OPTIMUS PRIME - Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa
In this study we are evaluating the safety and feasibility of the triple combination (TTFields, MLA, pembrolizumab) in adult patients diagnosed with recurrent or progressive glioblastoma (GBM) WHO Grade IV, IDH wild type or recurrent or progressive…
- Investigator
- Ashley Ghiaseddin
- Status
- Accepting Candidates
- Ages
- 18 Years - 90 Years
- Sexes
- All
EF-41/ KEYNOTE D58
This is a multicenter, two-arm, randomized, double-blind, placebo-controlled study of Optune® (Tumor Treating Fields at 200 kHz) together with maintenance Temozolomide (TMZ) chemotherapy agent and pembrolizumab compared to Optune® together with…
- Investigator
- Ashley Ghiaseddin
- Status
- Accepting Candidates
- Ages
- 18 Years - N/A
- Sexes
- All
ASPIRE: RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)
This is a Phase I study to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in adult patients with recurrent glioblastoma.
- Investigator
- Ashley Ghiaseddin
- Status
- Accepting Candidates
- Ages
- 18 Years - 80 Years
- Sexes
- All