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Definition

Hyperplasia is increased cell production in a normal tissue or organ. Hyperplasia may be a sign of abnormal or precancerous changes. This is called pathologic hyperplasia.

It can also be due to the growth of normal cells. This is called physiologic hyperplasia.

Alternative Names

Hypergenesis

Gallery

Hyperplasia
Hyperplasia is the increased cell production of normal tissue in the body which causes the organ to increase in size.

References

Oakes SA. Cell injury, cell death, and adaptations. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 10th ed. Philadelphia, PA: Elsevier; 2021:chap 2.

Last reviewed July 3, 2025 by Robert Hurd, MD, Professor of Endocrinology and Health Care Ethics, Xavier University, Cincinnati, OH. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team..

Related specialties

Clinical trials: Hyperplasia

UF Health research scientists make medicine better every day. They discover new ways to help people by running clinical trials. When you join a clinical trial, you can get advanced medical care. Sometimes years before it's available everywhere. You can also help make medicine better for everyone else. If you'd like to learn more about clinical trials, visit our clinical trials page. Or click one of the links below:

AVK-101-301

The goal of this clinical trial is to learn if ARD-101 works to treat hyperphagia-related behavior in patients with Prader-Willi syndrome (PWS). It will also teach us about the safety of ARD-101. The main questions it aims to answer are: Does…

Investigator
Jennifer L Miller
Status
Accepting Candidates
Ages
7 Years - N/A
Sexes
All
AVK-101-302

The goal of this clinical trial is to learn if ARD-101 works to treat hyperphagia-related behavior in patients with Prader-Willi syndrome (PWS) when used in a long term setting. It will also teach us about the safety of ARD-101. The main questions…

Investigator
Jennifer L Miller
Status
Accepting Candidates
Ages
13 Years - N/A
Sexes
All

News and patient stories: Hyperplasia

More Hyperplasia stories