Desmond A Schatz, M.D.

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Publications

The influence of selection bias on identifying an association between allergy medication use and SARS-CoV-2 infection.
EClinicalMedicine
2021

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.
Diabetes
2021

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.
Diabetes
2021

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.
Scientific reports
2021

Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology
2021

Insulin immunotherapy for pretype 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity
2021

Index60 as an additional diagnostic criterion for type 1 diabetes.
Diabetologia
2021

Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics
2021

Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas.
The American journal of pathology
2021

How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?
Diabetes
2021

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.
Diabetes
2021

Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.
Diabetes
2021

An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood.
Diabetes care
2021

A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial.
Lancet (London, England)
2021

Use of Ecological Momentary Assessment to Measure Self-Monitoring of Blood Glucose Adherence in Youth With Type 1 Diabetes.
Diabetes spectrum : a publication of the American Diabetes Association
2020

The Discovery and Structure of Human Insulin.
Pediatric endocrinology reviews : PER
2020

Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
Diabetes
2020

Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials.
Diabetes
2020

Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials.
Diabetes
2020

Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic beta-cells
JCI Insight
2020

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care
2020

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.
Diabetes
2020

Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes.
Nature medicine
2020

Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics
2020

Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic medicine : a journal of the British Diabetic Association
2020

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.
Diabetes care
2020

Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2020

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.
Diabetes technology & therapeutics
2020

An Iterative Process for Identifying Pediatric Patients With Type 1 Diabetes: Retrospective Observational Study.
JMIR medical informatics
2020

Addressing health disparities in type 1 diabetes through peer mentorship.
Pediatric diabetes
2020

The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study
Stress and Health
2019

Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.
Diabetes care
2019

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes.
Nature medicine
2019

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children
Pediatric Diabetes
2019

Objectively Measured Adherence in Adolescents With Type 1 Diabetes on Multiple Daily Injections and Insulin Pump Therapy.
Journal of pediatric psychology
2019

Metabolite-related dietary patterns and the development of islet autoimmunity
Scientific Reports
2019

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.
Diabetes
2019

Is It Time to Prioritize Diabetes Prevention in Practice?
Journal of the American Board of Family Medicine : JABFM
2019

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors.
Diabetes care
2019

Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.
JCI insight
2019

Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics
2019

Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome.
Nature communications
2019

Enhanced Understanding of the Natural History of Pre-Type 1 Diabetes: Fundamental to Prevention.
Pediatric endocrinology reviews : PER
2019

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk
Nutrients
2019

Designing Online and Mobile Diabetes Education for Fathers of Children With Type 1 Diabetes: Mixed Methods Study.
JMIR diabetes
2019

Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.
Diabetes care
2019

Bringing closure: towards achieving a better understanding of Israel.
Lancet (London, England)
2019

Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk
Jama-Journal of the American Medical Association
2019

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.
The New England journal of medicine
2019

Understanding Pre-Type 1 Diabetes: The Key to Prevention.
Frontiers in endocrinology
2018

Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association.
Diabetes care
2018

Transition Education for Young Adults With Type 1 Diabetes: Pilot Feasibility Study for a Group Telehealth Intervention.
JMIR diabetes
2018

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.
Current diabetes reports
2018

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.
Diabetes
2018

Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism
2018

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.
Diabetes care
2018

Immune Intervention for Type 1 Diabetes.
Diabetes technology & therapeutics
2018

Hospital time prior to death and pancreas histopathology: implications for future studies.
Diabetologia
2018

Growth hormone and insulin-like growth factor-I axis in type 1 diabetes.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2018

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific reports
2018

Type 1 diabetes mellitus.
Nature reviews. Disease primers
2017

Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays.
Journal of proteome research
2017

Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care
2017

Poor Adherence to Ketone Testing in Patients With Type 1 Diabetes.
Diabetes care
2017

Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.
Scientific reports
2017

My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety.
Diabetes care
2017

More on Intralymphatic Injection of Autoantigen in Type 1 Diabetes.
The New England journal of medicine
2017

Intake of Energy and Protein is Associated with Overweight Risk at Age 5.5 Years: Results from the Prospective TEDDY Study.
Obesity (Silver Spring, Md.)
2017

Immune Interventions for Type 1 Diabetes Mellitus.
Diabetes technology & therapeutics
2017

