2026
Uncoupling proximal tubule ammoniagenesis from bicarbonate generation by PCK1 deletion
American Journal of Physiology-Renal Physiology
Publisher's siteIrving D Weiner, MD : Research
Nephrologist (Kidney Specialist)
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4.8
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Research at a glance
Top areas of exploration
- Ammonia , 26 publications
- Kidney , 26 publications
- Kidney Tubules, Collecting , 24 publications
- Cation Transport Proteins , 19 publications
Research activity
Focus
Dr. Weiner's research interests focus on the molecular mechanisms and the regulation of acid-base hemostasis. This includes studies on ammonia metabolism, including regulation of production and novel mechanisms of transport by specific proteins. Dr. Weiner's laboratory played a major role in a recognition the Rhesus glycoproteins enable regulated transport of ammonia gas, NH3, which resulted in a paradigm shift in the understanding of ammonia metabolism. The National Institute of Health has funded Dr. Weiner's research program for more than 30 years.
My publications
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88 publications
2026
Effects of proximal tubule NBCe1-A deletion on collecting duct intercalated cell responses to hypokalemia
American Journal of Physiology-Renal Physiology
Publisher's site2025
Incidence of Immune Checkpoint Inhibitor-Associated Renal Tubular Acidosis.
Kidney international reports
PubMed • Publisher's site2025
Lack of a role of NHE4 in renal ammonia metabolism
American Journal of Physiology-Renal Physiology
Publisher's site2024
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase
American Journal of Physiology-Renal Physiology
Publisher's site