
Clinical Pharmacology & Therapeutics
2011

In Women With Symptoms of Cardiac Ischemia, Nonobstructive Coronary Arteries, and Microvascular Dysfunction, Angiotensin-Converting Enzyme Inhibition Is Associated With Improved Microvascular Function: a Double-Blind Randomized Study From the National Heart, Lung and Blood Institute Women'S Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2011

Novel Promoter Polymorphisms in Angiotensin-I Converting Enzyme (Ace) Associated With Clinical Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
Clinical Pharmacology & Therapeutics
2008

Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
International Journal of Obesity
2005

Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension.

1998

Blood Pressure Targets After High-Risk Myocardial Infarction - Is It Time To Update the Guidelines?
Hypertension
2008

A Randomized Controlled Trial of Low-Dose Hormone Therapy On Myocardial Ischemia in Postmenopausal Women With No Obstructive Coronary Artery Disease: Results From the National Institutes of Health/National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2010

Increased Wave Reflection and Ejection Duration in Women With Chest Pain and Nonobstructive Coronary Artery Disease: Ancillary Study From the Women's Ischemia Syndrome Evaluation
Journal of Hypertension
2013

Characteristics of contemporary patients with hypertension and coronary artery disease.
Clinical Cardiology
2004

Ten-Year Mortality in the Wise Study (Women's Ischemia Syndrome Evaluation)
Circulation-Cardiovascular Quality and Outcomes
2017

Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy.
Hypertension
2010

Enhancing the Function of Cd34(+) Cells By Targeting Plasminogen Activator Inhibitor-1
PLOS One
2013

Cardiac Magnetic Resonance Myocardial Perfusion Reserve Index Is Reduced in Women With Coronary Microvascular Dysfunction a National Heart, Lung, and Blood Institute-Sponsored Study From the Women's Ischemia Syndrome Evaluation
Circulation-Cardiovascular Imaging
2015

Microvascular Coronary Dysfunction and Ischemic Heart Disease: Where Are We in 2014?
Trends in Cardiovascular Medicine
2015

Association of Variants in Nedd4L With Blood Pressure Response and Adverse Cardiovascular Outcomes in Hypertensive Patients Treated With Thiazide Diuretics
Journal of Hypertension
2013

Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: Results from the Psychophysiological Investigations of Myocardial Ischemia study.

2002

Cacna1C Gene Polymorphisms, Cardiovascular Disease Outcomes, and Treatment Response
Circulation-Cardiovascular Genetics
2009

Intramyocardial, Autologous Cd34+Cell Therapy for Refractory Angina

2011

New-Onset Diabetes Risk Associated With Antihypertensive Therapy in Hypertensive Coronary Artery Disease Patients Is Modified By a Single Nucleotide Polymorphism (Snp) in the L-Type Calcium Channel (Ltcc)
Clinical Pharmacology & Therapeutics
2010

Rationale and Design of the Seneca (Stem Cell Injection in Cancer Survivors) Trial
American Heart Journal
2018

Aromatase Gene Polymorphisms Are Associated With Survival Among Patients With Cardiovascular Disease in a Sex-Specific Manner
PLOS One
2010

Angiotensin-converting enzyme inhibitors in patients with atherosclerosis and preserved left ventricular function: clinical outcomes.
Canadian Journal of Cardiology
1998

Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation.

2008

Interventions in cardiology: focus on lipid management in acute and long-term settings.
American Journal of Cardiology
2001

The pathophysiology of chronic ischemic heart disease.
Clinical Cardiology
2007

Mild Renal Dysfunction and Long-Term Adverse Outcomes in Women With Chest Pain: Results From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
American Heart Journal
2015

Effect of Phosphodiesterase Type 5 Inhibition On Microvascular Coronary Dysfunction in Women: a Women's Ischemia Syndrome Evaluation (Wise) Ancillary Study
Clinical Cardiology
2011

Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST]).
American Journal of Cardiology
2010

Hypertension Control and Cardiovascular Outcomes Among Patients With Diabetes and Coronary Artery Disease Reply
Jama-Journal of the American Medical Association
2010

A Critical Analysis of Clinical Outcomes Reported in Stem Cell Trials for Acute Myocardial Infarction: Some Thoughts for Design of Future Trials
Current Atherosclerosis Reports
2013

Gut Dysbiosis Is Linked To Hypertension
Hypertension
2015

Intensive Blood Pressure Lowering Reduces Adverse Cardiovascular Outcomes Among Patients With High-Normal Glucose: An Analysis From the Systolic Blood Pressure Intervention Trial Database
Journal of Clinical Hypertension
2018

Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child
Cardiovascular Drugs and Therapy
2015

Mortality Associated With Angina and Blood Pressure Control Among Hypertensive Patients With Coronary Artery Disease: New Data From Extended Follow-Up of the International Verapamil/Trandolapril Study

