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James Wymer, MD, FAAN : Research

Neuromuscular Medicine Specialist

Rated 4.9 out of 5 stars
Photo of James Wymer

Research at a glance

Top areas of exploration

  • Amyotrophic Lateral Sclerosis , 35 publications
  • Deglutition Disorders , 11 publications
  • Deglutition , 10 publications
  • Disease Progression , 9 publications

Research activity

68 publications

2,110 citations

Why is this important?

Active clinical trials

COYA

The ALSTARS trial will be conducted across 20-25 sites in the US and Canada, and will evaluate the safety and efficacy of an investigational treatment called COYA 302 for adults with Amyotrophic Lateral Sclerosis (ALS). COYA 302 is an…

Investigator
James Wymer
Status
Accepting Candidates
Ages
18 Years - 80 Years
Sexes
All
LUMINA

This study is a placebo-controlled Phase I study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide (ASO) AMX0114 in adult participants with amyotrophic lateral sclerosis (ALS).

Investigator
James Wymer
Status
Accepting Candidates
Ages
18 Years - N/A
Sexes
All
ALS Imaging
Investigator
James Wymer
Status
Accepting Candidates

My publications

68 publications

2026

DNL343 and Disease Progression in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

JAMA network open

PubMed • Publisher's site

2026

Prospective Validation of the New PLS Diagnostic Criteria From PLS Natural History Study: EMG and Neurofilament Analyses.

Muscle & nerve

PubMed • Publisher's site

2026

Diagnostic differences between military veterans and non-veterans: data from the United States National ALS Registry.

Amyotrophic lateral sclerosis & frontotemporal degeneration

PubMed • Publisher's site

2026

Author Correction: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation.

Nature neuroscience

PubMed • Publisher's site

2026

Head trauma and environment progression of amyotrophic lateral sclerosis: long-term data from the National ALS Registry.

BMJ neurology open

PubMed • Publisher's site