Desmond A Schatz, M.D.

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Publications

The Discovery and Structure of Human Insulin
Pediatric endocrinology reviews : PER
2020

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
Diabetes Care
2019

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors
Diabetes Care
2019

Enhanced Understanding of the Natural History of Pre-Type 1 Diabetes: Fundamental to Prevention
Pediatric endocrinology reviews : PER
2019

Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range
Diabetes Care
2019

Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association.
Diabetes Care
2018

Transition Education for Young Adults With Type 1 Diabetes: Pilot Feasibility Study for a Group Telehealth Intervention
JMIR Diabetes
2018

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-the Trialnet Experience
Diabetes
2018

Objectively Measured Adherence in Adolescents With Type 1 Diabetes on Multiple Daily Injections and Insulin Pump Therapy.
Journal of Pediatric Psychology
2018

Immune Intervention for Type 1 Diabetes
Diabetes Technology & Therapeutics
2018

Hospital Time Prior to Death and Pancreas Histopathology: Implications for Future Studies

2018

Growth hormone and insulin-like growth factor-I axis in type 1 diabetes
Growth Hormone & Igf Research
2018

Type 1 Diabetes Mellitus
Nature Reviews Disease Primers
2017

Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays
Journal of Proteome Research
2017

Plant-Based Vaccines for Oral Delivery of Type 1 Diabetes-Related Autoantigens: Evaluating Oral Tolerance Mechanisms and Disease Prevention in Nod Mice
Scientific Reports
2017

My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety
Diabetes Care
2017

Intake of Energy and Protein Is Associated With Overweight Risk at Age 5.5 Years: Results From the Prospective Teddy Study
Obesity
2017

Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity
Jama Pediatrics
2017

Vitamin D Status in Youth With Type 1 and Type 2 Diabetes Enrolled in the Pediatric Diabetes Consortium (Pdc) Is Not Worse Than in Youth Without Diabetes

2016

The Influence of Type 1 Diabetes on Pancreatic Weight

2016

Insulitis and -Cell Mass in the Natural History of Type 1 Diabetes
Diabetes
2016

Immune Intervention in Type 1 Diabetes
Diabetes Technology & Therapeutics
2016

Identification of Tissue-Specific Cell Death Using Methylation Patterns of Circulating DNa
Proceedings of the National Academy of Sciences of the United States of America
2016

Hla-Drb1{*}15:01-Dqa1{*}01:02-Dqb1{*}06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression
Diabetes
2016

Hemoglobin A1C (Hba1C) Changes Over Time Among Adolescent and Young Adult Participants in the T1D Exchange Clinic Registry

2016

Glucagon Nasal Powder: a Promising Alternative to Intramuscular Glucagon in Youth With Type 1 Diabetes
Diabetes Care
2016

Complement Gene Variants in Relation to Autoantibodies to Beta Cell Specific Antigens and Type 1 Diabetes in the Teddy Study
Scientific Reports
2016

Characteristics of Youth With Type 1 Diabetes (T1D) With and Without a Parent With T1D in the T1D Exchange Clinic Registry
Journal of Diabetes
2016

C-Peptide Levels in Pediatric Type 2 Diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry

2016

Antithymocyte Globulin Plus G-Csf Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes
Diabetes
2016

2016 Presidential Address: Diabetes at 212 Degrees-Confronting the Invisible Disease
Diabetes Care
2016

The 6 Year Incidence of Diabetes-Associated Autoantibodies in Genetically At-Risk Children: the Teddy Study

2015

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association
Diabetes Care
2015

Screening for T1D Risk to Reduce Dka Is Not Economically Viable

2015

Role of Type 1 Diabetes-Associated Snps On Risk of Autoantibody Positivity in the Teddy Study
Diabetes
2015

Puppy Love, Adolescence, and Chronic Illness: The Importance of Pets for Youth with Type 1 Diabetes
Journal of patient experience (Print)
2015

Predictors of Progression From the Appearance of Islet Autoantibodies To Early Childhood Diabetes: the Environmental Determinants of Diabetes in the Young (Teddy)
Diabetes Care
2015

Lowering Targets for Hemoglobin A1C in Children With Type 1 Diabetes: Raising the Bar

2015

Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects At High Risk for Type 1 Diabetes
Diabetes Care
2015

Disparities in social support systems for youths with type 1 diabetes
Clinical diabetes
2015