High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
Diabetes care
2017

Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas
2017

Erratum. 2016 Presidential Address: Diabetes at 212°-Confronting the Invisible Disease. Diabetes Care 2016;39:1657-1663.
Diabetes care
2017

Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial.
JAMA
2017

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis.
Diabetes
2017

Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.
JAMA pediatrics
2017

Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes.
Pediatric diabetes
2016

Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease.
Clinical and experimental immunology
2016

Type 1 diabetes through two lenses: comparing adolescent and parental perspectives with photovoice.
International journal of pediatric endocrinology
2016

Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production.
Microbiome
2016

The influence of type 1 diabetes on pancreatic weight.
Diabetologia
2016

The DIPP project: 20 years of discovery in type 1 diabetes.
Pediatric diabetes
2016

Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.
Diabetes care
2016

Reevaluation of CMS' Competitive Bidding Program.
Diabetes care
2016

Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care
2016

Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].
Diabetologia
2016

Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.
Clinical and experimental immunology
2016

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes
2016

Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays.
Diabetes
2016

Immune Intervention in Type 1 Diabetes.
Diabetes technology & therapeutics
2016

Identification of tissue-specific cell death using methylation patterns of circulating DNA.
Proceedings of the National Academy of Sciences of the United States of America
2016

Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry.
Pediatric diabetes
2016

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.
Diabetes
2016

Glucagon Nasal Powder: A Promising Alternative to Intramuscular Glucagon in Youth With Type 1 Diabetes.
Diabetes care
2016

Educational Needs and Technological Preferences of Fathers of Youth With Type 1 Diabetes.
The Diabetes educator
2016

Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.
Diabetes care
2016

Current and future efforts toward the prevention of type 1 diabetes.
Pediatric diabetes
2016

Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study.
Scientific reports
2016

Characteristics of youth with type 1 diabetes (T1D) with and without a parent with T1D in the T1D exchange clinic registry.
Journal of diabetes
2016

C-peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry.
Pediatric diabetes
2016

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.
Diabetes
2016

2016 Presidential Address: Diabetes at 212°-Confronting the Invisible Disease.
Diabetes care
2016

Using photography as a method to explore adolescent challenges and resilience in type 1 diabetes.
Diabetes spectrum : a publication of the American Diabetes Association
2015

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study.
Diabetologia
2015

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Diabetes care
2015

Screening for T1D risk to reduce DKA is not economically viable.
Pediatric diabetes
2015

Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.
Diabetes
2015

Rates of diabetic ketoacidosis: international comparison with 49,859 pediatric patients with type 1 diabetes from England, Wales, the U.S., Austria, and Germany.
Diabetes care
2015

Puppy Love, Adolescence, and Chronic Illness: The Importance of Pets for Youth with Type 1 Diabetes.
Journal of patient experience
2015

Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).
Diabetes care
2015

Lowering targets for hemoglobin A1c in children with type 1 diabetes: raising the bar.
Pediatric diabetes
2015

Erratum: Disparities in Social Support for Youths With Type 1 Diabetes. Clinical Diabetes 2015;33:62-69.
Clinical diabetes : a publication of the American Diabetes Association
2015

Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.
Diabetes care
2015

Disparities in social support systems for youths with type 1 diabetes.
Clinical diabetes : a publication of the American Diabetes Association
2015

Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report.
Diabetes care
2015

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes
2015

Body mass index changes in youth in the first year after type 1 diabetes diagnosis.
The Journal of pediatrics
2015

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.
The Journal of clinical investigation
2015

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.
Diabetes
2015

Workplace Checkup: Keeping Patients With Diabetes Employed and Safe on the Job.
Clinical diabetes : a publication of the American Diabetes Association
2014

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes
2014

Pump Use Is Less Frequent in Minority Youth: Transatlantic Analysis in Three Large Registries Representing Austria, Germany, England, Wales and the United States

2014

Insulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy.
Pediatric diabetes
2014

IgG4 antibodies in autoimmune polyglandular disease and IgG4-related endocrinopathies: pathophysiology and clinical characteristics.
Current opinion in pediatrics
2014

Healthcare transition from pediatric to adult medical homes in diabetes mellitus.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2014

HLA similarities indicate shared genetic risk in 21-hydroxylase autoantibody positive South African and United States Addison's disease.
Tissue antigens
2014

Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial.
Pediatric diabetes
2014

Distribution of C-peptide and its determinants in North American children at risk for type 1 diabetes.
Diabetes care
2014