2012

Anxiety Associations With Cardiac Symptoms, Angiographic Disease Severity, and Healthcare Utilization: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation

2013

Alpha-Adducin Polymorphism Associated With Increased Risk of Adverse Cardiovascular Outcomes: Results From Genetic Substudy of the International Verapamil Sr-Trandolapril Study (Invest-Genes)
American Heart Journal
2008

Genetic Loci Associated With Nonobstructive Coronary Artery Disease in Caucasian Women
Physiological Genomics
2016

Cacnaic Polymorphisms and Cardiovascular Outcomes in the International Verapamil Sr/Trandolapril Study-Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Incident Or Continued Angina During Hypertension Treatment Is Associated With Increased Risk of Death, Mi, Or Stroke Among Patients With Known Cad: a Substudy of the International Verapamil/Trandolapril Study (Invest)

2009

The Potential Role of Nitric Oxide in Cardiovascular Safety When Treating Patients With Osteoarthritis and Hypertension: a Moderated Panel Discussion
American Journal of Medicine
2009

A Degradable, Bioactive, Gelatinized Alginate Hydrogel To Improve Stem Cell/Growth Factor Delivery and Facilitate Healing After Myocardial Infarction
Medical Hypotheses
2012

Hypertension Across a Woman's Life Cycle

2018

Madd Variants and Risk of Cardiovascular Events in the International Verapamil Sr/Trandolapril Study - Genetic Substudy (Invest Genes).
Clinical Pharmacology & Therapeutics
2008

Effects of angiotensin-converting enzyme inhibition on transient ischemia: the Quinapril Anti-Ischemia and Symptoms of Angina Reduction (QUASAR) trial.

2003

Treatment-Resistant Blood Pressure Among Patients With Coronary Artery Disease - Cause for Concern: New Data From the Extended Follow-Up of the International Verapamail Sr-Trandolapril Study (Invest)

2012

Effects of Verapamil Sr and Atenolol On 24-Hour Blood Pressure and Heart Rate in Hypertension Patients With Coronary Artery Disease: An International Verapamil Sr-Trandolapril Ambulatory Monitoring Substudy
PLOS One
2015

Impact of Resting Heart Rate On Outcomes in Hypertensive Patients With Coronary Artery Disease: Findings From the International Verapamil-Sr/Trandolapril Study (Invest)

2008

The impact of nitric oxide in cardiovascular medicine: untapped potential utility.
The American journal of medicine. Supplement
2009

Importance of Socioeconomic Status as a Predictor of Cardiovascular Outcome and Costs of Care in Women With Suspected Myocardial Ischemia. Results From the National Institutes of Health, National Heart, Lung and Blood Institute-Sponsored Women'S Ischemia Syndrome Evaluation (Wise)
Journal of Womens Health
2008

Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study.
International journal of cardiology
2018

Psychosocial Predictors of Long-Term Mortality Among Women With Suspected Myocardial Ischemia: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation
Journal of Behavioral Medicine
2016

Electromechanical Assessment of Myocardial Function Is Associated With Improvement in Ejection Fraction in Patients Treated With Autologous Stem Cell Therapy for Ischemic Cardiomyopathy

2013

Polymorphisms in Genes Coding for Grk2 and Grk5 and Response Differences in Antihypertensive-Treated Patients
Pharmacogenetics and Genomics
2011

Bone Marrow Characteristics Associated With Changes in Infarct Size After Stemi a Biorepository Evaluation From the Cctrn Time Trial

2015

Liver X Receptor-Alpha Gene Variability and Cardiovascular Risk in the International Verapamil Sr/Trandolapril Study - Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Detailed Analysis of Polymer Response To Delivery Balloon Expansion of Drug-Eluting Stents Versus Bare Metal Stents

2013

Metabolic syndrome and cardiovascular disease: challenges and opportunities.
Clinical Cardiology
2007

Characteristics and Outcomes of Revascularized Patients With Hypertension An International Verapamil Sr-Trandolapril Substudy
Hypertension
2009

Efficacy and Safety of Angiotensin Receptor Blockers in Older Patients: a Meta-Analysis of Randomized Trials
American Journal of Hypertension
2015

Relationships Between Components of Metabolic Syndrome and Coronary Intravascular Ultrasound (Ivus) Atherosclerosis Measures in Women Without Obstructive Coronary Artery Disease: the Nhlbi-Sponsored Women'S Ischemia Syndrome Evaluation (Wise) Study

2012

The Effect of Timing of Stem Cell Delivery Following Acute Myocardial Infarction: the Nhlbi and Cctrn Time Trial

2012

Rationale and Design of the Concert-Hf Trial (Combination of Mesenchymal and C-Kit(+) Cardiac Stem Cells As Regenerative Therapy for Heart Failure)