Body Mass Index Changes in Youth in the First Year After Type 1 Diabetes Diagnosis
Journal of Pediatrics
2015

Anti-Thymocyte Globulin/G-Csf Treatment Preserves Beta Cell Function in Patients With Established Type 1 Diabetes
Journal of Clinical Investigation
2015

Acute Versus Progressive Onset of Diabetes in Nod Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes
Diabetes
2015

Pump Use Is Less Frequent in Minority Youth: Transatlantic Analysis in Three Large Registries Representing Austria, Germany, England, Wales and the United States

2014

Insulin Pump Use in Young Children in the T1D Exchange Clinic Registry Is Associated With Lower Hemoglobin A1C Levels Than Injection Therapy

2014

Igg4 Antibodies in Autoimmune Polyglandular Disease and Igg4-Related Endocrinopathies: Pathophysiology and Clinical Characteristics
Current Opinion in Pediatrics
2014

Hla Similarities Indicate Shared Genetic Risk in 21-Hydroxylase Autoantibody Positive South African and United States Addison's Disease
Tissue Antigens
2014

Healthcare transition from pediatric to adult medical homes in diabetes mellitus
Endocrine Practice
2014

Effect of a Single Autologous Cord Blood Infusion On Beta-Cell and Immune Function in Children With New Onset Type 1 Diabetes: a Non-Randomized, Controlled Trial

2014

Compromised gut microbiota networks in children with anti-islet cell autoimmunity
Diabetes
2014

Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients
PLoS One
2014

Bacteroides Dorei Dominates Gut Microbiome Prior To Autoimnnunity in Finnish Children At High Risk for Type 1 Diabetes

2014

A Contrast Between Children and Adolescents With Excellent and Poor Control: the T1D Exchange Clinic Registry Experience

2014

9 Beta Polymorphism of the Glucocorticoid Receptor Gene Appears To Have Limited Impact in Patients With Addison's Disease
PLoS One
2014

The Prediction of Type 1 Diabetes By Multiple Autoantibody Levels and Their Incorporation Into An Autoantibody Risk Score in Relatives of Type 1 Diabetic Patients
Diabetes Care
2013

The Autoimmune Disease-Associated Snp Rs917997 of Il18Rap Controls Ifn Gamma Production By Pbmc
Journal of Autoimmunity
2013

Serological Autoantibody Profiling of Type 1 Diabetes By Protein Arrays
Journal of Proteomics
2013

Salivary Cortisol Day Curves in Addison's Disease in Patients On Hydrocortisone Replacement
Hormone and Metabolic Research
2013

Race, Socioeconomic Status, and Treatment Center Are Associated With Insulin Pump Therapy in Youth in the First Year Following Diagnosis of Type 1 Diabetes
Diabetes Technology & Therapeutics
2013

Race and Socioeconomic Status Are Associated With Insulin Pump Therapy in Youth in the First Year Following Diagnosis of Type 1 Diabetes
Diabetes Technology & Therapeutics
2013

Investigation of Glucocorticoid Receptor Polymorphisms in Relation To Metabolic Parameters in Addison's Disease
European Journal of Endocrinology
2013

Interleukin-1 Antagonism in Type 1 Diabetes of Recent Onset: Two Multicentre, Randomised, Double-Blind, Placebo-Controlled Trials
Lancet
2013

Increased Complement Activation in Human Type 1 Diabetes Pancreata
Diabetes Care
2013

Ethnicity Influences the Diagnosis of Primary Adrenal Insufficiency
Clinical Endocrinology
2013

Body Mass Index At the Time of Diagnosis of Autoimmune Type 1 Diabetes in Children
Journal of Pediatrics
2013

Autologous Umbilical Cord Blood Infusion Followed By Oral Docosahexaenoic Acid and Vitamin D Supplementation for C-Peptide Preservation in Children With Type 1 Diabetes
Biology of Blood and Marrow Transplantation
2013

Update On Global Intervention Studies in Type 1 Diabetes
Endocrinology and Metabolism Clinics of North America
2012

Through the Fog: Recent Clinical Trials To Preserve Beta-Cell Function in Type 1 Diabetes
Diabetes
2012

The Use of Leptin as Treatment for Type 1 Diabetes Mellitus: Counterpoint

2012

Performance of Hba(1C) as An Early Diagnostic Indicator of Type 1 Diabetes in Children and Youth
Diabetes Care
2012