Diabetes and employment.
Diabetes care
2014

Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment.
Diabetes care
2014

Compromised gut microbiota networks in children with anti-islet cell autoimmunity.
Diabetes
2014

Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients.
PloS one
2014

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.
Frontiers in microbiology
2014

B-lymphocyte depletion with rituximab and β-cell function: two-year results.
Diabetes care
2014

A contrast between children and adolescents with excellent and poor control: the T1D Exchange clinic registry experience.
Pediatric diabetes
2014

9β Polymorphism of the glucocorticoid receptor gene appears to have limited impact in patients with Addison's disease.
PloS one
2014

The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients.
Diabetes care
2013

The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.
Journal of autoimmunity
2013

Serological autoantibody profiling of type 1 diabetes by protein arrays.
Journal of proteomics
2013

Salivary cortisol day curves in Addison's disease in patients on hydrocortisone replacement.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
2013

Race, socioeconomic status, and treatment center are associated with insulin pump therapy in youth in the first year following diagnosis of type 1 diabetes.
Diabetes technology & therapeutics
2013

Race and Socioeconomic Status Are Associated With Insulin Pump Therapy in Youth in the First Year Following Diagnosis of Type 1 Diabetes
Diabetes Technology & Therapeutics
2013

Proposal for generating new beta cells in a muted immune environment for type 1 diabetes.
Diabetes/metabolism research and reviews
2013

Investigation of glucocorticoid receptor polymorphisms in relation to metabolic parameters in Addison's disease.
European journal of endocrinology
2013

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials.
Lancet (London, England)
2013

Increased complement activation in human type 1 diabetes pancreata.
Diabetes care
2013

Increased cardiovascular risk in South African patients with Addison's disease.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
2013

Ethnicity influences the diagnosis of primary adrenal insufficiency.
Clinical endocrinology
2013

Diabetes care in the school and day care setting.
Diabetes care
2013

Diabetes and employment.
Diabetes care
2013

Body mass index at the time of diagnosis of autoimmune type 1 diabetes in children.
The Journal of pediatrics
2013

Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
2013

Update on global intervention studies in type 1 diabetes.
Endocrinology and metabolism clinics of North America
2012

Through the fog: recent clinical trials to preserve β-cell function in type 1 diabetes.
Diabetes
2012

The use of leptin as treatment for type 1 diabetes mellitus: counterpoint.
Pediatric diabetes
2012

Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth.
Diabetes care
2012

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews
2012

Diabetes care in the school and day care setting.
Diabetes care
2012

Diabetes and employment.
Diabetes care
2012

Use of a precious resource: parental decision making about using autologous umbilical cord blood in studies involving young children with type 1 diabetes.
Contemporary clinical trials
2011

Toward defining the autoimmune microbiome for type 1 diabetes.
The ISME journal
2011

The pancreas in human type 1 diabetes.
Seminars in immunopathology
2011

Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
Diabetes
2011

Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.
Diabetes
2011

Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial.
Diabetes care
2011

It's time to mow the GRAS in type 1 diabetes.
Diabetes
2011

Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood.
Diabetes care
2011

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.
PloS one
2011

Development of autoantibodies in the TrialNet Natural History Study.
Diabetes care
2011

Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.
Journal of perinatology : official journal of the California Perinatal Association
2011

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.
Lancet (London, England)
2011

Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.
Diabetes care
2011

Autoimmune markers in diabetes.
Clinical chemistry
2011

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial.
Lancet (London, England)
2011

A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants.
Diabetes care
2011

Type I diabetes. Preface.
Endocrinology and metabolism clinics of North America
2010

The Pediatric Diabetes Consortium: Improving Care of Children With Type 1 Diabetes Through Collaborative Research
Diabetes Technology & Therapeutics
2010

Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
PloS one
2010

Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Diabetologia
2010

Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia.
The Journal of clinical endocrinology and metabolism
2010

Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new- onset type 1 diabetes.
Diabetes care
2010

Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications
2010

Estimating the cost of type 1 diabetes in the U.S.: a propensity score matching method.
PloS one
2010

Enhancing the understanding of pre-type 1 diabetes in the general population.
Diabetes care
2010

Efforts to prevent and halt autoimmune beta cell destruction.
Endocrinology and metabolism clinics of North America
2010

Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak?
Journal of pediatric gastroenterology and nutrition
2010

Autoimmunity predominates in a large South African cohort with Addison's disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201.
Clinical endocrinology
2010

Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment.
Diabetes care
2009

The road not taken: a path to curing type 1 diabetes?
European journal of immunology
2009

Seroconversion in the Dpt-1 Study: Evidence of Triggering of Autoimmune Process At Different Ages

2009

Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
The New England journal of medicine
2009

Participant and parent experiences in the oral insulin study of the Diabetes Prevention Trial for Type 1 Diabetes.
Pediatric diabetes
2009

Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1.
Diabetes care
2009

Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia
2009

Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research
2009

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one
2009

Influence of fecal sample storage on bacterial community diversity.
The open microbiology journal
2009

Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes
2009

Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model.
The ISME journal
2009

Challenges in developing endpoints for type 1 diabetes intervention studies.
Diabetes/metabolism research and reviews
2009

Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.
Diabetes care
2009

Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.
JAMA
2009

What's in a name? Thyroid autoimmunity in obese patients with T1D.
Pediatric diabetes
2008

Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy.
The Journal of clinical endocrinology and metabolism
2008

The rosigliazone meta-analysis: lessons for the future.
Diabetes care
2008

The IDS conducts standardization of assays for the measurement of autoantibodies and of T cells in autoimmune diabetes. Preface.
Annals of the New York Academy of Sciences
2008

Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.
Pediatric research
2008

Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes
2008

Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
Clinical and experimental immunology
2008

Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences
2008

Cytokines and type 1 diabetes complications: casual or causal association?
Pediatric diabetes
2008

CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.
Cytokine
2008

Autologous umbilical cord blood infusion for type 1 diabetes.
Experimental hematology
2008

Type 1 diabetes intervention trials 2007: where are we and where are we going?
Current opinion in endocrinology, diabetes, and obesity
2007

Persistence of high health care expenditures among children in Medicaid.
Medical care research and review : MCRR
2007

Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.
Pediatric diabetes
2007

Participant and parent experiences in the parenteral insulin arm of the diabetes prevention trial for type 1 diabetes.
Diabetes care
2007

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
Diabetes
2007

Endocrine complications of childhood cancer therapy: evaluation and management.
Pediatric endocrinology reviews : PER
2007

Comment on: Brugman S et al. (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49:2105-2108.
Diabetologia
2007

Adverse impact of temperature and humidity on blood glucose monitoring reliability: a pilot study.
Diabetes technology & therapeutics
2007

The application of genomic and proteomic technologies in predictive, preventive and personalized medicine.
Vascular pharmacology
2006

Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes.
The Journal of clinical endocrinology and metabolism
2006

Maternal understanding of infant diabetes risk: differential effects of maternal anxiety and depression.
Genetics in medicine : official journal of the American College of Medical Genetics
2006

Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes
2006

Assessing the utility of SELDI-TOF and model averaging for serum proteomic biomarker discovery.
Proteomics
2006

Type 1 diabetes mellitus: etiology, presentation, and management.
Pediatric clinics of North America
2005

The role of leuprolide acetate therapy in triggering auto-immune thyroiditis.
The Journal of pediatrics
2005

Maternal efforts to prevent type 1 diabetes in at-risk children.
Diabetes care
2005

Managed care organization characteristics and outpatient specialty care use among children with chronic illness.
Pediatrics
2005

Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.
Journal of autoimmune diseases
2005

Islet cell autoantibodies: a case of a premature obituary.
Pediatric diabetes
2005

High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial--Type 1 Diabetes.
Diabetologia
2005

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes
2005

Ecological implications of the emergence of non-toxic subcultures from toxic Microcystis strains.
Environmental microbiology
2005

Depressive symptoms in mothers of infants identified as genetically at risk for type 1 diabetes.
Diabetes care
2005

Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of pediatric gastroenterology and nutrition
2005

CD3-antibody therapy in new-onset type 1 diabetes mellitus.
The New England journal of medicine
2005

Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neurology
2005

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus--a new surrogate measure of non-progression?
Pediatric diabetes
2004

Oral insulin therapy to prevent progression of immune-mediated (type 1) diabetes.
Annals of the New York Academy of Sciences
2004

Maternal anxiety associated with newborn genetic screening for type 1 diabetes.
Diabetes care
2004