2018

An Intravascular Ultrasound Analysis in Women Experiencing Chest Pain in the Absence of Obstructive Coronary Artery Disease: a Substudy From the National Heart, Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Journal of Interventional Cardiology
2010

Optimal Systolic Blood Pressure Target in Apparent Resistant and Non-Resistant Hypertension: A Pooled Analysis of Patient-Level Data from Sprint and ACCORD.
The American journal of medicine. Supplement
2018

Could Retinal Imaging Provide a Simple, Inexpensive, Noninvasive Index for Coronary Microvascular Function in Women With Chest Pain and Nonobstructive Coronary Artery Disease? An Ancillary Pilot Study From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise-Aric)

2011

Nos3 Polymorphisms Do Not Associate With Adverse Clinical Outcomes in Elderly Hypertensives With Coronaryartery Disease: Analysis of the International Verapamil Sr-Trandolapril Study Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Pulse Pressure and Risk of Cardiovascular Outcomes in Patients With Hypertension and Coronary Artery Disease: An International Verapamil Sr-Trandolapril Study (Invest) Analysis

2009

Introduction: new and emerging implications for the field of vascular biology.
American Journal of Cardiology
2003

Systolic Blood Pressure and Subjective Well-Being in Patients With Coronary Artery Disease
Clinical Cardiology
2009

Damage To Polymer Surface and Detachment of Polymer Fragments During Delivery Balloon Expansion of Drug-Eluting Stents: A Previously Unrecognized Source for Adverse Outcomes

2012

Large-Scale Gene-Centric Analysis Identifies Polymorphisms for Resistant Hypertension

2014

Why vascular biology matters.
American Journal of Cardiology
2001

Influence of Hispanic ethnicity on blood pressure control and cardiovascular outcomes in women with CAD and hypertension: findings from INVEST.
Journal of Womens Health
2007

Efficacy and Safety of Abt-335 (Fenofibric Acid) in Combination With Simvastatin in Patients With Mixed Dyslipidemia: a Phase 3, Randomized, Controlled Study
American Heart Journal
2009

2014 Eighth Joint National Committee Panel Recommendation for Blood Pressure Targets Revisited Results From the Invest Study

2014

Importance of Blood Pressure Control in Hypertensive Patients With Coronary Heart Disease in Clinical Practice To Reduce the Risk of Stroke Response
Stroke
2009

Depressive symptoms in coronary artery disease patients after hypertension treatment.
Annals of Pharmacotherapy
2006

Kcnj1 Snps Are Associated With Increased Fasting Glucose and Risk of New Onset Diabetes During Hctz Therapy
Clinical Pharmacology & Therapeutics
2011

Phase II Clinical Research Design in Cardiology Learning the Right Lessons Too Well: Observations and Recommendations From the Cardiovascular Cell Therapy Research Network (Cctrn)

2013

Maladaptive Left Ventricular Remodeling in Women: An Analysis From the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Study
International journal of cardiology
2018

Simple Prediction of Long-Term Mortality Among Hypertensive Patients With Coronary Artery Disease: New Data From An Extended Follow-Up of the International Verapamil-Sr/Trandolapril Study (Invest)

2012

Identification of Cardiovascular Risk Factors Associated With Bone Marrow Cell Subsets in Patients With Stemi: a Biorepository Evaluation From the Cctrn Time and Latetime Clinical Trials
Basic Research in Cardiology
2017

Diabetes Risk Associated With Beta 1-Adrenergic Receptor Polymorphisms Differs By Antihypertensive Drug Therapy: Results From the International Verapamil Sr/Trandolapril Study - Genetic Substudy (Invest-Genes).
Clinical Pharmacology & Therapeutics
2008

Number and Function of Bone-Marrow Derived Angiogenic Cells and Coronary Flow Reserve in Women Without Obstructive Coronary Artery Disease: a Substudy of the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
PLOS One
2013

Differential Effects of Cold Pressor and Acetylcholine During Endothelial Function Assessment in Women With No Obstructive Coronary Artery Disease: the Nhlbi-Sponsored Women'S Ischemia Syndrome Evaluation (Wise) Study

2012

Rethinking Stable Ischemic Heart Disease Is This the Beginning of a New Era?

2012

Cardiovascular Therapies and Associated Glucose Homeostasis Implications Across the Dysglycemia Continuum

2009

Migraine Headache and Long-Term Cardiovascular Outcomes: An Extended Follow-Up of the Women's Ischemia Syndrome Evaluation
American Journal of Medicine
2017

Neuroendocrine activation in heart failure is modified by endurance exercise training.