Network for Pancreatic Organ Donors With Diabetes (Npod): Developing a Tissue Biobank for Type 1 Diabetes
Diabetes-Metabolism Research and Reviews
2012

Use of a Precious Resource: Parental Decision Making About Using Autologous Umbilical Cord Blood in Studies Involving Young Children With Type 1 Diabetes
Contemporary Clinical Trials
2011

The Pancreas in Human Type 1 Diabetes
Seminars in Immunopathology
2011

Reduced Serum Vitamin D-Binding Protein Levels Are Associated With Type 1 Diabetes
Diabetes
2011

Progressive Erosion of Beta-Cell Function Precedes the Onset of Hyperglycemia in the Nod Mouse Model of Type 1 Diabetes
Diabetes
2011

Long-Term Outcome of Individuals Treated With Oral Insulin Diabetes Prevention Trial-Type 1 (Dpt-1) Oral Insulin Trial
Diabetes Care
2011

It'S Time To Mow the Gras in Type 1 Diabetes
Diabetes
2011

Islet Autoantibody Seroconversion in the Dpt-1 Study Justification for Repeat Screening Throughout Childhood
Diabetes Care
2011

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes
PLoS One
2011

Development of Autoantibodies in the Trialnet Natural History Study
Diabetes Care
2011

Country-Specific Birth Weight and Length in Type 1 Diabetes High-Risk Hla Genotypes in Combination With Prenatal Characteristics
Journal of Perinatology
2011

Co-Stimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: a Randomised, Double-Blind, Placebo-Controlled Trial
Lancet
2011

Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails To Preserve C-Peptide
Diabetes Care
2011

Autoimmune Markers in Diabetes
Clinical Chemistry
2011

Antigen-Based Therapy With Glutamic Acid Decarboxylase (Gad) Vaccine in Patients With Recent-Onset Type 1 Diabetes: a Randomised Double-Blind Trial
Lancet
2011

A Longitudinal Study of Gad65 and Ica512 Autoantibodies During the Progression To Type 1 Diabetes in Diabetes Prevention Trial-Type 1 (Dpt-1) Participants
Diabetes Care
2011

Type I diabetes. Preface.
Endocrinology and Metabolism Clinics of North America
2010

The Pediatric Diabetes Consortium: Improving Care of Children With Type 1 Diabetes Through Collaborative Research
Diabetes Technology & Therapeutics
2010

Lactobacillus Johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in Bb-Dp Rats
PLoS One
2010

Intradermal Alpha 1-Antitrypsin Therapy Avoids Fatal Anaphylaxis, Prevents Type 1 Diabetes and Reverses Hyperglycaemia in the Nod Mouse Model of the Disease
Diabetologia
2010

Harmonization of Glutamic Acid Decarboxylase and Islet Antigen-2 Autoantibody Assays for National Institute of Diabetes and Digestive and Kidney Diseases Consortia
The Journal of Clinical Endocrinology and Metabolism
2010

Failure To Preserve Beta-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New-Onset Type 1 Diabetes
Diabetes Care
2010

Exendin-4 Treatment of Nonobese Diabetic Mice Increases Beta-Cell Proliferation and Fractional Insulin Reactive Area
Journal of Diabetes and Its Complications
2010

Estimating the Cost of Type 1 Diabetes in the Us: a Propensity Score Matching Method
PLoS One
2010

Enhancing the Understanding of Pre-Type 1 Diabetes in the General Population
Diabetes Care
2010

Efforts To Prevent and Halt Autoimmune Beta Cell Destruction
Endocrinology and Metabolism Clinics of North America
2010

Butyrate and Type 1 Diabetes Mellitus: Can We Fix the Intestinal Leak?
Journal of Pediatric Gastroenterology and Nutrition
2010

Autoimmunity Predominates in a Large South African Cohort With Addison's Disease of Mainly European Descent Despite Long-Standing Disease and Is Associated With Hla Dqb{*}0201
Clinical Endocrinology
2010

Vitamin D Levels in Subjets With and Without Type 1 Diabetes Residing in a Solar Rich Environment
Diabetes Care
2009

The road not taken: a path to curing type 1 diabetes?
European Journal of Immunology
2009

Seroconversion in the Dpt-1 Study: Evidence of Triggering of Autoimmune Process At Different Ages

2009

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function
New England Journal of Medicine
2009