Islet replacement vs. regeneration: hope or hype?
Pediatric diabetes
2004

Diabetes care in the school and day care setting.
Diabetes care
2004

Diabetes care at diabetes camps.
Diabetes care
2004

Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: case report.
Human reproduction (Oxford, England)
2004

Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes.
Diabetes care
2004

Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination.
Diabetes care
2003

Vaccine therapies for the prevention of type 1 diabetes mellitus.
Paediatric drugs
2003

Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes.
The Journal of clinical endocrinology and metabolism
2003

Prospective assessment in newborns of diabetes autoimmunity (PANDA): maternal understanding of infant diabetes risk.
Genetics in medicine : official journal of the American College of Medical Genetics
2003

Prevention strategies for type 1 diabetes mellitus: current status and future directions.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
2003

Overview of prevention and intervention trials for type 1 diabetes.
Reviews in endocrine & metabolic disorders
2003

Multiple autoantibodies as predictors of Type 1 diabetes in a general population.
Diabetologia
2003

Management of diabetes at diabetes camps.
Diabetes care
2003

Care of children with diabetes in the school and day care setting.
Diabetes care
2003

Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
Pediatric diabetes
2003

Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we?
Annals of the New York Academy of Sciences
2002

Type 1 diabetes islet autoantibody markers.
Diabetes technology & therapeutics
2002

To screen or not to screen for pre-type 1 diabetes?
Hormone research
2002

Prospects for the prevention and reversal of type 1 diabetes mellitus.
Drugs
2002

Generation of islets of Langerhans from adult pancreatic stem cells.
Journal of hepato-biliary-pancreatic surgery
2002

Autoimmune polyglandular syndrome. II: Clinical syndrome and treatment.
Endocrinology and metabolism clinics of North America
2002

Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT).
Journal of pediatric endocrinology & metabolism : JPEM
2001

Proposed guidelines on screening for risk of type 1 diabetes.
Diabetes care
2001

Prediction and prevention of type 1 diabetes.
Current diabetes reports
2001

Pancreatic stem cells: a therapeutic agent that may offer the best approach for curing type 1 diabetes.
Pediatric diabetes
2001

Intervention to delay the onset of diabetes mellitus in very young siblings of children with type 1 diabetes mellitus.
Journal of pediatric endocrinology & metabolism : JPEM
2001

First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes.
The Journal of pediatrics
2001

Therapeutic controversy: prevention and treatment of diabetes in children.
The Journal of clinical endocrinology and metabolism
2000

The relationship of maternal personality characteristics to birth outcomes and infant development.
Birth (Berkeley, Calif.)
2000

Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells.
Nature medicine
2000

Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1.
The Journal of clinical endocrinology and metabolism
2000

Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations.
Pediatric diabetes
2000

The prevention of type I diabetes mellitus.
Pediatric annals
1999

Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives.
Journal of autoimmunity
1999

Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.
Diabetes
1999

Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation
1999

The relationship between humoral and cellular immunity to IA-2 in IDDM.
Diabetes
1998

Patient and family reflections on the use of subcutaneous insulin to prevent diabetes: a retrospective evaluation from a pilot prevention trial.
Journal of diabetes and its complications
1998

Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.
Nature
1998

Cellular immune responses to beta casein: elevated in but not specific for individuals with Type I diabetes mellitus.
Diabetologia
1998

Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation.
Clinical and diagnostic laboratory immunology
1998

A putative HCO3- transporter in the cyanobacterium Synechococcus sp. strain PCC 7942.
FEBS letters
1998

Pharmacological approaches to the prevention of autoimmune diabetes.
Drugs
1997

Prevention of insulin-dependent diabetes mellitus: an overview of three trials.
Cleveland Clinic journal of medicine
1996

Cow's milk and insulin-dependent diabetes mellitus. Innocent until proven guilty.
JAMA
1996

Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism.
The Journal of clinical investigation
1996

Antigen based therapies to prevent diabetes in NOD mice.
Journal of autoimmunity
1996

Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity.
The Journal of clinical endocrinology and metabolism
1996

Testosterone induced priapism in two adolescents with sickle cell disease.
Journal of pediatric endocrinology & metabolism : JPEM
1995

Recent advances in the immunopathogenesis of insulin-dependent diabetes mellitus.
Current opinion in pediatrics
1995

Prevention of insulin-dependent diabetes-1995.
Trends in endocrinology and metabolism: TEM
1995

Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM.
The Journal of clinical endocrinology and metabolism
1995

Accuracy of self-monitoring blood glucose meters in a high humidity, high temperature summer camp setting.
Diabetes care
1995

Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives.
The Journal of clinical investigation
1994

Hypoglycemia in childhood diabetes.
Pediatric annals
1994

High risk HLA-DR/DQ genotypes for IDD confer susceptibility to autoantibodies but DQB1*0602 does not prevent them.
Journal of autoimmunity
1994

Glycemic control in a sample of black and white clinic patients with NIDDM.
Diabetes care
1994

GAD65 autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus.
Journal of autoimmunity
1994

Fatal parathyroid hormone-related protein-induced humoral hypercalcemia of malignancy in a 3-month-old infant.
European journal of pediatrics
1994

Diabetic ketoacidosis in childhood.
Pediatric annals
1994

The genetics of autoimmune diabetes. Approaching a solution to the problem.
American journal of diseases of children (1960)
1993

Permanent diabetes developing after transient neonatal diabetes.
Lancet (London, England)
1993

Intervention therapies for insulin-dependent diabetes.
Autoimmunity
1993

Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: a prospective study in relatives.
The Journal of clinical endocrinology and metabolism
1993

Early diagnosis and specific treatment of insulin-dependent diabetes.
Annals of the New York Academy of Sciences
1993

Autoimmune Addison's disease.
Springer seminars in immunopathology
1993

Antigen-specific immunotherapy: oral tolerance and subcutaneous immunization in the treatment of insulin-dependent diabetes.
Diabetes/metabolism reviews
1993

The pathogenesis, prediction, and prevention of insulin-dependent diabetes mellitus.
Endocrinology and metabolism clinics of North America
1992

Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.
Diabetes care
1992

Human anti-pneumococcal polysaccharide antibodies are secreted by the CD5- B cell lineage.
Cellular immunology
1992

The parental origin of the single X chromosome in Turner syndrome: lack of correlation with parental age or clinical phenotype.
American journal of human genetics
1991

Successful in utero treatment of fetal goiter and hypothyroidism.
The New England journal of medicine
1991

Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion.
Cell
1991

Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes.
Journal of autoimmunity
1991

Defective inducer T-cell function before the onset of insulin-dependent diabetes mellitus.
Journal of autoimmunity
1991

CD5+ B lymphocytes in high-risk islet cell antibody-positive and newly diagnosed IDDM subjects.
Diabetes
1991

Scientific writing courses for pediatrics fellows.
Academic medicine : journal of the Association of American Medical Colleges
1990

Relationship of autoimmunity to thyroid dysfunction in children and adults with Down syndrome.
American journal of medical genetics. Supplement
1990

Minimizing risk of brain herniation during treatment of diabetic ketoacidemia.
The Journal of pediatrics
1990

Comparison of islet autoantibodies in 'pre-diabetes' and recommendations for screening.
Journal of autoimmunity
1990

A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes.
The New England journal of medicine
1990

Natural history of incidental hyperglycemia and glycosuria of childhood.
The Journal of pediatrics
1989

Long-term immunoregulatory effects of therapy with corticosteroids and anti-thymocyte globulin.
Immunopharmacology and immunotoxicology
1989

Initial pathogenic events in IDDM.
Diabetes
1989

Polyclonal nature of islet cell antibodies in insulin-dependent diabetes.
Autoimmunity
1988

Lymphocyte subsets in pre-diabetes.
Advances in experimental medicine and biology
1988

Evolution of the subclass of IgG antibody to type 3 pneumococcal polysaccharide during childhood.
Clinical and experimental immunology
1987

Research Interests

Up to 3 million Americans are stricken with type 1 diabetes, but the epidemic spans the globe and is rapidly worsening. The frequency of the disease has already soared five-fold in the past 50 years alone, and the costs to human health come into sharp focus. Diabetes is one of six leading causes of death in the United States, and the No. 1 cause of acquired blindness, kidney failure and non-traumatic amputation. It also fuels cardiovascular disease, the nation's No. 1 killer, and accounts for more than $174 billion in health-care expenditures, with type 1 diabetes accounting for a disproportionate share of those costs. Dr Schatz' research has focused on the prediction, natural history, genetics, immunopathogenesis and prevention of Type 1 diabetes, as well as the management of children and adolescents with Type 1 diabetes.

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