1999

Unanticipated Cardiotoxicity Associated With Targeted Anticancer Therapy in Patients With Hematologic Malignancies Patients: Natural History and Risk Factors
Cardiovascular Toxicology
2018

An Injectable Capillary-Like Microstructured Alginate Hydrogel Improves Left Ventricular Function After Myocardial Infarction in Rats

2016

Impact of Tcf7L2 Single Nucleotide Polymorphisms On Hydrochlorothiazide-Induced Diabetes
Pharmacogenetics and Genomics
2013

Mild Renal Insufficiency Is An Independent Predictor of Coronary Microvascular Dysfunction Among Women With Symptoms/Signs of Ischemia: a Report From the Women's Ischemia Syndrome Evaluation (Wise)

2013

Timing of Hormone Therapy, Type of Menopause, and Coronary Disease in Women: Data From the National Heart, Lung, and Blood Institute-Sponsored Women'S Ischemia Syndrome Evaluation
Menopause-the Journal of the North American Menopause Society
2011

Identifying Patients At High Risk of a Cardiovascular Event in the Near Future Current Status and Future Directions: Report of a National Heart, Lung, and Blood Institute Working Group

2010

Predictors of adverse outcome among patients with hypertension and coronary artery disease.

2006

Pulse Pressure and Adverse Outcomes in Women: a Report From the Women'S Ischemia Syndrome Evaluation (Wise)
American Journal of Hypertension
2008

Outcomes Among Hypertensive Patients With Concomitant Peripheral and Coronary Artery Disease Findings From the International Verapamil-Sr/Trandolapril Study
Hypertension
2010

Harmful Effects of Nsaids Among Patients With Hypertension and Coronary Artery Disease
American Journal of Medicine
2011

Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy.
Hypertension
2009

Association of Kcnj1 Variation With Change in Fasting Glucose and New Onset Diabetes During Hctz Treatment
Pharmacogenomics Journal
2013

Ischemic heart disease: metabolic approaches to management.
Clinical Cardiology
2004

Postmarket Evaluation of Breakthrough Technologies
American Heart Journal
2008

Clinical Association of Variation in the Beta 2 Regulatory Subunit of the Voltage- Gated Calcium Channel (Cacnb2) With Outcomes in Hypertensive Coronary Artery Disease (Cad) Patients.
Clinical Pharmacology & Therapeutics
2010

Comparison of Low and High Dose Intracoronary Adenosine and Acetylcholine in Women Undergoing Coronary Reactivity Testing: Results From the Nhlbi-Sponsoredwomen's Ischemia Syndrome Evaluation (Wise)

2014

Revisiting the culprit lesion in non-Q-wave myocardial infarction. Results from the VANQWISH trial angiographic core laboratory.

2002

Cholesteryl Ester Transfer Protein (Cetp) Polymorphisms Affect Mrna Splicing, Hdl Levels, and Sex-Dependent Cardiovascular Risk
PLOS One
2012

Comparing Marginal Structural Models To Standard Methods for Estimating Treatment Effects of Antihypertensive Combination Therapy
Bmc Medical Research Methodology
2012

Blood pressure control and cardiovascular outcomes in high-risk Hispanic patients--findings from the International Verapamil SR/Trandolapril Study (INVEST).
American Heart Journal
2006

An Injectable Acellular Capillary Hydrogel Improves Left Ventricular Function After Myocardial Infarction

2012

Prognostic Significance of Evolving St-Segment Depression On Admission and Early Repeat Electrocardiograms in Non-St Elevation Acute Coronary Syndromes - Insights From the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein Ilb/Illa Inhibitor (Synergy) Trial

2008

Coronary Microvascular Reactivity To Adenosine Predicts Adverse Outcome in Women Evaluated for Suspected Ischemia Results From the National Heart, Lung and Blood Institute Wise (Women's Ischemia Syndrome Evaluation) Study

2010

Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy.
The American journal of medicine. Supplement
2010

The Vascular Biology Working Group Twentieth Anniversary

2014

Self-Rated Versus Objective Health Indicators as Predictors of Major Cardiovascular Events: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation
Psychosomatic Medicine
2010

Relationships Between Cardiovascular Disease Risk Factors and Depressive Symptoms as Predictors of Cardiovascular Disease Events in Women
Journal of Womens Health
2012

Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics

2017

Some thoughts on the vasculopathy of women with ischemic heart disease.

2006

Response To the J-Point Revisited
Hypertension
2008

Multiple Causes for Ischemia Without Obstructive Coronary Artery Disease Not a Short List

2015

What Causes Myocardial Infarction in Women Without Obstructive Coronary Artery Disease?

