Menopause is permanent cessation of menses due to depletion of ovarian follicles.

Natural menopause usually occurs between ages 45 and 55. Many women have no problematic symptoms. Bothersome symptoms may include severe hot flashes, mood and sleep disturbance especially during the first five years following menopause. The lack of estrogen may be associated with a decrease in the thickness and the moisture of the genital tissues leading to urogenital atrophy. This condition may lead to symptoms of vaginal burning, itching, painful intercourse and such. There is also accelerated bone loss with the onset of menopause.