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Nutrition and the GI environment in the neonate have major effects not only during infancy, but for the entire lifetime of the individual, and this can even span generations due to epigenetic effects. Our lab has several ongoing projects that involve the requirements for certain amino acids such as glutamine and arginine in very low birthweight infants, the effect of various nutrients on subsequent development of Type 1 and Type 2 diabetes, the effect of the intestinal commnensal microflora and probiotics on intestinal development, and the effects of novel nutritional agents on retinal diseases such as retinopathy of prematurity. Our work spans from evaluation of basic mechanisms of nutrients in cell cultures, studies in animal models and translation of these to and from studies in human infants.
IBP-9414 will be evaluated in preterm infants with a birth weight of 500-1500g, compared to placebo with regards to efficacy and safety in the prevention of necrotizing enterocolitis.
243 publications
2024
Frontiers in nutrition
PubMed • Publisher's site2024
Pediatric research
PubMed • Publisher's site2023
American journal of perinatology
PubMed • Publisher's site2023
American journal of perinatology
PubMed • Publisher's site2023
Neonatology
PubMed • Publisher's site