2011

Aldosterone Inhibition and Coronary Endothelial Function in Women Without Obstructive Coronary Artery Disease: An Ancillary Study of the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation
American Heart Journal
2014

Intestinal Permeability Biomarker Zonulin Is Elevated in Healthy Aging
Journal of the American Medical Directors Association
2017

A Pharmacogenomic Genome-Wide Association Study (Gwas) for New Onset Diabetes (Nod) in the International Verapamil Sr-Trandolapril Study (Invest)
Clinical Pharmacology & Therapeutics
2014

Calcium Antagonists in the Treatment of Coronary Artery Disease
Current Opinion in Pharmacology
2013

Chromosome 9p21 Haplotypes and Prognosis in White and Black Patients with Coronary Artery Disease
Circulation-Cardiovascular Genetics
2011

Genetic and Pharmacogenetic Associations Between Nos3 Polymorphisms, Blood Pressure, and Cardiovascular Events in Hypertension
American Journal of Hypertension
2009

Sex differences in chest pain in patients with documented coronary artery disease and exercise-induced ischemia: Results from the PIMI study.
American Heart Journal
2001

Detailed Analysis of Bone Marrow From Patients With Ischemic Heart Disease and Left Ventricular Dysfunction Bm Cd34, Cd11B, and Clonogenic Capacity as Biomarkers for Clinical Outcomes

2014

Daily Activity Measured With Wearable Technology As a Novel Measurement of Treatment Effect in Patients With Coronary Microvascular Dysfunction: Substudy of a Randomized Controlled Crossover Trial

2017

Enhancing Clinical Trials on the Internet: Lessons from INVEST
Clinical Cardiology
2001

Genome-wide association analysis of common genetic variants of resistant hypertension.
The Pharmacogenomics Journal
2018

The use of diuretics plus calcium channel blockers for hypertension may be associated with a higher risk of myocardial infarction but not stroke compared with the combination of diuretics plus beta blockers.
Evidence-Based Medicine
2010

Alpha Adducin-1 (Add1)Singlenucleotide Polymorphism (Snp) Associated With New Onset Diabetes Risk With Hydrochlorothiazide (Hctz) Therapy in the International Verapamil Sr Trandolapril Genetic Substudy (Invest-Genes)
Clinical Pharmacology & Therapeutics
2012

Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery On Left Ventricular Function After Acute Myocardial Infarction the Time Randomized Trial
Jama-Journal of the American Medical Association
2012

Assessing Cardiovascular Risk in Women: Looking Beyond Traditional Risk Factors
Trends in Cardiovascular Medicine
2015

Syndrome X and Microvascular Coronary Dysfunction

2011

Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia
American Journal of Cardiology
2001

Rationale and Design for Time: a Phase Ii, Randomized, Double-Blind, Placebo-Controlled Pilot Trial Evaluating the Safety and Effect of Timing of Administration of Bone Marrow Mononuclear Cells After Acute Myocardial Infarction
American Heart Journal
2009

Clinical and Research Issues Regarding Chronic Advanced Coronary Artery Disease: Part I: Contemporary and Emerging Therapies
American Heart Journal
2008

G Protein Receptor Kinase 4 Polymorphisms Beta-Blocker Pharmacogenetics and Treatment-Related Outcomes in Hypertension
Hypertension
2012

Prognostic Utility of Quantifying Evolutionary St-Segment Depression On Early Follow-Up Electrocardiogram in Patients With Non-St-Segment Elevation Acute Coronary Syndromes

2010

The Editor's Roundtable: the 10Q Report-Advancing Women's Heart Health Through Improved Research, Diagnosis, and Treatment
American Journal of Cardiology
2013

Antagonist Molecules in the Treatment of Angina
Expert Opinion on Pharmacotherapy
2013

Combining Psychosocial Data To Improve Prediction of Cardiovascular Disease Risk Factors and Events: the National Heart, Lung, and Blood Institute-Sponsored Women'S Ischemia Syndrome Evaluation Study
Psychosomatic Medicine
2012

Noninvasive Pressure Waveform Analysis in Women With Chest Pain and Nonobstructive Coronary Artery Disease

2009

Liver X Receptor a Gene Polymorphisms and Variable Cardiovascular Outcomes in Patients Treated With Antihypertensive Therapy: Results From the Invest-Genes Study
Pharmacogenetics and Genomics
2011

Increased Circulating Progenitor Cells in Women With Microvascular Coronary Dysfunction: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (Wise-Cvd)

2013

Dysglycemia During Treatment With Hctz in Patients With Hypertension and Metabolic Syndrome

2008

Development of a Network To Test Strategies in Cardiovascular Cell Delivery: the Nhlbi-Sponsored Cardiovascular Cell Therapy Research Network (Cctrn)
Journal of Cardiovascular Translational Research
2010

Multicenter Cell Processing for Cardiovascular Regenerative Medicine Applications: the Cardiovascular Cell Therapy Research Network (Cctrn) Experience
Cytotherapy
2010