Participant and Parent Experiences in the Oral Insulin Study of the Diabetes Prevention Trial for Type 1 Diabetes

2009

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1
Diabetes Care
2009

Pancreatic Adenocarcinoma Patients With Localised Chronic Severe Pancreatitis Show An Increased Number of Single Beta Cells, Without Alterations in Fractional Insulin Area

2009

Network for Pancreatic Organ Donors With Diabetes (Npod): Donor Demographics and Early Progress Report
Hormone Research
2009

Influence of Membrane Cd25 Stability On T Lymphocyte Activity: Implications for Immunoregulation
PLoS One
2009

Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice
Diabetes
2009

Culture-Independent Identification of Gut Bacteria Correlated With the Onset of Diabetes in a Rat Model
The ISME Journal
2009

Challenges in Developing Endpoints for Type 1 Diabetes Intervention Studies
Diabetes-Metabolism Research and Reviews
2009

Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes
Diabetes Care
2009

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus
Jama-Journal of the American Medical Association
2009

What'S in a Name? Thyroid Autoimmunity in Obese Patients With T1D

2008

Type 1 Diabetes Associated With Acquired Generalized Lipodystrophy and Insulin Resistance: the Effect of Long-Term Leptin Therapy
The Journal of Clinical Endocrinology and Metabolism
2008

Neonatal Formula Feeding Leads To Immunological Alterations in An Animal Model of Type 1 Diabetes
Pediatric Research
2008

Murine Antithymocyte Globulin Therapy Alters Disease Progression in Nod Mice By a Time-Dependent Induction of Immunoregulation
Diabetes
2008

Human Alpha 1-Antitrypsin Therapy Induces Fatal Anaphylaxis in Non-Obese Diabetic Mice
Clinical and Experimental Immunology
2008

Exendin-4 Therapy in Nod Mice With New-Onset Diabetes Increases Regulatory T Cell Frequency

2008

Cytokines and Type 1 Diabetes Complications: Casual Or Causal Association?

2008

Cftr Mutations Impart Elevated Immune Reactivity in a Murine Model of Cystic Fibrosis Related Diabetes
Cytokine
2008

Autologous Umbilical Cord Blood Infusion for Type 1 Diabetes
Experimental Hematology
2008

Type 1 diabetes intervention trials 2007: where are we and where are we going?
Current Opinion in Endocrinology & Diabetes
2007

Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.

2007

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
Diabetes
2007

Endocrine complications of childhood cancer therapy: evaluation and management.
Pediatric endocrinology reviews : PER
2007

Adverse impact of temperature and humidity on blood glucose monitoring reliability: a pilot study.
Diabetes Technology & Therapeutics
2007

Managed care organization characteristics and outpatient specialty care use among children with chronic illness.
Pediatrics American Academy of Pediatrics
2005

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
Diabetes
2005

Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.
Journal of Pediatric Gastroenterology and Nutrition
2005

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus--a new surrogate measure of non-progression?

2004

Islet replacement vs. regeneration: hope or hype?

2004

Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: case report.

2004

Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination
Diabetes Care
2003

Prevention strategies for type 1 diabetes mellitus: current status and future directions.
BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals, and Gene Therapy
2003

Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we?
Annals of the New York Academy of Sciences
2002

Type 1 diabetes islet autoantibody markers.
Diabetes Technology & Therapeutics
2002

To screen or not to screen for pre-type 1 diabetes?
Hormone Research
2002

Autoimmune polyglandular syndrome. II: Clinical syndrome and treatment.
Endocrinology and Metabolism Clinics of North America
2002

Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT).
Journal of Pediatric Endocrinology & Metabolism
2001

Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion.
Cell
1991

Research Interests

Up to 3 million Americans are stricken with type 1 diabetes, but the epidemic spans the globe and is rapidly worsening. The frequency of the disease has already soared five-fold in the past 50 years alone, and the costs to human health come into sharp focus. Diabetes is one of six leading causes of death in the United States, and the No. 1 cause of acquired blindness, kidney failure and non-traumatic amputation. It also fuels cardiovascular disease, the nation's No. 1 killer, and accounts for more than $174 billion in health-care expenditures, with type 1 diabetes accounting for a disproportionate share of those costs. Dr Schatz' research has focused on the prediction, natural history, genetics, immunopathogenesis and prevention of Type 1 diabetes, as well as the management of children and adolescents with Type 1 diabetes.

Active Research Studies