Genetic Variation in Pear1 Is Associated With Platelet Aggregation and Cardiovascular Outcomes
Circulation-Cardiovascular Genetics
2013

Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: the Cctrn Pace Trial (Patients With Intermittent Claudication Injected With ALDH Bright Cells)

2017

Tight Blood Pressure Control and Cardiovascular Outcomes Among Hypertensive Patients With Diabetes and Coronary Artery Disease
Jama-Journal of the American Medical Association
2010

Mild Renal Insufficiency Predicts Mortality and Adverse Events in Women With Cardiac Ischemia, Independent of the Underlying Obstructive Coronary Artery Disease

2013

Circulating Progenitor Cells and Coronary Microvascular Dysfunction: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (Wise-Cvd)
Atherosclerosis
2016

Cardiovascular therapies and associated glucose homeostasis: implications across the dysglycemia continuum.

2009

A Randomized Controlled, Phase 2 Trial of the Viral Serpin Serp-1 in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention

2010

Combination Rosuvastatin Plus Fenofibric Acid in a Cohort of Patients 65 Years Or Older With Mixed Dyslipidemia: Subanalysis of Two Randomized, Controlled Studies
Clinical Cardiology
2010

Pharmacogenomic Association of Nonsynonymous Snps in Siglec12, A1Bg, and the Selectin Region and Cardiovascular Outcomes
Hypertension
2013

Extent of Coronary Atherosclerosis and Arterial Remodelling in Women: the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation
Cardiovascular Diagnosis and Therapy
2018

An academic-community cardiovascular service line affiliation: design, implementation, and performance.
American Heart Journal
2006

Residual Risk for Secondary Ischemic Events in Patients With Atherothrombotic Disease: Opportunity for Future Improvements in Patient Care
Annals of Medicine
2010

Non-Synonymous Snps in Sele, Selp, and Siglec12 Associate With Cardiovascular (Cv) Outcomes in the International Verapamil Sr-Trandol-April Study Genetic Substudy (Invest-Genes)
Clinical Pharmacology & Therapeutics
2012

The role of carnitine in myocardial dysfunction.

2003

Developing Mechanistic Insights Into Cardiovascular Cell Therapy: Cardiovascular Cell Therapy Research Network Biorepository Core Laboratory Rationale
American Heart Journal
2011

Atp2B1 Locus Is Associated With Resistant Hypertension in the International Verapamil Sr Tandolapril Study-Genetic Substudy (Investgenes)
Clinical Pharmacology & Therapeutics
2014

Multimarker Approach Predicts Adverse Cardiovascular Events in Women Evaluated for Suspected Ischemia: Results From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation
Clinical Cardiology
2009

Ischemia and No Obstructive Coronary Artery Disease (Inoca) Developing Evidence-Based Therapies and Research Agenda for the Next Decade

2017

A Microvascular-Myocardial Diastolic Dysfunctional State and Risk for Mental Stress Ischemia a Revised Concept of Ischemia During Daily Life
Jacc-Cardiovascular Imaging
2014

Sudden Cardiac Death and Severity of Obstructive Coronary Artery Disease: a Report From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Study

2009

2014 Hypertension Recommendations From the Eighth Joint National Committee Panel Members Raise Concerns for Elderly Black and Female Populations

2014

Cardiovascular therapies and risk for development of diabetes.

2004

Relationships Between Depression, Dietary Habits, and Cardiovascular Mortality and Events Among Women With Suspected Myocardial Ischemia
Psychosomatic Medicine
2014

Predictors and Outcomes of Resistant Hypertension Among Patients With Coronary Artery Disease and Hypertension
Journal of Hypertension
2014

Promoter Polymorphisms in Ace (Angiotensin I-Converting Enzyme) Associated With Clinical Outcomes in Hypertension
Clinical Pharmacology & Therapeutics
2009

Response To Letter Regarding Article "Chromosome 9P21 Haplotypes and Prognosis in White and Black Patients With Coronary Artery Disease"
Circulation-Cardiovascular Genetics
2011

Cardiovascular and Mortality Risk of Apparent Resistant Hypertension in Women With Suspected Myocardial Ischemia: a Report From the Nhlbi-Sponsored Wise Study

2014

Body Composition Changes and Cardiometabolic Benefits of a Balanced Italian Mediterranean Diet in Obese Patients With Metabolic Syndrome
Acta Diabetologica
2013

Introduction: there is an important need for increased understanding of the pathophysiology of heart failure postinfarction, new treatment strategies, earlier implementation of effective strategies, and more effective use of existing therapies.
American Journal of Cardiology
2006

The Impact of Nitric Oxide in Cardiovascular Medicine: Untapped Potential Utility
American Journal of Medicine
2009

Clinical Association of Variation in the Beta 2 Regulatory Subunit of the Voltage- Gated Calcium Channel ( Cacnb2) With Outcomes in Hypertensive Coronary Artery Disease ( Cad) Patients.
Clinical Pharmacology & Therapeutics
2010

Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus.
Journal of Pediatric Endocrinology & Metabolism
2009

Results From Latetime: a Randomized, Placebo Controlled Trial of Intracoronary Stem Cell Delivery Two To Three Weeks Following Acute Myocardial Infarction

2011

Adverse Cardiovascular Outcomes in Women With Nonobstructive Coronary Artery Disease a Report From the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project
Archives of Internal Medicine
2009

A Pharmacogenomic Genome-Wide Association Study for Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study (Invest)
Clinical Pharmacology & Therapeutics
2014

Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study.

2010

Association Between the Chromosome 9P21 Locus and Angiographic Coronary Artery Disease Burden a Collaborative Meta-Analysis

2013

The Nhlbi Time Trial: One-Year Results

2013

Optimal medical treatment of hypertension in patients with coronary artery disease.
Expert Review of Cardiovascular Therapy
2018

Comorbid Depression and Anxiety Symptoms as Predictors of Cardiovascular Events: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Study
Psychosomatic Medicine
2009

Variable and Decreased Clonogenic Activity of Autologous Bone Marrow in Cell Therapy Patients With Ischemic Heart Disease, and Cd34 as a Biomarker for Clinical Outcomes: Results From the Cardiovascular Cell Therapy Research Network (Cctrn)

2013

Cardiovascular Disease and 10-Year Mortality in Postmenopausal Women With Clinical Features of Polycystic Ovary Syndrome
Journal of Womens Health
2016

Simple Integer Risk Score To Determine Prognosis of Patients With Hypertension and Chronic Stable Coronary Artery Disease

2013

Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) Study.
Journal of Womens Health
2007

Safety of Routine Invasive Versus Selective Invasive Therapy in Women With Non-St-Elevation Acute Coronary Syndrome

2016

Pediatric Atorvastatin in Diabetes Trial (Padit): a Pilot Study To Determine the Effect of Atorvastatin On Arterial Stiffness and Endothelial Function in Children With Type 1 Diabetes Mellitus
Journal of Pediatric Endocrinology & Metabolism
2009

Treatment of Hypertension Lower Is Better, Or Is It?
Hypertension
2012

Beta-Adrenergic Receptor Gene Polymorphisms and Beta-Blocker Treatment Outcomes in Hypertension
Clinical Pharmacology & Therapeutics
2008

Postmenopausal Women With a History of Irregular Menses and Elevated Androgen Measurements At High Risk for Worsening Cardiovascular Event-Free Survival: Results From the National Institutes of Health - National Heart, Lung, and Blood Institute Sponsored Women'S Ischemia Syndrome Evaluation
The Journal of Clinical Endocrinology and Metabolism
2008

Proceedings From Duke Resistant Hypertension Think Tank
American Heart Journal
2014

Impaired coronary vascular reactivity and functional capacity in women: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE) Study.

2006

Genetic Variation in the Beta 2 Subunit of the Voltage-Gated Calcium Channel and Pharmacogenetic Association With Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study Genetic Substudy (Invest-Genes)
Circulation-Cardiovascular Genetics
2010

Weight Change With Beta-Blocker Use: a Side Effect Put Into Perspective - the Reply
American Journal of Medicine
2008

Adverse Outcomes Among Women Presenting With Signs and Symptoms of Ischemia and No Obstructive Coronary Artery Disease: Findings From the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Angiographic Core Laboratory
American Heart Journal
2013

Verapamil-Sustained Release-Based Treatment Strategy Is Equivalent To Atenolol-Based Treatment Strategy At Reducing Cardiovascular Events in Patients With Prior Myocardial Infarction: An International Verapamil Sr-Trandolapril (Invest) Substudy
American Heart Journal
2008

Aortic Flow Conditions Predict Ejection Efficiency in the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Cardiovascular Diagnosis and Therapy
2017

Marrow Cell Therapies for Cardiovascular Diseases
Experimental Hematology
2008

Relationship Between Coronary Micro- and Macrovascular Measures in Women With Chest Pain Without Significant Coronary Artery Disease: An Ancillary Substudy From the Nhbli-Sponsored Women's Ischemia Syndrome Evaluation (Wise)

2011

Electromechanical Assessment of Myocardial Function (Noga) Is Associated With Exercise Improvement in Patients Treated With Autologous Stem Cell Therapy for Refractory Angina

2013

Systolic blood pressure target: Have we identified the optimal target yet?
Journal of public health and emergency
2017

Viral Anti-Inflammatory Treatment of Unstable Coronary Syndromes: the Vt-111 Acute Coronary Syndrome Trial

2009

Oxidative Stress Independently Predicts Diastolic Dysfunction in Women With Signs and Symptoms of Ischemia Without Obstructive Coronary Artery Disease: Results From the Nhlbi-Sponsored Women Ischemia Syndrome Evaluation (Wise)

2013

Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women.
Jama-Journal of the American Medical Association
2004

Long-Term Mortality Associated With New Onset Diabetes in Hypertensive Cad Patients Following Exposure To Antihypertensive Medications: Findings From the International Verapamail Sr-Trandolapril Study (Invest)

2009

Use of Bio-Informatics Assessment Schema (Bias) to Improve Diagnosis and Prognosis of Myocardial Perfusion Data: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
Cardiovascular Diagnosis and Therapy
2016

Adrenergic Gene Polymorphisms and Cardiovascular Risk in the Nhlbi-Sponsored Women'S Ischemia Syndrome Evaluation

2008

Brachial Artery Constriction During Brachial Artery Reactivity Testing Predicts Major Adverse Clinical Outcomes in Women With Suspected Myocardial Ischemia: Results From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise) Study
PLOS One
2013

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction Il-1 Beta- and Il-6-Related Impairment of Bone Marrow Function

2017

Transient Blockade of Tgf-Beta in Hematopoietic Stem Cells and Cd34+Endothelial Precursor Cells Enhances Survival, Proliferation and Reparative Functions in Response To Ischemic Vascular Injury

2009

Predicting Stroke Risk in Hypertensive Patients With Coronary Artery Disease - a Report From the Invest
Stroke
2008

Safety of Coronary Reactivity Testing in Women With No Obstructive Coronary Artery Disease
Jacc-Cardiovascular Interventions
2012

Quantification of Myocardial Segmental Function in Acute and Chronic Ischemic Heart Disease and Implications for Cardiovascular Cell Therapy Trials a Review From the Nhlbi-Cardiovascular Cell Therapy Research Network
Jacc-Cardiovascular Imaging
2011

Endothelium as a Predictor of Adverse Outcomes
Clinical Cardiology
2010

Time From Onset of Acute Anterior Myocardial Infarction Negatively Influences Bone Marrow Cell Function: Preliminary Data From the Nhlbi Cctrn Ancillary Studies

2009

Residual risk for secondary ischemic events in patients with atherothrombotic disease: opportunity for future improvements in patient care.
Annals of Medicine
2010

Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.
Jama-Journal of the American Medical Association
2010

Coronary Angiography Is It Time To Reassess?

2013

Cell Tracking and the Development of Cell-Based Therapies a View From the Cardiovascular Cell Therapy Research Network
Jacc-Cardiovascular Imaging
2012

Gut microbiota and serum metabolite differences in African Americans and White Americans with high blood pressure.
International journal of cardiology
2018

Dhea-S Levels and Cardiovascular Disease Mortality in Postmenopausal Women: Results From the National Institutes of Health-National Heart, Lung, and Blood Institute (Nhlbi)-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
The Journal of Clinical Endocrinology and Metabolism
2010

Timi Frame Count and Adverse Events in Women With No Obstructive Coronary Disease: a Pilot Study From the Nhlbi-Sponsored Women's Ischemia Syndrome Evaluation (Wise)
PLOS One
2014

Blood Pressure Lowering in Patients With Diabetes-One Level Might Not Fit All

2011

Impact of Aspirin According To Type of Stable Coronary Artery Disease: Insights From a Large International Cohort
American Journal of Medicine
2015

Dna Variations in Voltage-Gated Calcium Channel Beta 2 Subunit (Cacnb2) Gene, Functional Consequences, and Association With Adverse Cardiovascular Outcomes in the International Verapamil Sr-Trandolapril Study-Genetic Substudy

2008

Renal Function and Coronary Microvascular Dysfunction in Women With Symptoms/Signs of Ischemia
PLOS One
2015

Fifteen New Risk Loci for Coronary Artery Disease Highlight Arterial-Wall-Specific Mechanisms
Nature Genetics
2017

Research Interests

Dr. Pepine is an internationally recognized leader in both the clinical and scientific areas of cardiovascular medicine. His major interests focus on the pathophysiology of ischemic heart disease and coronary and systemic vascular hemodynamic mechanisms underlying the disease. He is principal investigator for the UF center for the NHLBI-funded Women's Ischemia Syndrome Evaluation (WISE) and the UF center for the Cardiovascular Cell Therapy Research Network (CCTRN). He has been or is the PI for many investigator initiated clinical trials, as well as NHLBI trials. He is past president of the American College of Cardiology (ACC), the national professional organization for cardiovascular specialists. He currently serves on the Board of Trustees of the ACC and many committees and task forces and is the founder and overall Project Chair for the Vascular Biology Working Group (VBWG).